Abstract: The process development of a BACE-1 inhibitor is described. In order to address major safety and scalability limitations in the Discovery synthesis, two novel reactions were developed. The discovery, development, […]
Abstract:The selective introduction of functional groups at the positions of typically unreactive C-H bonds has been a longstanding challenge in catalysis. To this end, our group has developed practical methods […]
"Simulating linear and nonlinear optical spectra for chromophores in the condensed phase"
Panelist: Prof. Jennifer Casey Dept. of Chemistry and Biochemistry University of California, Los Angeles & Prof. Jay Foley Dept. of Chemistry William Paterson University & Prof. Jacob Olshansky Dept. of […]
Evan Maltz Wollman Group “Phenotypic Consequences of Gene Expression Variability”
“Imagining, Building, and Understanding the Next Generation Battery” Abstract: Electrochemical energy conversion and storage is critical for vehicle electrification and storing clean energy from intermittent sources (i.e. wind, solar) on […]
Abstract:The potential to use mechanochemistry, either in isolated polymers or in polymeric materials, to trigger a programmed, desirable covalent molecular response was first revealed only a decade or so ago. Since that time, covalent […]
Matthew Paul Agdanowski Yeates Group “The Development of an Imaging Scaffold for RNA Structural Analysis via Cryo-EM” and Janine Fu Loo Group “Targeting acyl-lysine modifications in the Rhodopseudomonas palustris proteome […]
“Ambient Electrochemical Functionalization of Methane with d0 early transition metal-oxo species” Abstract: The abundant yet widely distributed methane (CH4) resources demands an efficient conversion of CH4 into liquid chemicals at ambient conditions with […]
Abstract: Despite advances in high-throughput screening methods leading to a surge in the discovery of catalytic reactions, our knowledge of the molecular-level interactions in the rate- and selectivity-determining steps of catalytic […]
