Dr. Bae Flyer
Abstract: The synthesis of natural products is motivated by their potent biological effects, enigmatic biosynthetic origins, and complex molecular structures. Computational tools such as density functional theory and machine learning can provide mechanistic insights and predict reactivity in silico to inform synthetic campaigns. In addition, computational tools and predictive analytics can guide the development and application […]
Title: How does protein synthesis start in eukaryotes?
Strain is a foundational concept in organic chemistry. Its presence can transform an inert molecule into one with exciting properties, or steer a reaction toward a single product with exquisite control. Understanding—and importantly, predicting—the delicate balance between strain and reactivity will enable the full potential of strain to be harnessed for drug discovery, materials chemistry, […]
Title: Targeting Spike Glycans to Inhibit Viral Entry
Prof. Yoon Flyer Stereocontrol in Photochemical Synthesis Abstract: Photochemistry is intriguing as a synthetic tool because the absorption of light by an organic molecule results in the formation of exceptionally energetic reactive intermediates that can react in ways that are inaccessible to ground-state molecules. However, this high reactivity is also a challenge for stereoselective synthesis: […]
Title: TBD Abstract: TBD
Flyer: Sarah Keane Flyer Title: Structure of pre-miR-31 reveals an active role in Dicer processing Abstract: As an essential post-transcriptional regulator of gene expression, microRNA (miR) levels must be strictly maintained. The biogenesis of many, but not all, miRs is mediated by trans-acting protein partners through a variety of mechanisms, including remodeling of the RNA […]
Dr. Jovanovic Flyer Title: "Delocalized Bonding in Extended Systems: From Molecules to Quantum Materials" Abstract: A long list of words attached to extensions of two-center two-electron bonding, such as conjugation, aromaticity, electron-deficient, and electron-rich bonding, testifies to the ubiquity of electron delocalization and its importance in chemistry. Delocalization certainly has consequences – in spectroscopic, ionization, […]
Title: Cationic indium in catalysis: Generation of functionalized copolymers from commodity monomers Abstract: Cationic indium complexes are rare in the field of catalysis. We have developed families of cationic indium complexes supported by tridentate and tetradentate aminophenolate ligands which show reactivity towards cyclic esters, cyclic ethers, and copolymerizations with CO 2. We show that, depending […]