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Special Organic Seminar: “Challenges in Regiocontrol of Benzyne Reactions”

Organic Colloquium, Seminars

Where Cram Conference Room – 3440 Molecular Sciences Bldg
Speaker Professor Takashi Ikawa


Special Organic Seminar

“Challenges in Regiocontrol of Benzyne Reactions”

Abstract.  Benzyne (= ortho-Benzyne) is one of the most important reactive intermediates bearing a triple bond in a benzene ring. Numerous benzyne reactions have been developed during the last three decades while a mild benzyne generation using a fluoride ion has been recognized as an extraordinary useful method. However, it is also true that chemists have suffered from low regioselectivities of unsymmetrically substituted benzynes. Therefore, specific directing groups that have a strong effect on controlling the orientation of the cycloaddition reactions and also can be converted into any other substituents after the cycloaddition have been long desired. In this seminar, I would like to present some of our recent work on regioselectivity control of benzyne reactions using substituent effect of silyl and boryl groups. The origin of regiochemistry would be theoretically explained by DFT (density functional theory) calculation at the B3LYP/6-31G(d) level and NBO (Natural Bond Orbital) analysis.

Professor Takashi Ikawa

Organic Colloquium, Seminars

Graduate School of Pharmaceutical Sciences

Osaka University