Abstract: The NIH Molecular Libraries Program was founded to translate the discoveries of the Human Genome Project into therapeutics through a network of high-throughput screening (HTS) centers. A decade of discovery produced hundreds of probes—highly selective small molecules that modulate cellular function—but centralized HTS bears the same cost and infrastructure burdens of millennial DNA sequencing […]

“Van der Waals Integration beyond 2D Heterostructures” Abstract: The integration of dissimilar materials to form heterostructures with designable electronic interfaces is central in modern electronic devices and has thus been a long pursuit in material science. The traditional integration methods such as metal evaporation, atomic layer deposition (ALD) and epitaxial growth typically rely on strong […]

Abstract: The introduction of unnatural functionality in biological systems coupled with detection using bioorthogonal chemical reactions revolutionized the field of chemical biology by enabling the investigation biological processes in live cells and simple organisms. However the translation to complex organisms has led to less than optimal results with high background noise due to cross reactivity […]

Secondary Coordination Effects in Artificial Biotin-Streptavidin Metalloenzymes Designing artificial metalloenzymes is of interest because they combine the catalytic activity of possibly non-physiological but highly catalytically potent metals and the selectivity and mild operational conditions enabled by the protein. This talk will focus on joint theory-experiment efforts to design Rh and Ir artificial metalloenzymes, catalyzing the […]

The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday, May 11th, 2021 at 1:00 PM. We are pleased to invite all students, postdocs, faculty, and staff.

Abstract: RNA transcribed from the genome in the nucleus bears little resemblance to the RNA polymer it will ultimately become in the cytoplasm where it is translated into protein. Well-known processes such as capping, splicing and polyadenylation, as well as the recently discovered and ever-expanding list of diverse chemical modifications and editing, significantly alter the […]

“Molecular Dynamics and Glass Formation of Nanoscopically Confined Polymer” Many technological advances are driven by the ongoing emergence of nanostructured polymers as the critical component to enable innovation. Yet, from a materials design perspective, we cannot presume that the bulk properties of polymers define their behavior when physically confined to nanoscale dimensions. This is, in […]

Exploration of Chemical Functionality of Self-Assembled Carborane Derivatives

The Center for Integrated Catalysis is hosting a new seminar series called the "Careers in Green Chemistry." With these webinars, we aim to bring speakers from a wide variety of careers, linked through green chemistry, to come talk about their current job as well as the career path that led them to that position. We are pleased […]

Abstract: As more attention is focused on biomaterials for medical applications, synthetic polypeptides offer a useful approach towards designing novel biomimetic materials. Polypeptides are inherently biodegradable and biocompatible, and offer wide-ranging properties seen in living systems. The peptide backbone is enzymatically degradable while their side chain functionality can be modified to create an array of […]

Enabling High Capacity Anodes and Cathodes for Li-Ion Batteries

Abstract: Small molecules offer a unique opportunity to target structural and regulatory elements in therapeutically relevant RNAs, but understanding functional selectivity has been a recurrent challenge in small molecule:RNA recognition.  In particular, RNAs tend to be more dynamic and offer less chemical functionality than proteins, and biologically active ligands must compete with the highly abundant […]

Super-Resolution imaging of plasmonic Near-fields: Overcoming Emitter Mislocalizations

“Quantifying the Actin Cytoskeleton: A non-invasive image quantification tool to identify and track sub-cellular processes in real-time”