Dr. Ichikawa Flyer Title: Natural Recognition Motifs for the E3 Ligase Adapter Cereblon Abstract: Understanding the biology of drug target proteins is essential to enhance drug discovery efforts and mechanistic studies. The clinical drugs thalidomide and its derivatives, known as immunomodulatory drugs (IMiDs), are recognized by a conserved binding domain on the E3 ligase adapter […]
Michael Lawson Seminar Title: Defining the Pathways of Eukaryotic Translational Quality Control Abstract: My research examines how protein synthesis concludes on normal and defective mRNAs. Understanding how these processes are choregraphed is crucial for human health; for example, 11% of all heritable human diseases are caused by premature stop codons. As a postdoctoral fellow, I […]
Dr. Bae Flyer
Abstract: The synthesis of natural products is motivated by their potent biological effects, enigmatic biosynthetic origins, and complex molecular structures. Computational tools such as density functional theory and machine learning can provide mechanistic insights and predict reactivity in silico to inform synthetic campaigns. In addition, computational tools and predictive analytics can guide the development and application […]
Title: How does protein synthesis start in eukaryotes?
Strain is a foundational concept in organic chemistry. Its presence can transform an inert molecule into one with exciting properties, or steer a reaction toward a single product with exquisite control. Understanding—and importantly, predicting—the delicate balance between strain and reactivity will enable the full potential of strain to be harnessed for drug discovery, materials chemistry, […]
Title: Targeting Spike Glycans to Inhibit Viral Entry
Prof. Yoon Flyer Stereocontrol in Photochemical Synthesis Abstract: Photochemistry is intriguing as a synthetic tool because the absorption of light by an organic molecule results in the formation of exceptionally energetic reactive intermediates that can react in ways that are inaccessible to ground-state molecules. However, this high reactivity is also a challenge for stereoselective synthesis: […]
Title: TBD Abstract: TBD
Flyer: Sarah Keane Flyer Title: Structure of pre-miR-31 reveals an active role in Dicer processing Abstract: As an essential post-transcriptional regulator of gene expression, microRNA (miR) levels must be strictly maintained. The biogenesis of many, but not all, miRs is mediated by trans-acting protein partners through a variety of mechanisms, including remodeling of the RNA […]
