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Jeffrey I. Zink Inorganic Chemistry Seminar Series: Tatiana Bronich

Inorganic, Seminars

March 1, 2023 4:00 pm - 5:30 pm
Mani L. Bhaumik Centennial Collaboratory
607 Charles E. Young Dr., East
Los Angeles, CA 90095 United States


Flyer: Prof. Tatiana Bronich Flyer

Meet the Speaker: 11 a.m., YH 3096

Title: Amphiphilic copolymers mediated therapeutics in cancer

Abstract: Amphiphilic block copolymers, in particular self-assembled block copolymer micelles, have been utilized in pharmaceutics for development of novel therapeutic and diagnostic modalities. Advantages of the polymeric micelles include their small size, long circulation in bloodstream, ability to circumvent renal excretion and extravasation at sites of enhanced vascular permeability. They can be designed to facilitate the incorporation of a variety of compounds or even particles through a combination of electrostatic, hydrophobic, and hydrogen bonding interactions. Combining drugs cargos with synergistic activities in a single polymer micelle emerged as an attractive strategy for the development of cancer treatment modalities with enhanced therapeutic efficacy and reduced adverse side effects. We have adopted a polypeptide-based polymer platform as the biodegradable construction material for design of micellar nanocarriers for combination therapy in cancer.