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Houk-Jung Organic Colloquium 247: Dr. Liela Romero

Organic Colloquium

October 26, 2023 4:00 pm - 5:00 pm
Mani L. Bhaumik Centennial Collaboratory
607 Charles E. Young Dr., East
Los Angeles, CA 90095 United States
Speaker Dr. Liela Romero


Romero Flyer

Title: Highly Selective Catalytic Platforms for Reduction and Interhalogenation Chemistry: Our Early Explorations in ZrH and Lewis Base Catalysis

Abstract: Research in the Romero group is centered on the development and mechanistic study of novel catalytic reactions, with applications in natural product synthesis and drug discovery. To this end, we are exploring new avenues for the catalytic halo- and hydrofunctionalization of simple π-systems. The first research program regards our efforts to develop a unified strategy for the interhalogenation of alkenes and alkynes via Lewis base activation of sulfinyl halides. This approach furnishes vicinal dihalides with pronounced chemo-, regio-, and stereocontrol. Notably, when 1–3 mol% of a chiral Lewis basic catalyst is employed, a novel enantioselective bromochlorination of chalcones is realized. The second part of this seminar will focus on the development of a general platform for zirconocene hydride catalysis utilizing hydrosilanes as mild reductants. This catalytic system enables a variety of chemoselective and redox-economic functional group interconversions, including the catalytic semi-reductive diversification of amides and esters, as well as the hydrofunctionalization of alkynes.

Dr. Liela Romero

Organic Colloquium

Department of Chemistry and Biochemistry

Baylor University