Title: Development of Allosteric Inhibitors of VCP/ p97 to Interrogate Novel Biology and Fuel Cancer Drug Discovery Abstract: Clinical success in targeting the protein degradation pathway using proteasome inhibitors has spurred efforts to evaluate other aspects of this system as approaches to cancer therapy. Among those, the AAA ATPase, p97/ VCP, a master regulator of […]

Title: Catalytic strategies for the selective construction of sp3-rich organic scaffolds Abstract: The topological complexity of sp3-rich scaffolds imparts specific beneficial properties into organic small molecules and enables refined tuning of a molecule’s properties. However, this complexity amplifies both reactivity and selectivity challenges, making the development of versatile methods to construct and diversify these structures […]