Deming, Timothy J.


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Division
Organic
Title
Faculty
Professor
Specialties
Organic
Materials

Contact Information

Email
Office
Engineering V 5121C
(310) 267-4450
Lab
Engineering V 5121
(310) 204-5956

Short Biography

Timothy Deming received his B.S. in Chemistry fom the University of California, Irvine in 1989, and his Ph.D. in Chemistry from the University of California, Berkeley, in 1993. After a NIH postdoctoral fellowship at the University of Massachusetts, Amherst, he joined the faculty in the Materials Department at the University of California, Santa Barbara in 1995. Here he held a joint appointment in the Materials and Chemistry Departments where he was promoted to Associate Professor in 1999 and Full Professor in 2003. In 2004 he moved to UCLA as a Professor of Bioengineering and was also appointed as Professor of Chemistry and Biochemistry in 2005. He served as the Chair of the Department of Bioengineering from 2006-2011.

Biography

Timothy J. Deming received a B.S. in Chemistry fom the University of California, Irvine in 1989, and graduated with a Ph.D. in Chemistry from the University of California, Berkeley, under Bruce Novak in 1993. After a NIH postdoctoral fellowship at the University of Massachusetts, Amherst with David Tirrell, he joined the faculty in the Materials Department at the University of California, Santa Barbara in 1995. Here he held a joint appointment in the Materials and Chemistry Departments where he was promoted to Associate Professor in 1999 and Full Professor in 2003. His appointment is now as the Chair of the Bioengineering Department at the University of California, Los Angeles. Current research interests include polypeptide synthesis, self-assembly of block copolypeptides, and biological activity of polypeptides, for which he has received young investigator awards from the National Science Foundation, the Office of Naval Research, The Arnold and Mabel Beckman Foundation, the Alfred P. Sloan Foundation, the Camille and Henry Dreyfus Foundation, the Materials Research Society, and the IUPAC Macromolecular Division.

Research Interest

Research in the Deming group is focused on synthesis, processing, characterization and evaluation of biological and biomimetic materials based on polypeptides. These materials are being studied since they can be prepared from renewable resources, they can be biocompatible and biodegradable, and possess unique self-assembling properties. We utilize innovative chemistry techniques to synthesize materials with properties that rival the complexity found in biological systems. The polymers are then processed into ordered assemblies, which are characterized for both nanoscale structure as well as biological function. This interdisciplinary approach stimulates innovations and ideas which direct this research into new, exciting areas.

Honors & Awards

Fellow of the American Institute for Medical and Biological Engineering (AIMBE) 2010

Herbert Newby McCoy Award (UCLA Dept. of Chem. & Biochem.) 2008

IUPAC Macromolecular Division Young Scientist Award 2004

MRS Young Investigator Award 2003

Camille Dreyfus Teacher-Scholar 2000

3M Non-Tenured Faculty Award 1999

Beckman Young Investigator Award 1998-2000

Alfred P. Sloan Research Fellow 1998-2000

National Science Foundation CAREER Award 1997-2001

Office of Naval Research Young Investigator Award 1996-1999

University of California, Regents Junior Faculty Fellow 1996

ACS Unilever Award for Outstanding Graduate Research in Polymer Chemistry 1994

NIH National Research Service Award Postdoctoral Fellow 1993 - 1995

Publications

  • Analogues of Poly(l-phosphoserine) via Living Polymerization of Phosphonate-Containing N-Carboxyanhydride Monomers
    Yakovlev, I.; Deming, T. J.
    ACS Macro Lett., 2014, 3, 378-381.
  • Multimodal switching of conformation and solubility in homocysteine derived polypeptides
    Kramer, J. R.; Deming, T. J.
    J. Amer. Chem. Soc., 2014, 136, 5547–5550.
  • Preparation and development of block copolypeptide vesicles and hydrogels for biological and medical applications
    Deming, T. J.
    WIREs Nanomed. Nanobiotechnol., 2014, 6, 283-297.
  • Synthesis and self-assembly of well defined block copolypeptides via controlled NCA polymerization
    Deming, T. J.
    in Hierarchical Macromolecular Structures: 60 Years after the Staudinger Nobel Prize II
    Percec, V. (Ed.), Adv. Polymer Sci., 2013, 262, 1-37.
  • Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system
    Zhang, S.; Anderson, M. A.; Ao, Y.; Khakh, B. S.; Deming, T. J.; Sofroniew, M. V.
    Biomaterials, 2014, 35, 1989-2000.
  • Recent advances in glycopolypeptide synthesis
    Kramer, J. R.; Deming, T. J.
    Polym. Chem., 2014, 5, 671-682.
  • Enzyme-triggered cargo release from readily prepared copolypeptide vesicles
    Rodriguez, A. R.; Kramer, J. R.; Deming, T. J.
    Biomacromolecules, 2013, 14, 3610-3614.
  • Soluble, clickable polypeptides from azide containing NCA monomers
    Rhodes, A. J.; Deming, T. J.
    ACS Macro Lett., 2013, 2, 351-354.
  • Reversible chemoselective tagging and functionalization of methionine containing peptides
    Kramer, J. R.; Deming, T. J.
    Chem. Commun., 2013, 49, 5144 - 5146.
  • Dynamic Self-assembly of Discrete Metal Complexes in Aqueous Solution via Block Copolypeptide Amphiphiles
    Kuroiwa, K.; Masaki, Y.; Koga, Y.; Deming, T. J.
    Int. J. Molecular Sci., 2013, 14, 2022- 2035.
  • Endocytosis and Intracellular Trafficking Properties of Transferrin-Conjugated Block Copolypeptide Vesicles
    Choe, U-J.; Rodriguez, A. R.; Lee, B. S.; Knowles, S.; Wu, A. M.; Deming, T. J.; Kamei, D. T.
    Biomacromolecules, 2013, 14, 1458-1464.
  • Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology
    Kramer, J. R.; Rodriguez, A. R.; Choe, U-J.; Kamei, D. T.; Deming, T. J.
    Soft Matter, 2013, 9, 3389-3395.
  • Characterization of minimization of block copolypeptide Vesicle toxicity using different Hydrophobic Chain Lengths". Choe, U-J.; Rodriguez, A. R.; Li, Z.; Boyarskiy, S.; Deming, T. J.; Kamei, D. T.
    Macromolecular Chem. Phys., 2013, 214, 994-999.
  • Transfection of mammalian cells using block copolypeptide vesicles
    Sun, V.Z.; Choe, U-J.; Rodriguez, A.R.; Deming, T.J.; Kamei, D.T.
    Macromolecular Biosci., 2013, 13, 539-550.
  • Engineering Polypeptide Coatings to Augment Gene Transduction and in vivo Stability of Adenoviruses
    Jiang, Z.K.; Koh, S.B.S; Sato, M.; Atanasov, I.C.; Johnson, M.; Zhou, Z.H.; Deming, T.J.; Wu, L.J.
    Controlled Rel., 2013, 166, 75-85.
  • Tandem Catalysis for the Preparation of Cylindrical Polypeptide Brushes". Rhodes, A.J.; Deming, T.J.
    Amer. Chem. Soc., 2012, 134, 19463-19467.
  • Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypepetide hydrogel depots
    Song, B.; Song, J.; Zhang, S.; Anderson, M. A.; Ao, Y.; Yang, C-Y.; Deming T.J.; Sofroniew, M.V.
    Biomaterials, 2012, 33 9105-9116
  • Preparation of Multifunctional and Multireactive Polypeptides via Methionine Alkylation
    Kramer, J. R.; Deming, T. J.
    Biomacromolecules, 2012, 13, 1719-1723.
  • Glycopolypeptides with a redox triggered helix to coil transition
    Kramer, J. R.; Deming, T. J.
    J. Amer. Chem. Soc., 2012, 134, 4112-4115.
  • Fine Tuning of Vesicle Assembly and Properties Using Dual Hydrophilic Triblock Copolypeptides
    Rodriguez, A. R.;  Choe, U-J.; Kamei, D. T.; Deming, T. J.
    Macromolecular Biosci., 2012, 12, 805-811.
  • Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides
    Deming, T. J. in Polymer Science: A Comprehensive Reference,
    Matyjaszewski, K. and Möller, M. (eds.),Elsevier BV, 2012, 4, 427-429.
  • Peptide-Based Materials
    Deming, T. J. (Ed.)
    Top. Curr. Chem., 2012, 310, 1 – 171.
  • Synthesis of Polypeptides by Ring-Opening Polymerization of a-Amino Acid N-Carboxyanhydrides
    Cheng, J.; Deming, T. J.
    Top. Curr. Chem., 2012, 310, 1 – 26.