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Small molecule inhibitors of 15-prostaglandin dehydrogenase promote tissue repair and regeneration

Abstract: Prostaglandin E2 promotes tissue repair and regeneration in multiple tissues. Small molecule inhibitors of the PGE2-degrading enzyme, 15-prostaglandin dehydrogenase, could elevate PGE2 levels in vivo with applications in multiple disease contexts. We have discovered two chemical series of enzyme inhibitors. Medicinal chemistry efforts have led to sub-nM inhibitors with excellent bioavailability and physicochemical properties. […]

Chem 278: Prof. Cunjiang Yu

“Rubbery Electronics” Abstract: Seamlessly merging electronics with biology is of imminent importance in addressing grand societal challenges in health and joy of living. However, the main challenge lies in the huge mechanical mismatch between the current form of rigid electronics and the soft nature of biology. This talk will present a new type of electronics, […]

Cancelled Chem 218 Student Exit Seminar: Arundhati Deshmukh

Cancelled “Tuning the Excitonic Properties of 2-Dimensional Molecular Aggregates across the Visible and Shortwave Infrared” Molecular aggregates are non-covalent self-assemblies of chromophores wherein transition dipole moments of individual molecules couple coherently over long distances, forming delocalized excitons. This imparts exciting photophysical properties such as extreme blue or red shifts (seen in H- or J-aggregates respectively), […]

Theoretical Chemistry Seminar – Predicting and Controlling Correlated Light-Matter Interactions – Prof. Prineha Narang, Harvard University

Predicting and Controlling Correlated Light-Matter Interactions Quantum systems host spectacular excited-state effects, but many of these phenomena remain challenging to control and, consequently, technologically under-explored. My research, therefore, focuses on how quantum systems behave, particularly away from equilibrium, and how we can harness these effects1. By creating predictive approaches to study dynamics, decoherence and photo-induced […]

OCDS Prof. Tanja Ćuk

Resolving a catalytic mechanism at an electrode surface with high time-resolution:  Experimental identification of theoretical descriptors Abstract: Catalytic mechanisms at electrode surfaces guide the development of electrochemically-controlled energy storing reactions and chemical synthesis. The intermediate steps of these mechanisms are challenging to identify experimentally, but are critical to understanding the speed, stability, and selectivity of […]

Chem 218 Student Exit Seminar: Mary Grumbles

“Strategies for Modulating Stabilities of Soft and Hard Hybrid Materials with Boron Clusters” Carbon chemistry is ubiquitous across the development of modern materials. In comparison, use of boron building blocks is underdeveloped, owing to the historic instability of simple boranes. Polyhedral boranes, however, fundamentally differ from their borane precursors and exhibit exceptional chemical stability as […]

Recent progress in the discovery of non-hormonal male contraceptive agents

Abstract: There is a global need for novel contraceptive methods because worldwide about 40% of pregnancies are still unintended, about 42 million pregnancies are terminated by abortion, and 658 women per day die of pregnancy-related problems in the US (CDC 2020). While many contraceptive options exist for women, fewer are available for men. Testosterone-based contraceptives […]

Medicinal Chemistry and Pharmacology of Antivirals Targeting Influenza Virus, Enterovirus D68, and SARS-CoV-2

Abstract: Respiratory viruses pose a persistent threat to public health and global economy. However, there is a lack of effective antiviral countermeasures against many of these highly transmissible pathogens. In this presentation, I will present a few projects on the development of small molecule antivirals against the influenza virus, enterovirus D68 (EV-D68), and SARS-CoV-2. Throughout […]