Wong, Gerard C. L.


Short Biography

Gerard C. L. Wong is a Professor in the Department of Bioengineering, Department of Chemistry, and the California NanoSystems Institute at UCLA. Wong received his BS and PhD at Caltech physics and Berkeley physics respectively. He joined the Materials Science & Engineering Dept and Physics Dept at the University of Illinois at Urbana-Champaign in 2000 and moved to UCLA in 2009.

His research recognition includes: the Beckman Young Investigator Award, Alfred P Sloan Fellowship, and Sackler Distinguished Speaker. He is a Fellow of the American Physical Society (2011), a Fellow of the American Academy of Microbiology (2016), and a Fellow of the American Institute for Medical and Biological Engineering (2018). His current research interests include bacterial biofilm communities, innate immunity, and antibiotic design.

Research Interests

Bioengineering Research by Dr. Gerard WongBioengineering

Dr. Wong is interested in a multi-disciplinary approach to solving problems in biology and biomedicine., combining physics, chemistry, biology, and engineering.  The group is inherently interdisciplinary; our collaborations include physicists, chemists, material scientists, biologists, medical doctors, and bioengineers.




  • Innate immunity (control of immune system, autoimmune diseases, cancer immunotherapy)
  • Antimicrobials and antibiotic-resistant pathogens
  • Bacterial communities (Ex: signaling, motility, social organization in biofilms)
  • Cystic Fibrosis
  • Apoptosis proteins and cancer therapeutics
  • Disinfection and water purification
  • Self-assembly in biology and biotechnology (Ex: drug and gene delivery)
  • Physical chemistry of solvation (Ex: femtosecond hydration dynamics of ions and surfaces)
  • Soft condensed matter physics (Ex: polymers, polyelectrolytes, liquid crystals, colloids, nanoparticles)
  • Biophysics (Ex: DNA, membranes, proteins)

Honors & Awards

  • Fellow of the American Institute for Medical and Biological Engineering (2018) (AIMBE College of Fellows)
  • Fellow of the American Academy of Microbiology (2016)
  • Fellow of the American Physical Society (2011)
  • Racheff Faculty Scholar Award, 2008
  • Xerox Foundation Award for Senior Faculty Research, 2008
  • Prostate Cancer Foundation Competitive Award, 2007
  • Selection to the Frontiers of Engineering Symposium sponsored by the National Academy of Engineering, 2006
  • Xerox Foundation Award for Junior Faculty Research, 2005
  • Alfred P. Sloan Foundation Fellowship, 2004
  • Burnett Teaching Award, 2003
  • Beckman Young Investigator Award, 2001
  • Fellow of the American Institute for Medical and Biological Engineering (2018) (AIMBE College of Fellows)
  • Apker Prize, American Physical Society (1987) (1st Prize, U.S. National Undergraduate Physics Thesis Competition)

Representative Publications

[ Selected Recent Publications ]

  • Lauren K. Nicastro, Jaime De Anda, Neha Jain, Kaitlyn C. M. Grando, Amanda L. Miller, Shingo Bessho, Stefania Gallucci, Gerard C. L. Wong, Çagla Tükel, “Assembly of ordered DNA-curli fibril complexes during Salmonella biofilm formation correlates with strengths of the type I interferon and autoimmune responses”, Accepted in PLoS Pathogens, (2022)
  • Shanice S. Webster, Gerard C. L. Wong, and George A. O’Toole, “The Power of Touch: Type 4 Pili, the von Willebrand A domain and Surface Sensing by Pseudomonas aeruginosa“, J. Bacteriol.204(6)e00084-22. (2022)
  • Kaitlyn Grando, Lauren K. Nicastro, Sarah Tursi, Jaime De AndaErnest Y. LeeGerard C. L. Wong, Çagla Tükel, “Phenol-soluble modulins from Staphylococcus aureus biofilms form complexes with DNA to drive autoimmunity”, Frontiers in Cellular and Infection Microbiology12:884065. (2022)
  • Kimberley A. Lewis, Danielle M. Vermilyea, Shanice S. Webster, Christopher J. Geiger, Jaime de AndaGerard C. L. Wong, George A. O’Toole, Deborah A. Hogan, “Nonmotile Subpopulations of Pseudomonas aeruginosa Repress Flagellar Motility in Motile Cells through a Type IV Pilus- and Pel-Dependent Mechanism”, J. Bacteriol.205(5):e00528-21. (2022)
  • Wujing Xian, Matthew R. Hennefarth, Michelle W. Lee, Tran Do, Ernest Y. Lee, Anastassia N. Alexandrova, Gerard C.L. Wong, “Histidine-Mediated Ion Specific Effects Enable Salt Tolerance of a Pore-Forming Marine Antimicrobial Peptide”, Angew. Chem. Int. Ed.,                   61(25): e202108501. (2022).
  • Shanice S. Webster, Marion Mathelié-Guinlet, Andreia F. Verissimo, Daniel Schultz, Albertus Viljoen, Calvin K. LeeWilliam C. SchmidtGerard C. L. Wong, Yves F. Dufrene, George A. O’Toole, “Force-induced changes of PilY1 drive surface sensing by Pseudomonas aeruginosa“, mBio13 (1):e03754-21. (2021).
  • Calvin K. LeeWilliam C. Schmidt, Shanice S. Webster, Jonathan W. Chen, George A. O’Toole, Gerard C. L. Wong, “Broadcasting of amplitude and frequency modulated c-di-GMP signals facilitates cooperative surface commitment in bacterial lineages”, Proc. Nat. Acad. Sci. USA119 (4) e2112226119 (2022)
  • Bocheng Cao, Zipeng Zhao, Lele Peng, Hui-Ying Shiu, Mengning Ding, Frank Song, Xun Guan, Calvin K. Lee, Jin Huang, Dan Zhu, Xiaoyang Fu, Paul S. Weiss, Gerard C. L. Wong, Kenneth Nealson, Chong Liu, Xiangfeng Duan, Yu Huang, “Silver nanoparticles boost charge-extraction efficiency in Shewanella microbial fuel cells”, Science373 (6561):1336-1340 (2021).
  • Michael K. Thorsen, Alex Lai, Michelle W. Lee, David P. Hoogerheide, Gerard C. L. Wong, Jack H. Freed, and Ekaterina E. Heldwein, “Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering”, mBio12 (4):e0154821. (2021).
  • Michelle W. LeeElizabeth W. C. Luo, Carlos Silvestre-Roig, Yashes Srinivasan, Kiyotaka Akabori, Patricia Lemnitzer, Nathan W. SchmidtGhee Hwee Lai, Christian D. Santangelo, Oliver Soehnlein, Gerard C. L. Wong, “Apolipoprotein mimetic peptide inhibits neutrophil-driven inflammatory damage via membrane remodeling and suppression of cell lysis”, ACS Nano118 PMID: 34586780 (2021)
  • Shanice S. Webster, Calvin K. LeeWilliam C. SchmidtGerard C. L. Wong, George A. O’Toole, “Interaction between the type 4 pili machinery and a diguanylate cyclase fine-tune c-di-GMP levels during early biofilm formation”, Proc. Nat. Acad. Sci. USA118 (26) e2105566118 (2021)
  • Nikhil N. Kulkarni, Alan M. O’Neill, Tatsuya Dokoshi, Elizabeth W. C. LuoGerard C. L. Wong, Rich Gallo, “Sequence determinants in the cathelicidin LL37 that promote inflammation via presentation of RNA to scavenger receptors”, J. Biol. Chem.297(1):100828 (2021)
  • Gerard C. L. Wong, Jyot D. Antani, Pushkar Lele, Jing Chen, Beiyan Nan, Marco Julian Kühn, Alexandre Persat, Jean-Louis Bru, Nina Molin Høyland-Kroghsbo, Albert Siryaporn, Jacinta Conrad, Francesco Carrara, Yutaka Yawata, Roman Stocker, Yves Brun, Greg Whitfield, Calvin LeeJaime de AndaWilliam C Schmidt, Ramin Golestanian, George A. O’Toole, Kyle Floyd, Fitnat Yildiz, Shuai Yang, Fan Jin, Masanori Toyofuku, Leo Eberl, Nomura Nobuhiko, Lori Zacharoff, Mohamed Y El-Naggar, Sibel Ebru Yalcin, Nikhil Malvankar, Mauricio D. Rojas-Andrade, Allon Hochbaum, Jing Yan, Howard A. Stone, Ned S. Wingreen, Bonnie Bassler, Yilin Wu, Haoran Xu, Knut Drescher, and Jörn Dunkel, “Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation”, Physical Biology18 051501 (2021) PMID: 33462162
  • Ernest Y. Lee, Liana C. Chan, Huiyuan Wang, Juelline Lieng, Mandy Hung, Yashes Srinivasan, Jennifer Wang, James Waschek, Andrew L. Ferguson, Kuo-Fen Lee, Nannette Y. Yount, Michael R. Yeaman, Gerard C.L. Wong, “PACAP is a pathogen-inducible resident antimicrobial neuropeptide affording rapid and contextual molecular host defense of the brain”, PNAS 118 (1), e1917623117 (2021)
  • Xinhua Chen*, Xiaotong Yang*, Jaime de Anda*, Jun Huang, Dan Li, Hua Xu, Kelsey S. Shields, Mária Džunková, Joshua Hansen, Ishan J. Patel, Eric U. Yee, Douglas T. Golenbock, Marianne A. Grant, Gerard C. L. Wong#, and Ciarán P. Kelly (*Co-first authors), “Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll Like Receptor 9 Signaling”, Gastroenterology , 156 (6), 2181-2192 (2020)
  • Nannette Y. Yount, David C. Weaver, Jaime de Anda, Ernest Y. Lee, Michelle W. LeeGerard C.L. Wong, Michael R. Yeaman, “Discovery of Novel Type II Bacteriocins Using a New High-Dimensional Bioinformatic Algorithm”, Frontiers in Immunology11 1873 (2020)
  • Ernest Y. Lee, Yashes Srinivasan, Jaime de Anda, Lauren K. Nicastro, Çagla Tükel, Gerard C.L. Wong, “Functional reciprocity of amyloids and antimicrobial peptides: Rethinking the role of supramolecular assembly in host defense, immune activation, and inflammation”, Frontiers in Immunology11 1629 (2020)
  • Thomas D. Young, Walter T. Liau, Calvin K. Lee, Michael Mellody, Gerard C. L. Wong, Andrea M. Kasko, and Paul S. Weiss, “Selective Promotion of Adhesion of Shewanella oneidensis on Mannose-Decorated Glycopolymer Surfaces”, ACS Appl. Mater. Interfaces 12 (32), 35767-35781 (2020)
  • Alexander Klimovich , Stefania Giacomello , Åsa Björklund , Louis Faure , Marketa Kaucka , Christoph Giez , Andrea P. Murillo-Rincon , Ann-Sophie Matt , Doris Willoweit-Ohl , Gabriele Crupi , Jaime de AndaGerard C.L. Wong , Mauro D’Amato , Igor Adameyko , Thomas C.G. Bosch, “Prototypical pacemaker neurons interact with the resident microbiota”, PNAS117 (30) 17854-17863 (2020)
  • Jie He, Monica A. Thomas, Jaime de AndaMichelle W. Lee, Emma Van Why, Pippa Simpson, Gerard C. L. Wong, Mitchell H. Grayson, Brian F. Volkman, Anna R. Huppler, “Chemokine CCL28 Is a Potent Therapeutic Agent for Oropharyngeal Candidiasis”, Antimicrob Agents Chemother64 (8) e00210-20 (2020)
  • Michelle W. LeeJaime de Anda, Carsten Kroll, Christoph Bieniossek, Kenneth Bradley, Kurt E. Amrein, Gerard C. L. Wong, “How do cyclic antibiotics with activity against Gram-negative bacteria permeate membranes? A machine learning informed experimental study”, BBA Biomembranes 1862 (8), 183302 (2020)
  • Acacia Dishman*, Michelle W. Lee*Jaime de AndaErnest Y. Lee , Jie He, Anna Huppler, Gerard Wong , Brian Volkman (*Co-first authors), “Switchable membrane remodeling and antifungal defense by metamorphic chemokine XCL1”, ACS Infectious Diseases 6 (5), 1204-1213 (2020)
  • Kyle A. Floyd, Calvin K. LeeWujing Xian, Mahmoud Nametalla, Aneesa Valentine, Benjamin Crair, Shiwei Zhu, Hannah Q. Hughes, Jennifer L. Chlebek, Daniel C. Wu, Jin Hwan Park, Ali M. FarhatCharles J. Lomba, Courtney K. Ellison, Yves V. Brun, Javier Campos-Gomez, Ankur B. Dalia6, Jun Liu, Nicolas Biais, Gerard C. L. Wong†, and Fitnat H. Yildiz† (†Co-corresponding authors), “C-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae”, Nature Commun 11, 1549 (2020)
  • Daniel C. Wu, David Zamorano-Sánchez, Fernando A. Pagliai, Jin Hwan Park, Kyle A. Floyd, Calvin K. Lee, Giordan Kitts, Christopher B. Rose, Eric M. BilottaGerard C. L. Wong, and Fitnat H. Yildiz, “Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation”, PLoS Genetics 16 (3), e1008703 (2020)
  • Calvin Kai-man Lee*, Jérémy Vachier*, Jaime de Anda, Kun Zhao, Amy E. Baker, Rachel R. Bennett, Catherine R. Armbruster, Kimberley A. Lewis, Rebecca L. Tarnopol, Charles J. Lomba, Deborah A. Hogan, Matthew R. Parsek, George A. O’Toole, Ramin Golestanian†, Gerard C. L. Wong† (*Equal contribution †Co-corresponding authors), “Social Cooperativity of Bacteria during Reversible Surface Attachment in Young Biofilms: a Quantitative Comparison of Pseudomonas aeruginosa PA14 and PAO1″, mBio11 (1), e02644-19 (2020)
  • Catherine R. Armbruster*, Calvin K. Lee*, Jessica Parker-Gilham, Jaime de Anda, Aiguo Xia, Boo Shan Tseng, Lucas R. Hoffman, Fan Jin, Caroline Harwood, Gerard C. L. Wong, Matthew R Parsek (*Equal contribution), “Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations”, eLife, (2019)
  • Brittany J. Belin, Elise T. Tookmanian, Jaime de AndaGerard C.L. Wong, and Dianne Newman, Extended hopanoid loss reduces bacterial motility and surface attachment, and leads to heterogeneity in root nodule growth kinetics in a Bradyrhizobium-Aeschynomene symbiosis”, Molecular Plant-Microbe Interactions32:10, 1415-1428 (2019)
  • Carlos Silvestre-Roig*, Quinte Braster*, Kanin Wichapong, Ernest Y. Lee, Jean Marie Teulon, Nihel Berrebeh, Janine Winter, Alexander Froese, José M. Adrover, Almudena Ortega-Gómez, Julian Marschner, Nicole Paulin, Patricia Lemnitzer, Ariane Schmuski, Carla Winter, Tom Schoufour, Helene Hartwig, Silvia González Ramos, Frits Kamp, Remco T. A. Megens, Christian Weber, Esther Lutgens, Mat Daemen, Hans-Joachim Anders, Viacheslav O. Nikolaev, Andrés Hidalgo, Jean-Luc Pellequer, Gerry Nicolaes, Gerard C. L. Wong, and Oliver Soehnlein
    (*Equal contribution), “Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death”, Nature569 (7755), 236-240 (2019)
  • David Zamorano-Sánchez*, Wujing Xian*, Calvin Lee, Mauro Salinas, Wiriya Thongsomboon, Lynette Cegelski, Gerard Wong, and Fitnat Yildiz (*Equal Contribution), “Functional specialization in Vibrio cholerae diguanylate cyclases: distinct modes of motility suppression and c-di-GMP production”, mBio10 (2), e00670-19 (2019)
  • Roberto Lande†, Ernest Y. Lee, Raffaella Palazzo, Immacolata Pietraforte, Yves Mattenberger, Francesca Spadaro, Katia Stefanantoni, Nicoletta Iannace, Aleksandra Maria Dufour, Mario Falchi, Manuela Bianco, Montserrat Alvarez, Valeria Riccieri, Marie-Elise Truchetet, Gerard C.L. Wong†, Carlo Chizzolini†, Loredana Frasca† (†Co-corresponding authors), “CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis”, Nature Communications10 (1), 1731 (2019)
  • Nannette Y. Yount , David C. Weaver, Ernest Y. Lee, Michelle W. Lee, Huiyuan Wang, Liana C. Chan, Gerard C.L. Wong, Michael R. Yeaman, “A Unifying Structural Signature of Eukaryotic α-helical Host Defense Peptides”, PNAS, 116 (14), 6944-6953 (2019)
  • Ernest Y. Lee*, Changsheng Zhang*, Jeremy Di Domizio, Fan Jin, Will Connell, Mandy Hung, Nicolas Malkoff, Veronica Veksler, Michel Gilliet, Pengyu Ren†, Gerard C. L. Wong†, (*Equal contribution †Co-corresponding authors), “Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9”, Nature Communications, 10 (1), 1012 (2019)
  • Ernest Y. Lee, Michelle W. Lee, Gerard C.L. Wong, “Modulation of Toll-like receptor signaling by antimicrobial peptides”, Seminars in Cell & Developmental Biology, 38, 204-213 (2018)
  • Michelle W. Lee, Ernest Y. Lee, Andrew L. Ferguson, and Gerard C. L. Wong, “Machine Learning Antimicrobial Peptide Sequences: Some Surprising Variations on the Theme of Amphiphilic Assembly”, Current Opinion in Colloid and Interface Science, 38, 204-213 (2018)
  • Michelle W. Lee, Ernest Y. Lee, Gerard C.L. Wong, “What can pleiotropic proteins in innate immunity teach us about bioconjugation and molecular design?”, Bioconjugate Chemistry, 29 (7), 2127-2139 (2018)
  • Calvin K. Lee, Jaime De Anda, Amy E. Baker, Rachel R. Bennett, Yun Luo, Joshua A. Keefe, Joshua S. Helali, Jie Ma, Kun Zhao, Ramin Golestanian, George A. O’Toole, and Gerard C. L. Wong, “Cyclic AMP Mediates Memory and Behavior Adaptation during Surface Sensing and Early Pseudomonas aeruginosa Biofilm Formation”, Proc. Nat. Acad. Sci. USA (2018), in press. https://doi.org/10.1073/pnas.1720071115
  • Michelle W. Lee, Ernest Y. Lee, Ghee Hwee Lai, Nolan W. Kennedy, Ammon E. Posey, Wujing Xian, Andrew L. Ferguson, R. Blake Hill, Gerard C. L. Wong, “Molecular Dnm1 synergistically induces membrane curvature to facilitate mitochondrial fission”, ACS Central Science 3, 1156-1167 (2017), cover article. PMID: 29202017. PMCID: PMC5704292.
  • Jaime De Anda, Ernest Y. Lee, Calvin K. Lee, Rachel R. Bennett, Xiang Ji, Soheil Soltani, Mark C. Harrison, Amy E. Baker, Yun Luo, Tom Chou, George A. O’Toole, Andrea M. Armani, Ramin Golestanian, Gerard C. L. Wong, “High-speed “4D” computational microscopy of bacterial surface motility”, ACS Nano 11, 9340-9351 (2017). PMID: 28836761.
  • Ernest Y. Lee, Toshiya Takahashi, Tine Curk, Jure Dobnikar, Richard L. Gallo, Gerard C. L. Wong, “Crystallinity of dsRNA-AMP complexes modulates TLR3-mediated inflammation”, ACS Nano 11, 12145-12155 (2017). PMID: 29016111.
  • Sarah A. Tursi, Ernest Y. Lee, Nicole J. Medeiros, Michael H. Lee, Bettina Butter, Stefania Gallucci, Ronald P. Wilson, Gerard C. L. Wong, Cagla Tukel, “Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9”, PLoS Pathogens, 13 (4), e1006315 (2017). PMID: 28410407. PMCID: PMC5406031.
  • Michelle W. Lee, Ming Han, Guilherme Bossa, Carly Snell, Ziyuan Song, Haoyu Tang, Lichen Yin, Jianjun Cheng, Sylvio May, Erik Luijten, G. C. L. Wong, “Interactions between membranes and ‘metaphilic’ polypeptide architectures with diverse sidechain populations”, ACS Nano 11 (3), 2858-2871 (2017). PMID: 28212487.
  • Anatolij Gelimson, Kun Zhao, Calvin K. Lee, W. Till Kranz, G. C. L. Wong, Ramin Golestanian, “Multicellular self-organization of P. aeruginosa due to interactions with secreted trails”, Phys. Rev. Lett., 117, 178102 (2016). PMID: 27824438.
  • Mengning Ding, Hui-Ying Shiu, Shiue-Lin Li, Calvin K. Lee, Gongming Wang, Hao Wu, Nathan O. Weiss, Thomas D. Young, Paul S. Weiss, G. C. L. Wong, Kenneth H. Nealson, Yu Huang, and Xiangfeng Duan, “Nanoelectronic Investigation Reveals the Electrochemical Basis of Electrical Conductivity in Shewanella and Geobacter”, ACS Nano 10 9919-9926 (2016). PMID: 27787972.
  • Calvin K. Lee, Alexander J. Kim, Giancarlo S. Santos, Peter Y. Lai, Stella Y. Lee, David F. Qiao, Jaime De Anda, Thomas D. Young, Yujie Chen, Annette R. Rowe, Kenneth H. Nealson, Paul S. Weiss, and G. C. L. Wong, “Evolution of Cell Size Homeostasis and Growth Rate Diversity during Initial Surface Colonization of Shewanella oneidensis”, ACS Nano 10 9183-9192 (2016). (See Perspectives article in same issue) PMID: 27571459.
  • Ernest Y. Lee, Benjamin M. Fulan, G.C.L. Wong*, A. Ferguson*, “Mapping membrane activity in undiscovered peptide sequence space using machine learning”, Proc. Nat. Acad. Sci. USA, 113, 13588-13593 (2016) (*co-corresponding authors). PMID: 27849600. PMCID: PMC5137689.
  • W. T. Kranz, A. Gelimson, K. Zhao, C. Lee, G. C. L. Wong, R. Golestanian, “Effective dynamics of microorganisms that interact with their own trails”, Phys. Rev. Lett., 117, 038101 (2016). PMID: 27472143.
  • G. A. O’Toole, G. C. L. Wong, “Sensational biofilms: surface sensing in bacteria”, Current Opinion in Microbiology, 30, 139-146 (2016). PMID: 26968016. PMCID: PMC4843124.
  • Julie S. Biteen, Paul C. Blainey, Zoe G. Cardon, Miyoung Chun, George Church, Pieter C. Dorrestein, Scott E. Fraser, Jack Gilbert, Janet K. Jansson, Rob Knight, Jeffery F. Miller, Aydogan Ozcan, Kimberly A. Prather, Sharif Taha, Ger van den Engh, Stephen Quake, Edward G. Ruby, Pamela Silver, Paul S. Weiss, G. C. L. Wong, Aaron T. Wright, X. Sunney Xie, Thomas D. Young, “Tools for the microbiome: Nano and beyond”, ACS Nano, 10, 6-37, featured on cover (2016). PMID: 26695070.
  • M. Xiong, M. W. Lee, Z. Song, C. Yao, G. C. L. Wong, J. J. Cheng, “Helical antimicrobial polypeptides with radial amphiphilicity”, Proc. Nat. Acad. Sci. USA, 112 13155-13160 (2015). PMID: 26460016. PMCID: PMC4629321.
  • H. Yao, M. W. Lee, A. J. Waring, G. C. L. Wong, M. Hong, “Viral fusion protein transmembrane domain adopts beta-strand structure to facilitate membrane topological changes for virus-cell fusion”, Proc. Nat. Acad. Sci. USA, 112 10926-10931 (2015). PMID: 26283363. PMCID: PMC4568205.
  • C. J. Jones, A. S. Utada, K. Davis, W. Thongsomboon, D. Zamorano-Sánchez, V. Banakar, L. Cegelski, G. C. L. Wong, F. Yildiz, “c-di-GMP regulates motile to sessile transition by modulating MshA pili biogenesis and near-surface motility behavior in Vibrio cholera”, PLOS Pathogens 11, e1005068 (2015). PMID: 26505896. PMCID: PMC4624765.
  • N. W. Schmidt, F. Jin, R. Lande, T. Curk, W. Xian, C. Lee, L. Frasca, J. Dobnikar, D. Frenkel, M. Gilliet, G. C. L. Wong, “Liquid crystalline ordering of antimicrobial peptide-DNA complexes controls TLR9 activation”, Nature Materials 14, 696-700 (2015). PMID: 26053762.
  • J. R. Kramer, N. W. Schmidt, K. M. Mayle, D. T. Kamei, G. C. L. Wong, and Timothy J. Deming, ‘Reinventing cell penetrating peptides using glycosylated methionine sulfonium ion sequences”, ACS Central Science 1, 83-88 (2015). PMID: 27162954.
  • J. K. Teschler, D. Zamorano-Sánchez, A. S. Utada, C. J. A. Warner, G. C. L. Wong, R. G. Linington, F. H. Yildiz, “Living in the matrix: a guide to Vibrio cholera biofilms” Nature Reviews Microbiology 13, 255-268 (2015). PMID: 25895940. PMCID: PMC4437738.
  • Yun Luo, Kun Zhao, Amy E. Baker, Matthew C. Wolfgang, G. C. L. Wong, and George A. O’Toole, “Surface Sensing? A hierarchical cascade of second messengers regulates Pseudomonas aeruginosa surface behaviors”, mBio 6, e02456-14 (2015). PMID: 25626906. PMCID: PMC4324313.
  • N. W. Schmidt, S. Deshayes, S. Hawker, A. Blacker, A. M. Kasko, G. C. L. Wong, “Engineering Persister-Specific Antibiotics with Synergistic Antimicrobial Functions”, ACS Nano, 8, 8786-8793 (2014), featured in ACS Editors’ Choice. PMID: 25130648. PMCID: PMC4173747
  • A. S. Utada, R. R. Bennett, J. C. N. Fong, M. L. Gibiansky, F. H. Yildiz, R. Golestanian, and G. C. L. Wong, “Vibrio cholera use pili and flagella synergistically to effect motility switching and conditional surface attachment”, Nature Comm., 5, 4913 (2014). PMID: 25234699. PMCID: PMC4420032.
  • N. W. Schmidt, A. Mishra, J. Wang, W. F. DeGrado, G. C. L. Wong, “Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission”, J. Am. Chem. Soc., 135, 13710-13719 (2013). PMID: 23962302. PMCID: PMC4000230.
  • K. Zhao, B. S. Tseng, B. Beckerman, F. Jin, M. L. Gibiansky, J. J. Harrison, E. Luijten, M. R. Parsek and G. C. L. Wong, “Psl trails guide exploration and microcolony formation in early P. aeruginosa biofilms”, Nature 497, 388-392 (2013). PMID: 23657259. PMCID: PMC4109411
  • M. L. Gibiansky, W. Hu, K. Dahmen, W. Shi, and G. C. L. Wong, “Earthquake-like dynamics in Myxococcus xanthus social motility”, Proc. Nat. Acad. Sci. USA, 110 2330-2335 (2013). PMID: 23341622. PMCID: PMC3568354.