Flyer: Dr. Alec Follmer Flyer Title: Controlling C-H Bond Activation: Structural and Dynamic Regulation of Reactive Intermediates in Cytochrome P450 Catalysis Abstract: From metabolism and detoxification to the biosynthesis of steroids and natural products, cytochromes P450 (P450s) are heme-containing enzymes that utilize O2 for the activation of C–H bonds and serve ubiquitous roles in nearly […]

Modern drug discovery has benefited from advancements in chemical reaction development. For example, C–H functionalization reactions has transformed how synthetic chemists approach the retrosynthetic analysis of bioactive compounds. Despite recent advances, the development of site-selective reactions remains a grand challenge in metal-catalyzed C–H functionalization. Typical retrosynthetic analysis results in simplified fragments by the removal of […]