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Physical Chemistry Seminar 228: Lu Wei

Physical Chemistry Seminar

November 20, 2023 4:00 pm - 5:00 pm
Mani L. Bhaumik Centennial Collaboratory
607 Charles E. Young Dr., East
Los Angeles, CA 90095 United States
Speaker Professor Lu Wei


Wei Flyer

Title: Functional Bond-Selective Microscopy for Subcellular Bioanalysis

Abstract: Innovations in optical spectroscopy and microscopy have revolutionized our understanding in live biological systems at the sub-cellular levels. In this talk, I will present our recent advances in developing and applying functional bond-selective spectro-microscopy for investigating subcellular biological activities with rich chemical information. In the first part of my talk, I will present the novel coupling of the stimulated Raman scattering (SRS) imaging, a nonlinear Raman imaging modality, with the newly developed chemical strategies for Raman-guided intracellular metabolic mapping; quantitative subcellular analysis of cytoplasmic aggregates; photo-activatable and photo-switchable SRS spectral-imaging; intracellular sensing through alkyne-HDX; and toward super-resolution chemical imaging. In the second part of my talk, I will present a new mid-infrared near-infrared two-photon imaging technique for bond-selective fluorescence imaging with single-molecule sensitivity.

Professor Lu Wei

Physical Chemistry Seminar

Division of Chemistry and Chemical Engineering

California Institute of Technology