Professor Heather Maynard and colleagues have developed a novel glycopolymer to be used as the resist in the direct patterning of active biomolecules by electron beam lithography.
Invention: A Novel Glycopolymer for Direct Write of Biomolecules by Lithography
Innovation: Dr. Heather Maynard and colleagues at UCLA have developed a novel glycopolymer to stabilize biomolecules under radiation and vacuum as the resist materials in lithographic processes. The glycopolymer incorporates the disaccharide trehalose, a safe preservative used in the food industry. In the presence of this trehalose-containing glycopolymer, directly-written biomolecules maintain their stability and functional activity while satisfying medical sterility standards. Moreover, multiple proteins can be subsequently written without adversely altering existing patterns or the need to modify differently.
Applications
- Lab-on-a-chip, miniaturized protein arrays for diagnostics, proteomics and biosensors
- High-throughput drug discovery or drug targeting platforms
- Medical implant coatings with patterning to direct tissue regeneration
- Patterning bioactive surfaces to study cell-matrix interactions in cell/tissue analysis
Advantages
- Treatment is the same for every biomolecule whether patterned together or separate, which significantly reduces variations in the standard production of protein arrays.
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Directly patterned biomolecules with this glycopolymer resist satisfy medical sterility and safety standards.
- The dosage used in the electron beam is well above those used to sterilize proteins
Invention information
Title/Link: A Novel Glycopolymer for Direct Write of Biomolecules by Lithography
Tech ID: 24366 / UC Case 2014-842-0
About the Maynard Lab
The Maynard Group performs cutting-edge research on polymer bioconjugates and protein nanoarrays and educates the next generation of researchers and leaders in organic chemistry, polymer science, nanotechnology, and biomedicine. To find out more about Professor Heather Maynard and her research, please visit her group page.
