Maynard, Heather D.


WebsiteHome URL
Division
Organic
Title
Faculty
Professor
Dr. Myung Ki Hong Endowed Chair in Polymer Science
Specialties
Organic
Materials
Nanoscience
Synthesis
Analytical

Contact Information

Email
Office
Molecular Sciences Building 4505B
(310) 267-5162
Lab
Molecular Sciences Building 4234
(310) 825-7385

Short Biography

Professor Maynard received her B.S. degree in Chemistry with Honors in 1992 at the University of North Carolina at Chapel Hill, her M.S. degree in Materials Science in 1995 at the University of California, Santa Barbara, and her Ph.D. in Chemistry in 2001 from the California Institute of Technology. After working as an American Chemical Society Postdoctoral Fellow at the Swiss Federal Institute of Technology (ETH) and University of Zurich, she joined the faculty at UCLA in 2002.

Biography

Heather D. Maynard is the Dr. Myung Ki Hong Professor in Polymer Science in the Department of Chemistry and Biochemistry and the California NanoSystems Institute at UCLA. Maynard is a leader in the area of protein-polymer conjugates, which are important therapeutics for a variety of diseases. She develops new synthetic methods to make the materials, invents new polymers to improve properties such as stability, and demonstrates preclinical efficacy of her conjugates with an eye towards translation for human health. Maynard also works in the area of smart materials for precision medicine: materials that respond to disease states in the body. Maynard’s research and teaching have been recognized by numerous awards, including most recently the Bioconjugate Chemistry Lectureship Award, the American Chemical Society Arthur Cope Scholar Award, the UCLA Student Development Diversity, Equity and Inclusion Award, and election as an American Association for the Advancement of Science (AAAS) Fellow. Maynard is also an American Chemical Society POLY and PMSE, Leverhulme, Kavli Frontiers, and Royal Society of Chemistry Fellow, was a Fulbright Specialist in New Zealand, and a member of the US Defence Science Study Group.  Maynard received her PhD from the California Institute of Technology and was an American Cancer Society Postdoctoral fellow at the Swiss Federal Institute of Technology (ETH). 

Research Interests

The Maynard research group is interested in the synthesis and application of protein-polymer conjugates and smart materials.  There are three main research thrusts within the group.

1) New syntheses of protein-polymer conjugates are developed and applied to prepare therapeutic protein-polymer conjugates.  Conjugates are studied for therapeutic efficacy and safety with a focus on drugs used to treat diabetes.  We also rationally design and synthesize polymers that stabilize proteins to stressors encountered during the production, storage, and shipping conditions.  

2) Our group prepares stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications.  These materials are responsive to a variety of triggers such as pH, reducing conditions, temperature, glucose, and enzymes that can be tuned based on their chemistry for various applications in medicine including for diabetes and cancer.  

3)  Current solutions to enhance food yields are expensive, inefficient, and/or wasteful.  The Maynard Lab creates polymers and hydrogels to encapsulate, stabilize, and release vulnerable compounds and proteins, overall increasing the efficiency of their use.  We also create materials to reduce water use for agriculture under drought conditions.

 

Honors & Awards

  • Bioconjugate Chemistry Lectureship Award, American Chemical Society, 2019
  • UCLA Student Development Diversity, Equity and Inclusion Award, 2018
  • Arthur C. Cope Scholar Award, American Chemical Society, 2018
  • Fellow of the American Association for the Advancement of Science (AAAS), 2018,
  • Fulbright Specialist, New Zealand, 2017
  • Polymer Materials: Science and Engineering American Chemical Society Fellow, 2017
  • Dr. Myung Ki Hong Endowed Chair in Polymer Science, 2017-present
  • Defense Science Study Group Member, 2016-2018
  • Leading Edge Lecturer, City of Hope, 2015
  • AAPS Lecturer, University of Utah, 2015
  • Herbert Newby McCoy Award for Outstanding Research, 2013
  • POLY Fellow Award of the American Chemical Society, 2013
  • Eastman Chemical Company Lecturer, University of Akron, 2013
  • Leverhulme Fellow 2012 Fellow of the Royal Society of Chemistry, 2011
  • Kavli Frontiers Fellow 2011 Walter F. Enz Lecturer, University of Kansas, 2008
  • Young Academic Investigators Symposium Lecturer, ACS, New Orleans, 2008
  • Hanson-Dow Award for Excellence in Teaching, 2007
  • Seaborg Award for Outstanding Research in Chemistry, 2007
  • NSF CAREER Award, 2007-2012
  • Selected as an Outstanding Emerging Investigator in Materials Chemistry, 2007
  • WCC ACS Lecturer, Southern Methodist University, 2006
  • Alfred P. Sloan Research Fellow, 2006-2008
  • Amgen New Faculty Award, 2004
  • Howard Reiss Career Development Chair, 2002-2007
  • American Cancer Society Postdoctoral Fellowship, 2000-2002
  • American Chemical Society Women’s Committee Travel Award, 1998
  • Dow Travel Fellowship Award, 1997
  • Graduation with Honors from University of North Carolina at Chapel Hill, 1992
  • Bausch & Lomb Science Award for Excellence in Chemistry, 1987
  • Soroptimist Society Award 

 

Publications

 

2020

  • Wang, Y; Langley, R. J.; Tamshen, K.; Jamieson, S. M.; Lu, M.; Maynard, H. D.; Perry, J. K. “Long-Acting Human Growth Hormone Receptor Antagonists Produced in E. coli and Conjugated with Polyethylene Glycol.” Bioconjugate Chem. 2020, DOI: 10.1021/acs.bioconjchem.0c00208 [LINK]
  • Pelegri-O’Day, E. M.; Bhattacharya, A.; Theopold, N.; Hoon Ko, J.; Maynard, H.D. “Synthesis of Zwitterionic and Trehalose Polymers with Variable Degradation Rates and Stabilization of Insulin.” Biomacromolecules, 2020, DOI: 10.1021/acs.biomac.0c00133 [LINK]
  • Messina, M. S.; Maynard, H. D. "Modification of Proteins Using Olefin Metathesis," Mater. Chem. Front. 2020, DOI: 10.1039/C9QM0049. [LINK]
  • Messina, M. S.; Messina, K. M. M.; Bhattacharya, A,; Montgomery, H. R.; Maynard, H. D. "Preparation of Biomolecule-Polyerm Conjugates by Grafting-From Using ATRP, RAFT, or ROMP," Prog. Polym. Sci. 2020, 100, 1-25. DOI: 10.1016/j.progpolymsci.2019.101186. [LINK]

2019

  • Miang, C.; Zhu, X.; Messina, M.S.; Poon, S.; Yu, X.; Maynard, H.D.; Jassby, D. "Electrically Mediated Membrane Pore Gating via Grafted Polymer Brushes," ACS Mater. Lett. 2019, 1,6, 647-654. [LINK]
  • Qian, E. A.; Han, Y.; Messina, M. S.; Maynard, H. D.; Kral, P.; Spokoyny, A. M. "Multivalent Cluster Nanomolecules for Inhibiting Protein-Protein Interactions," Bioconjugate Chem. 2019, 30, 10, 2594-2603. [LINK]
  • Fulcher, J. A.; Tamshen, K.; Wollenburg, A.; Kickhoefer, V.A.; Mrazek, J.; Ibarrondo, F. J.; Anton, P. A.; Rome, L. H.; Maynard, H. D.; Deming, T.; Yang, O.O. "Human Vault Nonoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection," Bioconjugate Chem. 2019, 30, 2216-2227. [LINK]
  • Panescu, P. H.; Ko, J. H.; Maynard, H. D. “Scalable Trehalose Hydrogel Synthesis for Stabilization and Release of Active Animal Feed Enzymes,” Macromol. Mater. Eng. 2019,1800781, 1-7. [LINK]
  • Messina, M. S.; Graefe, C.; Chong, P.; Ebrahim, O. M.; Pathuri, R. S.; Bernier, N. A.; Mills, H. A.; Rheingold, A. L.; Frontiera, R. R.; Maynard, H. D.; Spokoyny, A. M. “Carborane RAFT Agents as Tunable and Functional Molecular Probes for Polymer Materials,” Polym. Chem. 2019, 10, 1660-1667. [LINK]
  • Ko, J. H.; Bhattacharya, A.; Terashima, T.; Sawamato, M.; Maynard, H. D. “Amphiphilic Fluorous Random Copolymer Self-Assembly for Encapsulation of a Fluorinated Agrochemical,” J. Poly. Sci. A Poly. Chem. 2019, 57, 352-359. [LINK]

2018

  • Ko, J. H.; Maynard, H. D. “A Guide to Maximizing the Therapeutic Potential of Protein-Polymer Conjugates by Rational Design,” ChemSocRev, 2018, 47, 8998-9014. [LINK]
  • *Chosen for cover of that issue [LINK]
  • Deming, T. J.; Klok, H. –A.; Armes, S. P.; Becker, M. L.; Champion, J. A.; Chen, E. Y. –X.; Heilshorn, S. C.; van Hest, J. C. M.; Irvine, D. J.; Johnson, J. A.; Kiessling, L. L.; Maynard, H. D.; Olvera de la Cruz, M.; Sullivan, M. O.; Tirrell, M. V.; Anseth, K. S.; Lecommandoux, S.; Percec, S.; Zhong, Z.; Albertsson, A. –C. “Polymers at the Interface with Biology,” Biomacromolecules, 2018, 19, 3151-3162. [LINK]
  • Pelegri-O'Day, E.M; Matsumoto, N.M.; Tamshen, K.; Raftery, E.D.; Lau, U.L.; Maynard, H.D., "PEG Analogs Synthesized by Ring-Opening Metathesis Polymerization for Reversible Bioconjugation," Bioconjugate Chem. 2018, 29, 3739-3745. [LINK]
  • Messina, M. S.; Stauber, J. M.; Waddington, M. A.; Rheingold, A. L.; Maynard, H. D.; Spokoyny, A. M.“Organometallic Au(III) Reagents for Cysteine Arylation,” J. Am. Chem. Soc. 2018, 140, 7065-7069.[LINK]
  • Lee, J., -W., Dai, Z., Lee, C., Lee, H. M., Han, T-. H., De Marco, N., Lin, O., Choi, C. S., Koh, J., Di Carlo, D., Ko, J. H., Maynard, H. D., Yang, Y.,“Tuning Molecular Interactions for Highly Reproducible and Efficient Formamidinium Perovskite Solar Cells via Adduct Approach,” J. Am. Chem. Soc. 2018, 140, 6317-6324.[LINK]
  • Lee, J., Ko, J. H., Mansfield, K.M., Nauka, P. C., Bat, E., Maynard, H. D., “Glucose-Responsive Trehalose Hydrogels for Insulin Stabilization and Delivery,” Macromol. Biosci, 2018, 18, 1700372, 1-7. [LINK]
  • Mansfield, K.M., Maynard, H. D., “Site-Specific Insulin-Trehalose Glycopolymer Conjugate by Grafting From Strategy Improves Bioactivity,” ACS Macro Lett, 2018, 7, 324-329.[LINK]
  • Boehnke, N.; Kammeyer, J.; Damoiseaux, R., Maynard, H. D. “Trehalose Nanoparticles for Glucagon Stabilization,” Adv. Funct. Mater. 2018, 28, 1705475, 1-11. [LINK]
  • Lau, U. Y.; Pelegri-O’Day, E. M.; Maynard, H. D. “Synthesis and Evaluation of a Degradable Trehalose Glycopolymer Prepared by RAFT Polymerization,” Macro. Rapid Comm. 2018, 39, 1700652, 1-6. [LINK]

2017

  • Ko, J. H.; Terashima, T.; Sawamoto, M.; Maynard, H. D.; "Fluorous Comonomer Modulates the Reactivity of Cyclic Ketene Acetal and Degradation of Vinyl Polymers,” Macromolecules, 2017, 50, 9222-9232.[LINK]
  • Boehnke, N.; Maynard, H. D.; "Design of Modular Dual-Enzyme Responsive Peptides," Peptide Science, 2017, 108, 1-6.[LINK]
  • Paluck, S. J.; Maynard, H. D.; "Structure Activity Relationship of Heparin Mimicking Polymer p(SS-co-PEGMA): Effect of Sulfonation and Polymer Size on FGF2 Receptor Binding," Polym. Chem. 2017, 8, 4548-4556.[LINK]
  • Messina, M. S.; Ko, J. H.; Yang, Z.; Strouse, M. J.; Houk, K. N.; Maynard, H. D.; "Effect of Trehalose Polymer Regioisomers on Protein Stabilization," Polym. Chem. 2017, 4781-4788.[LINK]
  • Brown, C. L.; Barbee, M. H.; Ko, J. H.; Maynard, H. D.; Craig, S. L. "Writing Without Ink: A Mechanically and Photochemically Responsive PDMS Polymer for Science Outreach," J. Chem. Ed. 2017, 94, 1752-1755.[LINK]
  • Pelegri-O'Day, E. M.; Paluck, S. ; Maynard, H. D. “Substituted Polyesters by Thiol–Ene Modification: Rapid Diversification for Therapeutic Protein Stabilization,” J. Am. Chem. Soc. 2017, 139, 1145-1154.[LINK]
  • Liu, Y.; Lee, J. ; Mansfield, K. M.; Ko, J. H.; Sallam, S.; Wesdemiotis, C.; Maynard, H. D. “Trehalose Glycopolymer Enhances Both Solution Stability and Pharmacokinetics of a Therapeutic Protein,” Bioconjugate Chem. 2017, 28, 836-845.[LINK]
  • Medina, M. J.; Ko, J. H.; Maynard, H. D.; Garg, N. K. “Expanding the ROMP Toolbox: Synthesis of Air-Stable Benzonorbornadiene Polymers by Aryne Chemistry,” Macromolecules, 2017, 50, 580-586. [LINK]
  • Qian, E. A.; Wixtrom, A. I.; Axtell, J. C.; Saebi, A.; Wang, J. Y.; Jung, D.; Moully, E. H.; Mosallaei, D.; Chow, S.; Messina, M. S.; Rehak, P.; Han, Y.; Royappa, A. T.; Rheingold, A. L.; Maynard, H. D.; Král, P.; Spokoyny, A. M. “Atomically precise organomimetic cluster nanomolecules (OCNs) assembled via perfluoroaryl-thiol SNAr chemistry” Nature Chem. 2017.[LINK]

2016

  • Paluck, S. J.; Nguyen, T. H.; Maynard, H. D. “Heparin-Mimicking Polymers: Synthesis and Biological Applications,” Biomacromolecules, 2016, 17, 3417-3440. [LINK]
  • Vanparijs, N.; Nuhn, L.; Paluck, S. J.; Maynard, H. D.; De Geest, B. G. “Core and Shell Reactive Nanogels for Protein Conjugation via a Combination of RAFT Polymerization and Vinyl Sulfone Post-Modification,” Nanomedicine, 2016, 11, 2631-2645. [LINK]
  • Pelegri-O’Day, E. M.; Maynard, H. D. “Controlled Radical Polymerization as an Enabling Approach for the Next Generation of Protein-Polymer Conjugates,” Acc. Chem. Res. 2016, 49, 1777-1785. [LINK]
  • Koda, Y.; Terashima, T.; Maynard, H. D.; Sawamoto, M. “Protein Storage with Perfluorinated PEG Compartments in a Hydrofluorocarbon Solvent,” Polym. Chem. 2016, 7, 6694-6698. [LINK]
  • Paluck, S. J.; Nguyen, T. H.; Lee, J. P.; Maynard, H. D. “A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2),” Biomacromolecules, 2016, 17, 3386-3395. [LINK]
  • Shen, L.; Decker, C. G.; Maynard, H. D.; Levine, A. J., “Mean Time to Capture for Tethered Ligands and Its Effect on the Chemical Equilibrium of Bound Ligand Pairs,” Data in Brief, 2016, 8, 506-515. [LINK]
  • Messina, M. S.; Axtell, J. C.; Wang, Y.; Chong, P.; Wixtrom, A. I.; Kirlikovali, K. O.; Upton, B. M.; Hunter, B. H.; Shafaat, O. S.; Khan, S. I.; Winkler, J. R.; Gray, H. B.; Alexandrova, A. N.; Maynard, H. D.; Spokoyny, A. M. "Visible Light-Induced Olefin Activation using 3D Aromatic Boron-Rich Cluster Photooxidants," J. Am. Chem. Soc. 2016, 138, 6952-6955. [LINK]
  • Mancini, R. J.; Paluck, S. J.; Bat, E.; Maynard, H. D. "Encapsulated Hydrogels by E-Beam Lithography and Their Use in Enzyme Cascade Reactions," Langmuir, 2016, 32, 4043-4051. [LINK]
  • Nauka, P. N.; Lee, J.; Maynard, H. D. "Enhancing Conjugation Yield of Brush Polymer Protein-Polymer Conjugates by Increasing Linker Length at the Polymer End Group," Polym. Chem. 2016, 7, 2352-2357. [LINK]
  • Decker, C. G.; Wang, Y.; Paluck, S. J.; Shen, L.; Loo, J. A.; Levine, A. J.; Miller, L. S.; Maynard, H. D. "Fibroblast Growth Factor 2 Dimer with Superagonist Activity Improves Wound Healing," Biomaterials, 2016, 81, 157-168.[LINK]
  • Lorenzo, M. M.; Decker, C. G.; Kahveci, M. U.; Paluck, S. J.; Maynard, H. D. "Homodimeric Protein-Polymer Conjugates via the Tetrazine-trans-Cyclooctene Ligation," Macromolecules, 2016, 49, 30-37.[LINK]
  • Lau, U. Y.; Saxer, S. S.; Lee, J.; Bat, E.; Maynard, H. D. "Direct Write Protein Patterns for Multiplexed Cytokine Detection from Live Cells Using Electron Beam Lithography," ACS Nano, 2016, 10, 723-729. [LINK]

2015

  • Maynard, H. D., "Protein Modification in a Trice," Nature, 2015, 526, 646-647. [LINK]
  • Nguyen, T. H.; Paluck, S. J.; McGahran, A. J.; Maynard, H. D., "Poly(vinyl sulfonate) Facilitates bFGF-Induced Cell Proliferation," Biomacromolecules, 2015, 16, 2684-2692. [LINK]
  • Lin, E. W.; Maynard, H. D., "Grafting From siRNA as an Alternative Synthesis Route to siRNA-Polymer Conjugates," Macromolecules, 2015, 48, 5640-5647. [LINK]
  • Boehnke, N.; Cam, C.; Bat, E.; Segura, T.; Maynard, H. D., "Imine Hydrogels with Tunable Degradability for Tissue Engineering," Biomacromolecules, 2015, 16, 2101-2108. [LINK]
  • Lee, J.; Ko, J. H.; Lin, E.-W.; Wallace, P.; Ruch, F.; Maynard, H. D., "Trehalose hydrogels for stabilization of enzymes to heat," Polym. Chem. 2015, 6, 3443-3448. [LINK]
  • Bat, E.; Lee, J.; Lau, U. Y.; Maynard, H. D., "Trehalose glycopolymer resists allow direct writing of protein patterns by electron-beam lithography," Nat. Commun., 2015, 6, 6654. [LINK]
  • Matsumoto, N.M.; Buchman, G. W.; Rome, L. H.; Maynard, H. D., "Dual pH- and Temperature-Responsive Protein Nanoparticles," Eur. Polym. Journal, 2015, 69, 532-539. [LINK]
  • Decker, C. G.; Maynard, H. D., "Degradable PEGylated Protein Conjugates Utilizing RAFT Polymerization," Eur. Polym. Journal, 2015, 65, 305-312. [LINK]
  • Koda, Y.; Terashima, T.; Sawamoto, M.; Maynard, H. D., "Amphiphilic/Fluorous Random Copolymers as a New Class of Biocompatible Polymeric Materials for Protein Conjugation,"Polym. Chem. 2015, 6, 240-247. [LINK]

2014

  • Lin, E.-W.; Boehnke, N.; Maynard, H. D. "Protein-Polymer Conjugation via Ligand Affinity and Photoactivation of Glutathione S-Transferase" Bioconjugate Chem. 2014, 25, 1902-1909.* [LINK] *ACS Editor's choice
  • Pelegri-O'Day, E. M.; Lin, E.-W.; Maynard, H. D., "Therapeutic Protein-Polymer Conjugates: Advancing Beyond PEGylation," J. Am. Chem. Soc. 2014, 136, 14323-14332. [LINK]
  • Bat, E.; Lin, E.-W.; Saxer, S.; Maynard, H. D., "Morphing Hydrogel Patterns by Thermo-Reversible Fluorescence Switching," Macro. Rapid Commun. 2014, 35, 1260-1265. [LINK]
  • Upton, B. M.; Gipson, R. M.; Duhovic, S.; Lydon, B. R.; Matsumoto, N. M.; Maynard, H. D.; Diaconescu, P., "Synthesis of Ferrocene- Functionalized Monomers for Biodegradable Polymer Formation," Inorganic Chem. Frontiers, 2014, 1, 271-277. [LINK]
  • de la Rica, R.; Bat, E.; Herpoldt, K. L.; Xie, H.-n.; Bertazzo, S.; Maynard, H. D.; Stevens, M. M., "Nanoparticle Growth via Concentration Gradients Generated by Enzyme Nanopatterns,"Adv. Funct. Mater. 2014, 24, 3692-3698. [LINK]

2013

  • Tolstyka, Z. P.; Richardson, W.; Bat, E.; Stevens, C. J.; Parra, D. P.; Dozier, J. K.; Distefano, M. D.; Dunn, B.; Maynard, H. D., "Chemoselective Immobilization of Proteins by Microcontact Printing and Bioorthogonal Click Reactions," ChemBioChem, 2013, 14, 2464-2471. [LINK]
  • Maynard, H. D., "Protein in a Pill," Nature Chem. 2013, 5, 557-558. [LINK]
  • Lee, J.; Lin, E.-W.; Lau, U. Y.; Hedrick, J. L.; Bat, E.; Maynard, H. D., "Trehalose Glycopolymers as Excipients for Protein Stabilization," Biomacromolecules, 2013, 14, 2561-2569.[LINK]
  • Griffin, D. R.; Schlosser, J. L.; Lam, S. F.; Nguyen, T. H.; Maynard, H. D.; Kasko, A. M., "Synthesis of Photodegradable Macromers for Conjugation and Release of Bioactive Molecules,"Biomacromolecules, 2013, 14, 1199-1207. [LINK]
  • Alconcel, S. N. S.; Kim, S. H.; Tao, L.; Maynard, H. D., "Synthesis of Biotinylated Aldehyde Polymers for Biomolecule Conjugation," Macro. Rapid Commun. 2013, 34, 983-989. [LINK]
  • Nauka, P; Maynard, H.D., "Creative and Novel Applications of Poly(Ethylene Glycol)," The UCLA Undergraduate Science Journal. 2013, 76-81.
  • Matsumoto, N. M.; Gonzalez-Toro, D. C.; Chacko, R. T.; Maynard, H. D.; Thayumanavan, S., "Synthesis of Nanogel-Protein Conjugates," Polym. Chem. 2013, 4, 2464-2469. [LINK]
  • Thi H. Nguyen, Sung-Hye Kim, Caitlin G. Decker, Darice Y. Wong, Joseph A. Loo, and Heather D. Maynard, "A Heparin-Mimicking Polymer Conjugate Stabilizes Basic Fibroblast Growth Factor," Nat. Chem. 2013, 5, 221-227. [LINK]
  • Matsumoto, N. M.; Prabhakaran, P.; Rome, L. H.; Maynard, H. D., "Smart Vaults: Thermally-Responsive Protein Nanocapsules," ACS Nano, 2013, 7, 867-874. [LINK]
  • Liu, J.; Li, R. C.; Sand, G. J.; Bulmus, V.; Davis, T. P.; Maynard, H. D., "Keto-Functionalized Polymer Scaffolds as Versatile Precursors to Polymer Side Chain Conjugates," Macromolecules, 2013, 46, 8-14. [LINK]

2012

  • Vazquez-Dorbatt, V.; Lee, J.; Lin, E.-W.; Maynard, H. D., "Synthesis of Glycopolymers by Controlled Radical Polymerization Techniques and Their Applications," ChemBioChem, 2012, 13, 2478-2487. [LINK]
  • Grover, G. N.; Lam, J.; Nguyen, T. H.; Segura, T.; Maynard, H. D., "Biocompatible Hydrogels by Oxime Click Chemistry," Biomacromolecules, 2012, 13, 3013-3017. [LINK]
  • Kolodziej, C. M.; Maynard, H. D., "Shape-Shifting Micro and Nano-Patterns Controlled by Temperature," J. Am. Chem. Soc. 2012, 134, 12386-12389. [LINK]
  • Tolstyka, Z.; Maynard, H. D., "Protein-Polymer Conjugates," in Comprehensive Polymer Science, Edited by K. Matyjaszewski and M. Moller, Elsevier, 2012, vol 9, pp 317-337. [LINK]
  • Grover, G. N.; Lee, J.; Matsumoto, N. M.; Maynard, H. D., "Aminooxy and Pyridyl Disulfide Telechelic Poly(poly(ethylene glycol) acrylate) by RAFT Polymerization," Macromolecules, 2012, 45, 4958-4965. [LINK]
  • Mancini, R. J.; Lee, J.; Maynard, H. D., "Trehalose Glycopolymers for Stabilization of Protein Conjugates to Environmental Stressors," J. Am. Chem. Soc. 2012, 134, 8474-8479. [LINK]
  • Kolodziej, C. M.; Maynard, H. D., "Electron-Beam Lithography for Patterning Biomolecules at the Micron and Nanometer Scale," Chem. Mater. 2012, 24, 774-780. [LINK]
  • Kolodziej, C. M.; Kim, S. H.; Broyer, R. M.; Saxer, S. S.; Decker, C. G.; Maynard, H. D., "Combination of Integrin-Binding Peptide and Growth Factor Promotes Cell Adhesion on Electron-Beam Fabricated Patterns," J. Am. Chem. Soc. 2012, 134, 247-255. [LINK]

2011

  • Kim, S. H.; Nguyen, T. H.; Maynard, H. D., "Polymeric Drug Conjugates by Controlled Radical Polymerization," in Comprehensive Biomaterials, Edited by P. Ducheyne, K. Healy, D. Hutmacher, J. Kirkpatrick, Elsevier, 2011, vol 4, part 423, pp 377-388. [LINK]
  • Broyer, R. M.; Schopf, E.; Kolodziej, C. M.; Chen, Y.; Maynard, H. D., "Dual Click reactions to micropattern proteins," Soft Matter, 2011, 7, 9972-9977. [LINK]
  • Alconcel, S. N. S.; Baas, A. S.; Maynard, H. D., "FDA-Approved Poly(Ethylene Glycol)-Protein Conjugate Drugs," Polym. Chem. 2011, 2, 1442-1448. [LINK]
  • Gunasekaran, K.; Nguyen, T. H.; Maynard, H. D.; Davis, T. P.; Bulmus, V., "Conjugation of siRNA with Comb-Type PEG Enhances Serum Stability and Gene Silencing Efficiency,"Macromol. Rapid Commun. 2011, 32, 654-659. [LINK]
  • Christman, K. L.; Broyer, R. M.; Schopf, E.; Kolodziej, C. M.; Chen, Y.; Maynard, H. D., "Protein Nanopatterns by Oxime Bond Formation," Langmuir, 2011, 27, 1415-1418. [LINK]
  • Broyer, R. M.; Grover, G. N.; Maynard, H. D., "Emerging Synthetic Approaches for Protein-Polymer Conjugations," Chem. Commun. 2011, 47, 2212-2226. [LINK]
  • Kolodziej, C. M.; Chang, C. W.; Maynard, H. D., "Glutathion S-Transferase as a General and Reversible Tag for Surface Immobilization of Proteins," J. Mater. Chem. 2011, 21, 1457-1461.*[LINK]

2010

  • Grover, G. N.; Maynard, H. D., "Protein-Polymer Conjugates: Synthetic Approaches by CRP & Future Applications," Current Opin. Chem. Biol. 2010, 14, 818-827. [LINK]
  • Chang, C. W.; Nguyen, T. H.; Maynard, H. D., "Thermoprecipitation of Glutathion S-Transferase by Glutathion-Poly(N-isopropylacrylamide) Prepared by RAFT Polymerization,"Macromol. Rapid Commun. 2010, 31, 1691-1695.* [LINK]
  • Heredia, K. L.; Tao, L.; Grover, G. N.; Maynard, H. D., "Heterotelechelic Polymers for Capture and Release of Protein-Polymer Conjugates," Polym. Chem. 2010, 1, 168-170. [LINK]
  • Stuckel, J. M.; Li, R. C.; Maynard, H. D.; Caplan, M. R., "Two-step Synthesis of Multivalent Cancer-Targeting Constructs," Biomacromolecules, 2010, 11, 160-167. [LINK]
  • Garrell, R. G.; Maynard, H. D. "Surface Molecular Property Control" in Biomedical Technology: Applications to Microfluidics, Nano Optics and Surface Chemistry, Edited by C. M. Ho, Oxford University Press: Oxford, 2010, Chapter 11, 395-435.
  • Christman, K. L.; Maynard, H. D. "Surface Patterning for Generating Defined Nanoscale Matrices" in Methods in Molecular Biology: Stem Cells for Myocardial Repair and Regeneration, Edited by R. Lee, Humana Press, Inc., Totowa, NJ, 2010, vol. 660, part 6, 225-263. [LINK]

2009

  • Alconcel, S. N. S.; Grover, G. N.; Matsumoto, N. M.; Maynard, H. D., "Synthesis of Michael Acceptor Ionomers of Poly(4-Sulfonated Styrene-co-Poly(Ethylene Glycol) Methyl Ether Acrylate)," Aust. J. Chem. 2009, 62, 1496-1500. [LINK]
  • Vazquez-Dorbatt, V.; Tolstyka, Z. P.; Maynard, H. D., "Synthesis of Aminooxy End-functionalized pNIPAAm by RAFT Polymerization for Protein and Polysaccharide Conjugation,"Macromolecules, 2009, 42, 7650-7656. [LINK]
  • Grover, G. N.; Alconcel, S. N. S.; Matsumoto, N. M.; Maynard, H. D., "Synthesis of Thiol Terminated Acrylate Polymers with Divinyl Sulfone to Generate Well-Defined Semi-Telechelic Michael Acceptor Polymers," Macromolecules, 2009, 42 , 7657-7663. [LINK]
  • Mancini, R. J.; Li, R. C.; Tolstyka, Z. P.; Maynard, H. D., "Synthesis of a Photo-caged Aminooxy Alkane Thiol," Org. Biomol. Chem. 2009, 7, 4954-4959. [LINK]
  • Vazquez-Dorbatt, V.; Tolstyka, Z. P.; Chang, C. W.; Maynard, H. D., "Synthesis and Application of a Pyridyl Disulfide End-Functionalized Glycopolymer," Biomacromolecules, 2009, 10, 2207-2212. [LINK]
  • Tao, L.; Kaddis, C. S.; Ogorzalek Loo, R. R.; Grover, G. N.; Loo, J. A.; Maynard, H. D., "Synthesis of Maleimide-End Functionalized Star Polymers and Multimeric Protein-Polymer Conjugates," Macromolecules, 2009, 42, 8028-8033. [LINK]
  • Schopf, E.; Broyer, R. M.; Tao, L.; Chen, Y.; Maynard, H. D., "Directed Carbon Nanotube Assembly Using a Pyrene Functionalized Polymer," Chem. Commun. 2009, 4818-4820. [LINK]
  • Bays, E.; Tao, L.; Chang, C. W.; Maynard, H. D., "Synthesis of Semi-telechelic Maleimide Poly(PEGA) for Protein Conjugation by RAFT Polymerization," Biomacromolecules, 2009, 10, 1777-1781. [LINK]
  • Chang, C. W.; Bays, E.; Tao, L.; Alconcel, S. A.; Maynard, H. D., "Differences in Cytotoxicity of Poly(PEGA)s Synthesized by Reversible Addition-Fragmentation Chain Transfer Polymerization,"Chem. Commun. 2009, 3580-3582. [LINK]
  • Tao, L; Kaddis, C. S.; Ogorzalek Loo, R. R.; Grover, G.N.; Loo, J. A.; Maynard, H. D., "Synthetic Approach to Homodimeric Protein-Polymer Conjugates," Chem. Commun., 2009, 2148-2150. [LINK]
  • Heredia, K. L.; Grover, G. N.; Tao, L.; Maynard, H. D., "Synthesis of Heterotelechelic Polymers for Conjugation of Two Different Proteins," Macromolecules, 2009, 42, 2360-2367.*[LINK]
  • Christman, K. L.; Schopf, E.; Broyer, R. M.; Li, R. C.; Chen, Y.; Maynard, H. D., "Positioning Multiple Proteins at the Nanoscale with Electron Beam Cross-Linked Functional Polymers," J. Am. Chem. Soc. 2009, 131, 521-527. [LINK]
  • Maynard, H. D.; Broyer, R. M.; Kolodziej, C. M. "Protein and Peptide Conjugation to Polymers and Surfaces Using Oxime Chemistry," in Click Chemistry for Biotechnology and Materials Science, Edited by J. Lahann, Wiley Inc., West Sussex, UK, 2009, Chapter 4, 53-68.

2008

  • Christman, Wong, T. S.; Brough, B.; Christman, K. L.; Kolodziej, C. M.; Huang, A.; Lam, R.; Forbes, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M., "Manufacture of Nanoscale Structures through Top-down and Bottom-up Approaches," Proceedings of the IEEE 7th International Conference on Nanotechnology, 2008, 126-130.
  • Christman, K. L.; Vazquez-Dorbatt, V.; Schopf, E.; Kolodziej, C. M.; Li, R. C.; Broyer, R. M.; Chen, Y.; Maynard, H. D., "Nanoscale Growth Factor Patterns by Immobilization on a Heparin Mimicking Polymer," J. Am. Chem. Soc. 2008, 130, 16585-16591. [LINK]
  • Heredia, K. L.; Nguyen, T. H.; Chang, C. -W.; Bulmus, V.; Davis, T. P.; Maynard, H. D., "Reversible siRNA-Polymer Conjugates by RAFT Polymerization," Chem. Commun. 2008, 28, 3245-3247. [LINK]
  • Tolstyka, Z. P.; Kopping, J. T.; Maynard, H. D., "Straightforward Synthesis of Cysteine-Reactive Telechelic Polystyrene," Macromolecules, 2008, 41, 599-606. [LINK]
  • Broyer, R. M.; Quaker, G. M.; Maynard, H. D., "Designed Amino Acid ATRP Initiators for the Synthesis of Biohybrid Materials," J. Am. Chem. Soc., 2008, 130, 1041-1047. [LINK]

2007

  • Mendes, P. M.; Christman, K. L.; Parthasarathy, P.; Schopf, E.; Ouyang, J.; Yang, Y.; Preece, J. A.; Maynard, H. D.; Chen, Y.; Stoddart, J. F., "Electrochemically Controllable Conjugation of Proteins on Surfaces," Bioconjugate Chem. 2007, 18, 1919-1923. [LINK]
  • Kopping, J. T.; Tolstyka, Z. P.; Maynard, H. D., "Telechelic Aminooxy-Polystyrene Synthesized by ATRP and ATR Coupling," Macromolecules, 2007, 40, 8593-8599. [LINK]
  • Hwang, J.; Li, R. C.; Maynard, H. D., "Well-Defined Polymers with Activated Ester and Protected Aldehyde Side Chains for Bio-functionalization," J. Controlled Release, 2007, 122, 279-286. [LINK]
  • Maynard, H. D.; Heredia, K. L.; Li, R. C.; Parra, D. P.; Vazquez-Dorbatt, V., "Thermoresponsive Biohybrid Materials Synthesized by ATRP," J. Mater. Chem., 2007, 17, 4015-4017.* [LINK]
  • Li, R. C.; Hwang, J.; Maynard, H.D., "Reactive Block Copolymer Scaffolds," Chem. Commun. 2007, 3631-3633.* [LINK]
  • Heredia, K. L.; Tolstyka, Z. P.; Maynard, H. D., "Aminooxy End-Functionalized Polymers Synthesized by ATRP for Chemoselective Conjugation to Proteins," Macromolecules, 2007, 40, 4772-4779. [LINK]
  • Brough, B.; Christman, K. L.; Wong, T. S.; Kolodziej, C. M.; Forbest, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M, "Surface Initiated Actin Polymerization from Top-down Manufactured Nanopatterns," Soft Matter, 2007, 3, 541-546.* [LINK]
  • Christman, K. L.; Broyer, R. M.; Tolstyka, Z. P.; Maynard, H. D., "Site-Specific Protein Immobilization through N-Terminal Oxime Linkages," J. Mater. Chem. 2007, 17, 2021-2027.*[LINK]
  • Heredia, K. L.; Maynard, H. D., "Synthesis of Protein-Polymer Conjugates," Organic & Biomol. Chem. 2007, 5, 45-53.* [LINK]

2002-2006

  • Christman, K. L.; Enriquez-Rios, V. D.; Maynard, H. D., "Nanopatterning Proteins and Peptides," Soft Matter, 2006, 2, 928-939.* [LINK]
  • Christman, K. L.; Requa, M. V.; Enriquez-Rios, V. D.; Ward, S. C.; Bradley, K. A.; Turner, K. L.; Maynard, H. D., "Submicron Streptavidin Patterns for Protein Assembly," Langmuir, 2006, 22, 7444-7450. [LINK]
  • Li, R. C,; Broyer, R. M.; Maynard, H. D., "Well-Defined Polymers with Acetal Side Chains as Reactive Scaffolds Synthesized by Atom Transfer Radical Polymerization," J. Polym. Sci., Part A: Polym. Chem. 2006, 44, 5004-5013. [LINK]
  • Vazquez-Dorbatt, V.; Maynard H. D., "Biotinylated Glycopolymers Synthesized by Atom Transfer Radical Polymerization," Biomacromolecules, 2006, 7, 2297-2302. [LINK]
  • Heredia, K. L.; Bontempo, D.; Ly, T.; Byers, J. T.; Halstenberg, S.; Maynard, H. D.,"In-Situ Preparation of Protein-"Smart" Polymer Conjugates with Retention of Bioactivity, " J. Am. Chem. Soc. 2005, 127, 16955-16960. [LINK]
  • Bontempo, D.; Li, R. C.; Ly, T.; Brubaker, C. E.; Maynard, H. D., "One-Step Synthesis of Low Polydispersity, Biotinylated Poly(N-Isopropylacrylamide) by ATRP," Chem. Commun. 2005, 37, 4702-4704. [LINK]
  • Christman, K. L.; Maynard, H. D., "Protein Micropatterns Using a pH-Responsive Polymer and Light," Langmuir, 2005, 21, 8389-8393. [LINK]
  • Maynard, H. D.; Hubbell, J. A., "Discovery of a Sulfated Tetrapeptide that Binds to Vascular Endothelial Growth Factor" Acta Biomaterialia, 2005, 1, 451-459.
  • Bontempo, D.; Maynard, H. D.,"Streptavidin as a Macroinitiator for Polymerization: In Situ Protein-Polymer Conjugate Formation" J. Am. Chem. Soc. 2005, 127, 6508-6509. [LINK]
  • Bontempo, D.; Heredia, K. L.; Fish, B. A.; Maynard, H. D., "Cysteine-Reactive Polymers Synthesized by Atom Transfer Radical Polymerization for Conjugation to Proteins," J. Am. Chem. Soc. 2004, 126, 15372-15373. [LINK]

1989-2001

  • Maynard, H. D.; Lyu, S.; Fredrickson, G. H.; Wudl, F.; Chmelka, B. F., "Syntheses of Nanophase-Segregated Poly(vinyl acetate)-Poly(dimethylsiloxane) and Poly(vinyl acetate)-Poly(styrene) Graft Copolymers," Polymer, 2001, 42, 7567-7574. [LINK]
  • Maynard, H. D.; Okada, S. Y.; Grubbs, R. H., "Inhibition of Cell Adhesion to Fibronectin by Oligopeptide-Substituted Polynorbornenes," J. Am. Chem. Soc. 2001, 123, 1275-1279. [LINK]
  • Maynard, H. D.; Okada, S. Y.; Grubbs, R. H., "Synthesis of Norbornenyl Polymers With Bioactive Oligopeptides by Ring-Opening Metathesis Polymerization," Macromolecules, 2000, 33, 6239-6248. [LINK]
  • Maynard, H. D.; Grubbs, R. H., "Synthesis of Functionalized Polyethers by Ring-Opening Metathesis Polymerization of Unsaturated Crown Ethers," Macromolecules, 1999, 32, 6917-6924.[LINK]
  • Maynard, H. D.; Grubbs, R. H., "Purification Technique for the Removal of Ruthenium from Olefin Metathesis Reaction Products," Tetrahedron Lett. 1999, 40, 4137-4140. [LINK]
  • Williams, S. R.; Maynard, H. D.; Chmelka, B. F., "Synthesis of 13C-Enriched Pyrrole from 2-13C D-Galactose," J. Labelled Cpd. Radiopharm. 1999, 42, 927-936. [LINK]
  • Marsella, M. J.; Maynard, H. D.; Grubbs, R. H., "Template-Directed Ring-Closing Metathesis: Synthesis and Polymerization of Unsaturated Crown Ether Analogs," Angew. Chem. Int. Ed. Engl., 1997, 36, 1101-1103. [LINK]
  • Wagener, K. B.; Patton, J. T.; Forbes, M. D. E.; Myers, T. L.; Maynard, H. D., "Acyclic Diene Metathesis Polymerization: The Synthesis of Unsaturated Polyketones," Polym. Intern. 1993, 32, 411-415. [LINK]
  • Forbes, M. D. E.; Patton, J. T.; Myers, T. L.; Maynard, H. D.; Smith, D. W.; Schulz, G. R.; Wagener, K. B., "Solvent-Free Cyclization of Linear Dienes Using Olefin Metathesis and the Thorpe-Ingold Effect," J. Am. Chem. Soc. 1992, 114, 10978-10980. [LINK]
  • Forbes, M. D. E.; Myers, T. L.; Dukes, K. E.; Maynard, H. D., "Biradicals and Spin-Correlated Radical Pairs Anchored to SiO2 Surfaces: Probing Diffusion at the Solid/Solution Interface," J. Am. Chem. Soc. 1992, 114, 353-354. [LINK]
  • Forbes, M. D. E.; Dukes, K. E.; Myers, T. L.; Maynard, H. D.; Breivogel, C. S.; Jaspan, H. B., "Time-Resolved Electron Paramagnetic Resonance Spectroscopy of Organic Free Radicals Anchored to SiO2 Surfaces," J. Phys. Chem. 1991, 95, 10547-10549. [LINK]
  • Maynard, M. S.; Maynard, H. D., "HPLC Assay for Avermectin B1a and its Two Photoisomers Using a Photo Diode Array Detector," Bull. Environ. Contam. Toxicol. 1989, 43, 499-504. [LINK]