The structure of telomerase with telomeric DNA from the Feigon lab has been featured as November 2018 “Molecule of the Month” in the RCSB Protein Data Bank.
The structure, from the Feigon group paper titled “Structure of Telomerase with Telomeric DNA” published in the May 17, 2018, issue of the journal Cell, was featured on the RCSB Protein Data Bank (https://www.rcsb.org/), the world-wide repository for biological macromolecule structures determined by NMR, crystal, and cryo electron microscopy. In addition to an illustrated model of the structure (shown below), the RCSB PDB Molecule of the Month provides an introduction to the structure and function of the molecule, a discussion of the relevance of the molecule to human health and welfare, and suggestions for how visitors might view these structures and access further details.
This work was previously highlighted by UCLA Newsroom and the UCLA Institute for Digital Research and Education (IDRE) News.
Professor Juli Feigon, senior author on the study, is a Distinguished Professor of Biochemistry.
This structure of the telomere core includes a reverse transcriptase (TERT) and associated proteins, an RNA template (TER), and a short piece of the telomere DNA.