Title: Blue OLED Emitters: Cyclometalated Platinum- and Iridium NHC Complexes Abstract: Organic Light Emitting Diode (OLED) displays stand out as one of the most important developments in display technology. OLEDs offer vibrant, energy-efficient, and flexible displays utilized in a wide array of products, from smartphones to large-scale television screens. Organometallic complexes are used to enhance […]
Title: New Electron-Transfer Concepts in Organic Synthesis Abstract: The Nacsa Group uses electron transfer techniques to address challenges in organic synthesis. Our lab works in two main areas. The first uses electrochemistry to develop new approaches for dehydration reactions, such as the synthesis of amides and esters from carboxylic acids, with an emphasis on catalysis. […]
Title: Anaerobic Heteroatom Transfer Reactions Promoted by Photoexcited 1,3-Dipoles Abstract: Heteroatom units, such as carbonyls, alcohols, and amines, are prevalent motifs in many medicinally important compounds. Methods to incorporate these important functional groups at the expense of hydrocarbons rely on the use of non-commercial heteroatom transfer agents, precious transition metals, and/or costly engineered enzymes. Also, […]
Title: Development of Allosteric Inhibitors of VCP/ p97 to Interrogate Novel Biology and Fuel Cancer Drug Discovery Abstract: Clinical success in targeting the protein degradation pathway using proteasome inhibitors has spurred efforts to evaluate other aspects of this system as approaches to cancer therapy. Among those, the AAA ATPase, p97/ VCP, a master regulator of […]