Abstract: SARS-CoV2, the causative agent of the COVID-19 pandemic, is an RNA virus that has efficient human to human transmission and carries significant morbidity and mortality for vulnerable patient populations. Remdesivir (Veklury®) is a broad-spectrum inhibitor of RNA viruses and the first agent to be approved for the treatment of COVID-19. The seminar will introduce […]
"Metabolic control of post-translational modifications"
First-Principles Materials Prediction: From Sustainability to the Quantum Information Age Theory-guided materials design is vital to the advancement of sustainability and quantum information science. First-principles theory entirely based on quantum mechanics without prior input parameters is the perfect tool. In order to reliably predict exotic quantum materials and out-of-equilibrium processes, many-body physics and quantum kinetic […]
The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday, February 9th, 2021 at 1:00 PM. We are pleased to invite all students, postdocs, faculty, and staff.
Abstract: Prostaglandin E2 promotes tissue repair and regeneration in multiple tissues. Small molecule inhibitors of the PGE2-degrading enzyme, 15-prostaglandin dehydrogenase, could elevate PGE2 levels in vivo with applications in multiple disease contexts. We have discovered two chemical series of enzyme inhibitors. Medicinal chemistry efforts have led to sub-nM inhibitors with excellent bioavailability and physicochemical properties. […]
“Rubbery Electronics” Abstract: Seamlessly merging electronics with biology is of imminent importance in addressing grand societal challenges in health and joy of living. However, the main challenge lies in the huge mechanical mismatch between the current form of rigid electronics and the soft nature of biology. This talk will present a new type of electronics, […]
Cancelled “Tuning the Excitonic Properties of 2-Dimensional Molecular Aggregates across the Visible and Shortwave Infrared” Molecular aggregates are non-covalent self-assemblies of chromophores wherein transition dipole moments of individual molecules couple coherently over long distances, forming delocalized excitons. This imparts exciting photophysical properties such as extreme blue or red shifts (seen in H- or J-aggregates respectively), […]
“De novo design of function in water-soluble and membrane proteins”
Predicting and Controlling Correlated Light-Matter Interactions Quantum systems host spectacular excited-state effects, but many of these phenomena remain challenging to control and, consequently, technologically under-explored. My research, therefore, focuses on how quantum systems behave, particularly away from equilibrium, and how we can harness these effects1. By creating predictive approaches to study dynamics, decoherence and photo-induced […]
“Programmable transcriptional memory by CRISPR epigenome editing”
Resolving a catalytic mechanism at an electrode surface with high time-resolution: Experimental identification of theoretical descriptors Abstract: Catalytic mechanisms at electrode surfaces guide the development of electrochemically-controlled energy storing reactions and chemical synthesis. The intermediate steps of these mechanisms are challenging to identify experimentally, but are critical to understanding the speed, stability, and selectivity of […]
“Strategies for Modulating Stabilities of Soft and Hard Hybrid Materials with Boron Clusters” Carbon chemistry is ubiquitous across the development of modern materials. In comparison, use of boron building blocks is underdeveloped, owing to the historic instability of simple boranes. Polyhedral boranes, however, fundamentally differ from their borane precursors and exhibit exceptional chemical stability as […]
