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Small molecule inhibitors of 15-prostaglandin dehydrogenase promote tissue repair and regeneration

Organic Colloquium, Seminars

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Speaker Prof. Joseph Ready
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Abstract: Prostaglandin E2 promotes tissue repair and regeneration in multiple tissues. Small molecule inhibitors of the PGE2-degrading enzyme, 15-prostaglandin dehydrogenase, could elevate PGE2 levels in vivo with applications in multiple disease contexts. We have discovered two chemical series of enzyme inhibitors. Medicinal chemistry efforts have led to sub-nM inhibitors with excellent bioavailability and physicochemical properties. Lead compounds demonstrate activity in mouse models of inflammatory bowel disease, recovery from bone marrow transplantation, and neurodegeneration.

Prof. Joseph Ready

Organic Colloquium, Seminars

Department of Biochemistry

UT Southwestern Medical Center

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