Prof. Xiangfeng Duan and researchers at UCLA have developed a biosensor capable of detecting nitric oxide within in vitro conditions and single cell environments with subnanomolar sensitivity and high selectivity.
UCLA researchers from the departments of chemistry and materials science and engineering have developed a highly sensitive nitric oxide (NO) biosensor by functionalizing graphene field-effect transistors with molecules that can selectively interact with NO. The atomically thin graphene sheet’s high carrier mobility allows highly sensitive detection of electrical readouts from NO signals. This sensor can detect subnanomolar concentrations of NO with high spatiotemporal sensitivity with a detection speed of 1 – 2 seconds.
Invention Information:
Title/Link: Real-Time Electrical Detection of NO in Biological Systems with Subnanomolar Sensitivity
Tech ID: 24020 / UC Case 2013-973-0
Figure from related publication
Schematic illustration of a graphene–hemin conjugate device. (Jiang S., Cheng R., Wang X., Xue T., Liu Y,. Nel A., Huang Y., and Duan X. Real-time electrical detection of nitric oxide in biological systems with sub-nanomolar sensitivity. Nat Commun. 2013;4:2225. doi: 10.1038/ncomms3225.)
