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Prioritizing the patient – The discovery of lorlatinib, a macrocyclic ALK inhibitor for the treatment of resistant and metastatic NSCLC

Abstract: Primary and secondary mutations in anaplastic lymphoma kinase (ALK) are oncogenic. Insights into ALK acquired resistance were used to define a drug design strategy that led to the discovery of lorlatinib (Lorbrena; PF-06463922), a novel ATP-competitive macrocyclic inhibitor of ALK and ROS1 kinases. Structure based drug design, lipophilic efficiency and physicochemical property-based optimization provided […]

Chem 268: Prof. Tanja Kortemme

"Switches, sensors, and new shapes: from design of new functions to cellular consequences of allostery"

Special Bio-Inorganic Chemistry Seminar

"Structural Evidence for Dynamic Nitrogenase Metalloclusters" Abstract: Nitrogenase catalyzes dinitrogen reduction to ammonia and is the only enzyme capable of supplying the world with a reduced form of ‘N’ that can be directly incorporated into biomolecules such as DNA and proteins. The most well-studied nitrogenase, molybdenum nitrogenase, consists of two component proteins, the Fe protein […]

“The Journey of Remdesivir from Respiratory Syncytial Virus to COVID-19”

Abstract: SARS-CoV2, the causative agent of the COVID-19 pandemic, is an RNA virus that has efficient human to human transmission and carries significant morbidity and mortality for vulnerable patient populations. Remdesivir (Veklury®) is a broad-spectrum inhibitor of RNA viruses and the first agent to be approved for the treatment of COVID-19. The seminar will introduce […]

First-Principles Materials Prediction: From Sustainability to the Quantum Information Age – Prof. Yuan Ping, UCSC

First-Principles Materials Prediction: From Sustainability to the Quantum Information Age Theory-guided materials design is vital to the advancement of sustainability and quantum information science. First-principles theory entirely based on quantum mechanics without prior input parameters is the perfect tool. In order to reliably predict exotic quantum materials and out-of-equilibrium processes, many-body physics and quantum kinetic […]

NSF Center for Integrated Catalysis Webinar Series

The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday, February 9th, 2021 at 1:00 PM.  We are pleased to invite all students, postdocs, faculty, and staff.

Small molecule inhibitors of 15-prostaglandin dehydrogenase promote tissue repair and regeneration

Abstract: Prostaglandin E2 promotes tissue repair and regeneration in multiple tissues. Small molecule inhibitors of the PGE2-degrading enzyme, 15-prostaglandin dehydrogenase, could elevate PGE2 levels in vivo with applications in multiple disease contexts. We have discovered two chemical series of enzyme inhibitors. Medicinal chemistry efforts have led to sub-nM inhibitors with excellent bioavailability and physicochemical properties. […]

Chem 278: Prof. Cunjiang Yu

“Rubbery Electronics” Abstract: Seamlessly merging electronics with biology is of imminent importance in addressing grand societal challenges in health and joy of living. However, the main challenge lies in the huge mechanical mismatch between the current form of rigid electronics and the soft nature of biology. This talk will present a new type of electronics, […]

Cancelled Chem 218 Student Exit Seminar: Arundhati Deshmukh

Cancelled “Tuning the Excitonic Properties of 2-Dimensional Molecular Aggregates across the Visible and Shortwave Infrared” Molecular aggregates are non-covalent self-assemblies of chromophores wherein transition dipole moments of individual molecules couple coherently over long distances, forming delocalized excitons. This imparts exciting photophysical properties such as extreme blue or red shifts (seen in H- or J-aggregates respectively), […]