Deming, Timothy J.


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Division
Organic
Title
Faculty
Professor
Specialties
Organic
Materials

Contact Information

Email
Office
Engineering V 4121C
(310) 267-4450
Lab
Engineering V 4030 and 4031
(310) 204-5956

Short Biography

Timothy Deming received his B.S. in Chemistry fom the University of California, Irvine in 1989, and his Ph.D. in Chemistry from the University of California, Berkeley, in 1993. After a NIH postdoctoral fellowship at the University of Massachusetts, Amherst, he joined the faculty in the Materials Department at the University of California, Santa Barbara in 1995. Here he held a joint appointment in the Materials and Chemistry Departments where he was promoted to Associate Professor in 1999 and Full Professor in 2003. In 2004 he moved to UCLA as a Professor of Bioengineering and was also appointed as Professor of Chemistry and Biochemistry in 2005. He served as the Chair of the Department of Bioengineering from 2006-2011.

Biography

Timothy J. Deming received a B.S. in Chemistry fom the University of California, Irvine in 1989, and graduated with a Ph.D. in Chemistry from the University of California, Berkeley, under Bruce Novak in 1993. After a NIH postdoctoral fellowship at the University of Massachusetts, Amherst with David Tirrell, he joined the faculty in the Materials Department at the University of California, Santa Barbara in 1995. Here he held a joint appointment in the Materials and Chemistry Departments where he was promoted to Associate Professor in 1999 and Full Professor in 2003. His appointment is now as the Chair of the Bioengineering Department at the University of California, Los Angeles. Current research interests include polypeptide synthesis, self-assembly of block copolypeptides, and biological activity of polypeptides, for which he has received young investigator awards from the National Science Foundation, the Office of Naval Research, The Arnold and Mabel Beckman Foundation, the Alfred P. Sloan Foundation, the Camille and Henry Dreyfus Foundation, the Materials Research Society, and the IUPAC Macromolecular Division. He is a Fellow of the American Institute of Medical and Biological Engineering, and recently received the Fulbright-Tocqueville Distinguished Chair Award.

Research Interests

Research in the Deming group is focused on synthesis, processing, characterization and evaluation of biological and biomimetic materials based on polypeptides. These materials are being studied since they can be prepared from renewable resources, they can be biocompatible and biodegradable, and possess unique self-assembling properties. We utilize innovative chemistry techniques to synthesize materials with properties that rival the complexity found in biological systems. The polymers are then processed into ordered assemblies, which are characterized for both nanoscale structure as well as biological function. This interdisciplinary approach stimulates innovations and ideas which direct this research into new, exciting areas.

Honors & Awards

  • Initiative of Excellence Visiting Faculty Scholar, University of Bordeaux, France 2020.
  • Fulbright Scholar - Fulbright-Toqueville Distinguished Chair Award 2015-2016.
  • Professeur Invite, University of Bordeaux, France 2012.
  • Fellow of the American Institute for Medical and Biological Engineering (AIMBE) 2010.
  • Herbert Newby McCoy Award (UCLA Dept. of Chem. & Biochem.) 2008.
  • IUPAC Macromolecular Division, Samsung-IUPAC Young Scientist Award 2004.
  • Materials Research Society Young Investigator Award 2003.
  • Rothschild and Mayent Foundation Fellow, Institut Curie, Paris 2002.
  • Camille Dreyfus Teacher-Scholar Award 2000
  • 3M Non-Tenured Faculty Award 1999
  • Beckman Young Investigator Award 1998
  • Alfred P. Sloan Research Fellow 1998
  • National Science Foundation CAREER Award 1997
  • Office of Naval Research Young Investigator 1996.
  • University of California, Regents Junior Faculty Fellow 1996
  • Unilever Award for Outstanding Graduate Research in Polymer Chemistry 1994.
  • NIH National Reseach Service Award Postdoctoral Fellow 1993 - 1995

Publications

173) “Modification of poly(5,6-epoxy-L-norleucine) gives functional polypeptides with alternative side-chain linkages”. Perlin, P.; Scott, W. A.; Deming, T. J. Biomacromolecules202021, 126-132. online 9-4-19. DOI: 10.1021/acs.biomac.9b01065 Special issue: “Future of Biomacromolecules at a Crossroad of Polymer Science and Biology”

 

172) “Self-sorting microscale compartmentalized block copolypeptide hydrogels.” Sun, Y.; Bentolila, L. A.; Deming, T. J. ACS Macro Lett., 20198, 1275-1279. online 9-14-19. DOI: 10.1021/acsmacrolett.9b00669

 

171) “Tunable, functional diblock copolypeptide hydrogels based on methionine homologs”. Negri, G. E.; Gharakhanian, E. G.; Deming, T. J. Macromolecular Biosci., 201919, 1900243 (7 pages) online 9-4-19. DOI: 10.1002/mabi.201900243 Special issue: "20 Years of Macromolecular Bioscience".

 

170) “Influence of sulfoxide group placement on polypeptide conformational stability”. Gharakhanian, E. G.; Bahrun, E.; Deming, T. J. J. Amer. Chem. Soc., 2019141, 14530-14533. online 9-1-19. DOI: 10.1021/jacs.9b07223

 

169) “Human vault nanoparticle targeted delivery of antiretroviral drugs to inhibit human immunodeficiency virus type 1 infection.” Fulcher, J. A.; Tamshen, K.; Wollenberg, A. L.; Kickhoefer, V. A.; Mrazek, J.; Elliott, J.; Ibarrondo, F. J.; Anton, P. A.; Rome, L. H.; Maynard, H. D.; Deming, T. J.; Yang, O. O. Bioconjugate Chem., 201930, 2216-2227. DOI: 10.1021/acs.bioconjchem.9b00451

 

168) “Self-healing multiblock copolypeptide hydrogels via polyion complexation.” Sun, Y.; Deming, T. J. ACS Macro Lett., 20198, 553-557. online 4-30-19. DOI: 10.1021/acsmacrolett.9b00269

 

167) “Versatile N-methylaminooxy functionalized polypeptides for preparation of neoglycoconjugates”. Wollenberg, A. L.; Perlin, P.; Deming, T. J. Biomacromolecules201920, 1756-1764. online 3-15-19. DOI: 10.1021/acs.biomac.9b00138

 

166) “Future directions at the frontier of polymer science and biology”. Lecommandoux, S.; Klok, H. A.; Zhong, Z.; Deming, T. J. Biomacromolecules, 2019, 20, 1-3.

 

165) "Required growth facilitators propel axon regeneration across complete spinal cord injury”. Anderson, M. A.; O’Shea, T. M.; Burda, J. E.; Ao, Y.; Barlatey, S. L.; Bernstein, A. M.; Kim, J. H.; James, N. D.; Rogers, A.; Kato, B.; Wollenberg, A. L.; Kawaguchi, R.; Coppola, G.; Wang, C.; Deming, T. J.; He, Z.; Courtine, G.; Sofroniew, M. V. Nature, 2018, 561, 369-400.

 

164) “Influence of sulfur containing di-amino acid structure on covalently crosslinked copolypeptide hydrogels”. Raftery, E. D.; Gharakhanian, E. G.; Ricapito, N. G.; McNamara, J.; Deming, T. J. Chem. Asian J., 2018, 13, 3547-3553.

 

163) “Polymers at the interface with biology”. Deming, T. J.; Klok, H. A.; Armes, S. P.; Becker, M. L.; Champion J. A.; Chen, E. Y.; Heilshorn, S. C.; van Hest, J. C. M.; Irvine, D. J.; Johnson, J. A.; Kiessling, L. L.; Maynard, H. D.; de la Cruz, M. O.; Sullivan, M. O.; Tirrell, M. V.; Anseth, K. S.; Lecommandoux, S.; Percec, S.; Zhong, Z.; Albertsson, A. C. Biomacromolecules, 2018, 19, 3151-3162.

 

162) Homoallylglycine residues are superior precursors to orthogonally modified thioether containing polypeptides”. Perlin, P.; Gharakhanian, E. G.; Deming, T. J. Chem. Commun., 2018, 54, 6196 - 6199.

 

161) “Polypeptide gels incorporating the exotic functional aromatic amino acid 4-amino-L-phenylalanine”. Kaneko, T.; Ali, M.; Captain, I.; Perlin, P.; Deming, T. J. Polym. Chem., 2018, 9, 3466-3472.

 

160) “Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery”. Wollenberg, A. L.; O’Shea, T. M.; Kim, J. H.; Czechanski, A.; Reinholdt, L. G.; Sofroniew, M. V.; Deming, T. J. Biomaterials, 2018, 178, 527-545.

 

159) “Conformation directed formation of self-healing diblock copolypeptide hydrogels via polyion complexation”. Sun, Y.; Wollenberg, A. L.; O’Shea, T. M.; Cui, Y.; Zhou, Z. H.; Sofroniew, M. V.; Deming, T. J. J. Amer. Chem. Soc., 2017, 139, 15114–15121.

 

158) “The use of TMZ embedded hydrogels for the treatment of orthotopic human glioma xenografts.” Adhikari, B.; Li, J.; Brandel, M. G.; Futalan, D.; Akers, J.; Deming, T. J.; Chen, C. C.; Carter, B. S. J. Clin. Neurosci.,2017, 45, 288-292.

 

157) "Tuning thermoresponsive properties of cationic elastin-like polypeptides by varying counterions and side-chains". Petitdemange, R.; Garanger, E.; Bataille, L.; Bathany, K.; Garbay, B.; Deming, T. J.; Lecommandoux, S. Bioconjugate Chem., 2017, 28, 1403–1412.

 

156) “Development of hybrid diblock copolypeptide amphiphile/magnetic metal complexes and their spin crossover with low-critical-solution temperature (LCST)-type transition.” Tsubasa, A.; Outsuka, S.; Maekawa, T.; Takano, R.; Sakurai, S., Deming, T. J.; Kuroiwa, K. Polymer, 2017, 128, 347-355.

 

155) “Amino Acid Block Copolymers with Broad Antimicrobial Activity and Barrier Properties”. Bevilacqua, M. P.; Huang, D. J.; Wall, B. D.; Lane, S. J.; Edwards III, C. K.; Hanson, J. A.; Benitez, D.; Solomkin, J. S.; Deming, T. J. Macromolecular Biosci., 2017, 17, 1600492 (9 pages)

 

154) “Functional modification of thioether groups in peptides, polypeptides, and proteins”. Deming, T. J. Bioconjugate Chem., 2017, 28, 691−700

 

153) "Selective tuning of elastin-like polypeptide properties via methionine oxidation". Petitdemange, R.; Garanger, E.; Bataille, L.; Dieryck, W.; Bathany, K.; Garbay, B.; Deming, T. J.; Lecommandoux, S. Biomacromolecules, 2017, 18, 544-550.

 

152) “Protein complexation and pH dependent release using boronic acid containing PEG-polypeptide copolymers”. Negri, G. N.; Deming, T. J. Macromolecular Biosci., 2017, 17, 160013 (6 pages).

 

151) “Smart materials for Central Nervous System Cell Delivery and Tissue Engineering”. O’Shea, T. M.; Wollenberg, A. L.; Bernstein, A. M.; Sarte, D. B.; Deming, T. J.; Sofroniew, M. V. Chapter 19 in Smart Materials for Tissue Engineering: Applications (Smart Materials Series #25), Wang, Q. (ed.), RSC, 2017, p.529-557.

 

150) “Polypeptide-Based Gold Nanoshells for Photothermal Therapy”. Mayle, K. M.; Dern, K. R.; Wong, V. K.; Sung, S.; Ding, K.; Rodriguez, A. R.; Taylor, Z.; Zhou, H.; Grundfest, W. S.; Deming, T. J.; Kamei, D. T. J. Lab. Autom., 2017, 22, 18-25.

 

149) “Engineering A11 minibody-conjugated, polypeptide-based gold nanoshells for prostate stem cell antigen (PSCA)-targeted photothermal therapy”. Mayle, K. M.; Dern, K. R.; Wong, V. K.; Chen, K. Y.; Sung, S.; Ding, K.; Rodriguez, A. R.; Knowles, S.; Taylor, Z.; Zhou, H.; Grundfest, W. S.; Wu, A. M.; Deming, T. J.; Kamei, D. T. J. Lab. Autom., 2017, 22, 26-35. 

 

148) “Methionine sulfoxide and phosphonate containing double hydrophilic block copolypeptides and their mineralization of calcium carbonate”. Captain, I.; Deming, T. J. J. Poly. Sci. Part A: Poly. Chem. 2016, 54, 3707–3712.

 

147) “Triggered copolypeptide hydrogel degradation using photolabile lysine protecting groups”. Negri, G. N.; Deming, T. J. ACS Macro Lett., 2016, 5, 1253-1256.

 

146) “Role of side-chain molecular features in tuning lower critical solution temperatures (LCSTs) of oligoethylene glycol modified polypeptides”. Gharakhanian, E. G.; Deming, T. J. J. Phys. Chem. B, 2016, 120, 6096-6101.

 

145) “Chemoselective synthesis of functional homocysteine residues in polypeptides and peptides”. Gharakhanian, E. G.; Deming, T. J. Chem. Commun., 2016, 52, 5336-5339.

 

144)“Astrocyte scar formation aids CNS axon regeneration”. Anderson, M. A.; Burda, J. E.; Ren, Y.; Ao, Y.; O’Shea, T. M.; Kawaguchi, R.; Coppola, G.; Khakh, B. S.; Deming, T. J.; Sofroniew, M. V. Nature, 2016, 532, 195-200.

 

143) “Synthesis of side-chain modified polypeptides”. Deming, T. J. Chem. Rev. 2016, 116, 786–808.

 

142) “Use of methionine alkylation to prepare cationic and zwitterionic block copolypeptide vesicles”. Rodriguez, A. R.; Choe, U-J.; Kamei, D. T.; Deming, T. J. Israel J. Chem., 2016, 56, 607-613.

 

141) "Artificial membranes composed of synthetic copolypeptides". Deming, T. J. in Handbook of Lipid Membranes: Molecular, Functional, and Materials Aspects, Safinya, C. R. and R�dler, J. (eds.), Taylor and Francis, in press

 

140) “The targeted delivery of doxorubicin with transferrin-conjugated block copolypeptide vesicles”. Lee, B. S.; Yip, A. T.; Thach, A. V.; Rodriguez, A. R.; Deming, T. J.; Kamei, D. T. Int. J. Pharmaceut. 2015, 496, 903-911.

 

139) "Quantitative side-chain modifications of methionine-containing elastin-like polypeptides as a versatile tool to tune their properties". Kramer, J. R.; Petitdemange, R.; Bataille, L.; Bathany, K.; Wirotius, A.-L.; Garbay, B.; Deming, T. J.; Garanger, E.; Lecommandoux, S. ACS Macro Lett., 2015, 4, 1283-1286.

 

138) “Thermoresponsive copolypeptide hydrogel vehicles for CNS cell delivery”. Zhang, S.; Burda, J. E.; Anderson, M. A.; Zhao, Z.; Ao, Y.; Cheng, Y.; Sun, Y.; Deming, T. J.; Sofroniew, M. V. ACS Biomater. Sci. Eng., 2015, 705-717.

 

137) “Versatile synthesis of stable, functional polypeptides via reaction with epoxides”. Gharakhanian, E. G.; Deming, T. J. Biomacromolecules, 2015, 16, 1802-1806.

 

136) “Supramolecular control of reverse spin transitions in cobalt(II) terpyridine complexes with diblock copolypeptide amphiphiles”. Kuroiwa, K.; Arie, T.; Sakurai, S.; Hayami, S.; Deming, T. J.; J. Mater. Chem. C, 2015, 3, 7779-7783

 

135) “Controlled synthesis of phosphorylcholine derivatives of poly(serine) and poly(homoserine)”. Yakovlev, I.; Deming, T. J. J. Amer. Chem. Soc., 2015, 137, 4078-4081.

 

134) “Reinventing cell penetrating peptides using glycosylated methionine sulfonium ion sequences”. Kramer, J. R.; Schmidt, N. W.; Mayle, K. M.; Kamei, D. T.; Wong, G. C. L.; Deming, T. J. ACS Central Sci., 2015, 1, 83-88.

 

133) “Design and synthesis of non-ionic copolypeptide hydrogels with reversible thermoresponsive and tunable physical properties”. Zhang, S.; Alvarez, D. J.; Sofroniew, M. V.; Deming, T. J. Biomacromolecules, 2015, 16, 1331-1340

 

132) “Biodegradable containers composed of anionic liposomes and cationic polypeptide vesicles”. Yaroslavov, A. A.; Zaborova, O. V.; Sybachin, A. V.; Kalashnikova, I. V.; Rodriguez, A. R.; Deming, T. J. RSC Adv. 2015, 5, 98687–98691.

 

131) “Blending of diblock and triblock copolypeptide amphiphiles yields cell penetrating vesicles with low toxicity”. Rodriguez, A. R.; Choe, U-J.; Kamei, D. T.; Deming, T. J. Macromolecular Biosci., 2015, 15, 90-97.

 

130) “Analogues of Poly(l-phosphoserine) via Living Polymerization of Phosphonate-Containing N-Carboxyanhydride Monomers”. Yakovlev, I.; Deming, T. J. ACS Macro Lett., 2014, 3, 378-381.

 

129) “Multimodal switching of conformation and solubility in homocysteine derived polypeptides”. Kramer, J. R.; Deming, T. J. J. Amer. Chem. Soc., 2014, 136, 5547–5550.

 

128) “Preparation and development of block copolypeptide vesicles and hydrogels for biological and medical applications”. Deming, T. J. WIREs Nanomed. Nanobiotechnol., 2014, 6, 283-297.

 

127) “Synthesis and self-assembly of well defined block copolypeptides via controlled NCA polymerization”. Deming, T. J. in “Hierarchical Macromolecular Structures: 60 Years after the Staudinger Nobel Prize II”, Percec, V. (Ed.), Adv. Polymer Sci., 2013, 262, 1-37.

 

126) “Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system”. Zhang, S.; Anderson, M. A.; Ao, Y.; Khakh, B. S.; Deming, T. J.; Sofroniew, M. V. Biomaterials, 2014, 35, 1989-2000.

 

125) "Recent advances in glycopolypeptide synthesis". Kramer, J. R.; Deming, T. J. Polym. Chem., 2014, 5, 671-682.

 

124) “Enzyme-triggered cargo release from readily prepared copolypeptide vesicles”. Rodriguez, A. R.; Kramer, J. R.; Deming, T. J. Biomacromolecules, 2013, 14, 3610-3614.

 

123) “Soluble, clickable polypeptides from azide containing NCA monomers”. Rhodes, A. J.; Deming, T. J. ACS Macro Lett., 2013, 2, 351-354.

 

122) “Reversible chemoselective tagging and functionalization of methionine containing peptides”. Kramer, J. R.; Deming, T. J. Chem. Commun., 2013, 49, 5144 - 5146.

 

121) “Self-assembly of Discrete Metal Complexes in Aqueous Solution via Block Copolypeptide Amphiphiles”. Kuroiwa, K.; Masaki, Y.; Koga, Y.; Deming, T. J.; Int. J. Molecular Sci., 2013, 14, 2022- 2035.

 

120) “Endocytosis and Intracellular Trafficking Properties of Transferrin-Conjugated Block Copolypeptide Vesicles”. Choe, U-J.; Rodriguez, A. R.; Lee, B. S.; Knowles, S.; Wu, A. M.; Deming, T. J.; Kamei, D. T. Biomacromolecules, 2013, 14, 1458-1464.

 

119) “Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology”. Kramer, J. R.; Rodriguez, A. R.; Choe, U-J.; Kamei, D. T.; Deming, T. J. Soft Matter, 2013, 9, 3389-3395.

 

118) "Characterization of minimization of block copolypeptide Vesicle toxicity using different Hydrophobic Chain Lengths". Choe, U-J.; Rodriguez, A. R.; Li, Z.; Boyarskiy, S.; Deming, T. J.; Kamei, D. T. Macromolecular Chem. Phys., 2013, 214, 994-999.

 

117) "Transfection of mammalian cells using block copolypeptide vesicles". Sun, V.Z.; Choe, U-J.; Rodriguez, A.R.; Deming, T.J.; Kamei, D.T. Macromolecular Biosci., 2013, 13, 539-550.

 

116) "Engineering Polypeptide Coatings to Augment Gene Transduction and in vivo Stability of Adenoviruses". Jiang, Z.K.; Koh, S.B.S; Sato, M.; Atanasov, I.C.; Johnson, M.; Zhou, Z.H.; Deming, T.J.; Wu, L.J. Controlled Rel., 2013, 166, 75-85.

 

115) "Tandem Catalysis for the Preparation of Cylindrical Polypeptide Brushes". Rhodes, A.J.; Deming, T.J. Amer. Chem. Soc., 2012, 134, 19463-19467.

 

114) "Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypepetide hydrogel depots". Song, B.; Song, J.; Zhang, S.; Anderson, M. A.; Ao, Y.; Yang, C-Y.; Deming T.J.; Sofroniew, M.V. Biomaterials, 2012, 33 9105-9116

 

113) “Preparation of Multifunctional and Multireactive Polypeptides via Methionine Alkylation”. Kramer, J. R.; Deming, T. J. Biomacromolecules, 2012, 13, 1719-1723.

 

112) “Glycopolypeptides with a redox triggered helix to coil transition”. Kramer, J. R.; Deming, T. J. J. Amer. Chem. Soc., 2012, 134, 4112-4115.

 

111) “Fine Tuning of Vesicle Assembly and Properties Using Dual Hydrophilic Triblock Copolypeptides”. Rodriguez, A. R.; Choe, U-J.; Kamei, D. T.; Deming, T. J. Macromolecular Biosci., 2012, 12, 805-811.

 

110) "Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides". Deming, T. J. in Polymer Science: A Comprehensive Reference, Matyjaszewski, K. and M�ller, M. (eds.),Elsevier BV, 2012, 4, 427-429.

 

109) “Peptide-Based Materials”. Deming, T. J. (Ed.) Top. Curr. Chem., 2012, 310, 1 – 171.

 

108) “Synthesis of Polypeptides by Ring-Opening Polymerization of a-Amino Acid N-Carboxyanhydrides”. Cheng, J.; Deming, T. J. Top. Curr. Chem., 2012, 310, 1 – 26.

 

107) “Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions”. Mishra, A.; Lai, G. H.; Schmidt, N. W.; Sun, V. Z.; Rodriguez, A. R.; Tong, R.; Tang, L.; Cheng, J. J.; Deming, T. J.; Kamei, D. T.; Wong, G. C. L. Proc. Natl. Acad. Sci. (USA), 2011, 108, 16883-16888.

 

106) "Functionalized nanoscale through microscale polypeptide stabilized emulsions for display of biomolecules". Hanson, J. A.; Deming, T. J. Polym. Chem., 2011, 2, 1473 - 1475.

 

105) “A general method for purification of a-amino acid-N-carboxyanhydrides using flash chromatography”. Kramer, J. R.; Deming, T. J. Biomacromolecules, 2010, 11, 3668 - 3672.

 

104) “Glycopolypeptides via Living Polymerization of Glycosylated-L-lysine N-Carboxyanhydrides.” Kramer, J. R.; Deming, T.J. J. Am. Chem. Soc. 2010, 132 (42), 15068-15071.

 

103) “Intracellular Fates of Cell Penetrating Block Copolypeptide Vesicles”. Sun, V. Z.; Li, Z.; Deming, T. J.; Kamei, D. T. Biomacromolecules, 2011, 12, 10-13.

 

102) “Nonionic Block Copolypeptide Micelles Containing a Hydrophobic rac-Leucine Core.” Hanson, J. A.; Li, Z.; Deming, T.J. Macromolecules. 2010, 43, 6268-6269.

 

101) “Engineering Polypeptide Coatings to Modify Adenoviruses for Gene Therapy”. Koh, S. B. S.; Atanasov, I. C.; Johnson, Mai; Zhou, Z. H.; Deming, T. J.; Wu, L. J. Controlled Rel., 2012, submitted.

 

100) “Regenerative Medicine: Noodle Gels For Cells.” Deming, T. J. Nature Materials. 2010, 9, 535-536.

 

99) “Tunable Hydrogel Morphology Via Self-Assembly of Amphiphilic Pentablock Copolypeptides.” Li, Z.B.; Deming, T.J. Soft Matter. 2010, 6, 2546-2551.

 

98) “Synthesis and Cross Linking of L-DOPA Containing Polypeptide Vesicles.” Holowka, E. P.; Deming, T.J. Macromolecular Bioscience, 2010, 10, 496-502.

 

97) "Self-assembled Calcium Phosphate Nanocomposites Using Block Copolypeptide Templates.” Hu, Y.; Yusufoglu, Y.; Kanapathipillai, M.; Yang, C.Y.; Wu, Y.Q.; Thiyagarajan, P.; Deming, T.; Akinc, M.; Schmidt-Rohr, K.; Mallapragada, S. Soft Matter, 2009, 5, 4311-4320.

 

96) “Biocompatibility of Amphiphilic Diblock Copolypeptide Hydrogels in the Central Nervous System”. Yang, C.-Y.; Song, B.; Ao, Y.; Nowak, A. P.; Abelowitz, R. B.; Korsak, R. A.; Havton L. A.; Deming, T. J.; Sofroniew, M. V. Biomaterials, 2009, 30, 2881-2898.

 

95) "Triggered Release of siRNA from Poly(ethylene glycol)-protected, pH-dependent Liposomes" Auguste, D.T.; Furman, K.; Wong, A.; Fuller, J.; Armes, S.R.; Deming, T.J.; Langer, R. Journal of Controlled Release, 2008, 130, 266-274.

 

94) "Nanoscale Double Emulsions Stabilized by Single Component Block Copolypeptides" Hanson, J.A.; Chang, C.; Graves, S.; Li, Z.; Mason, T.G.; and Deming, T.J. Nature, 2008, 455, 85-88.

 

93) “Methods and Compositions for controlled polypeptide synthesis”. Deming, T. J. U. S. Patent # 7,329,727. Issued 2/12/2008.

 

92) "Synthetic Polypeptides for Biomedical Applications" Deming, T.J. Progress in Polymer Science, 2007, 32, 858-875.

 

91) “Polyarginine Segments in Block Copolypeptides Drive Both Vesicular Assembly and Intracellular Delivery” Holowka, E. P.; Sun, V. Z.; Kamei, D. T.; Deming, T. J. Nature Materials, 2007, 6, 52–57.

 

90) “Macromolecular Engineering of Polypeptides Using the Ring Opening Polymerization of alpha-amino acid-N-carboxyanhydrides” Klok, H-A.; Deming, T.J. in Macromolecular Engineering, Gnanou, Y.; Matyjaszewski, K. and Leibler, L. Eds., Wiley, New York, 2007, 1, 519-540.

 

89) “Hydrogel Formation in Amphiphilic Triblock Copolypeptides” Nowak, A. P.; Sato, J.; Breedveld, V.; Deming, T. J. Supramolecular Chemistry, 2006, 18, 423-427.

 

88) “Thermotropic Polypeptides Bearing Side-On Mesogens” Schaefer, K. E.; Keller, P.; Deming, T. J. Macromolecules , 2006, 39, 19-22.

 

87) “pH triggered release of protective poly(ethyleneglycol)-b-polycation copolymers from liposomes” Auguste, D. T.; Armes, S. P.; Brzezinska, K. B.; Deming, T. J.; Kohn, J.; Prud’homme, R. K. Biomaterials, 2006, 27, 2599-2608.

 

86) “Monoliths of Aligned Silica-Polypeptide Hexagonal Platelets” Bellomo, E. G.; Deming, T. J. J. Am. Chem. Soc. , 2006, 128, 2276-2279.

 

85) “Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization” Deming, T. J. Advances in Polymer Science: Peptide Hybrid Polymers, 2006, 202, 1-18.

 

84) “Charged Polypeptide Vesicles with Controllable Diameter” Holowka, E. P.; Pochan, D. J.; Deming, T. J. J. Am. Chem. Soc. , 2005, 127, 12423 - 12428.

 

83) “Polypeptide Templated Synthesis of Hexagonal Platelets” Tomczak, M. M.; Glawe, D. D.; Drummy, L. F.; Lawrence, C. G.; Stone, M. O.; Perry, C. C.; Pochan, D. J.; Deming, T. J.; Naik, R. R. J. Am. Chem. Soc. , 2005, 127, 12577 - 12582.

 

82) “Preparation and Characterization of Synthetic Polypeptide Single Crystals with Controlled Thickness” Cui, H.; Krikorian, V.; Thompson, J.; Nowak, A. P.; Deming, T. J.; Pochan, D. J. Macromolecules , 2005, 38, 7371-7377.

 

81) “Polypeptide Hydrogels via a Unique Assembly Mechanism” Deming, T. J. Soft Matter, 2005, 1, 28-35.

 

80) “Transition metal initiators for controlled poly (beta-peptide) synthesis from beta-lactam monomers”. Deming, T. J.; Cheng, J. U. S. Patent # 6818732. Issued 11/16/2004.

 

79) “Micrometer-Sized Spherical Assemblies of Polypeptides and Small Molecules by Acid-Base Chemistry” McKenna, B. J.; Birkedal, H.; Bartl, M. H.; Deming, T. J.; Stucky, G. D. Angew. Chem. Int. Ed., 2004, 43, 5652-5655.

 

78) “Design of a doubly-hydrophilic block copolypeptide that directs the formation of calcium carbonate microspheres” Euliss, L. E.; Trnka, T. M.; Deming, T. J.; Stucky, G. D. Chem. Comm., 2004, 1736-1737.

 

77) “Methods and Compositions for controlled polypeptide synthesis”. Deming, T. J.; Seidel, S. W. U. S. Patent # 6,686,446. Issued 2/3/2004.

 

76) “Aqueous Cholesteric Liquid Crystals Using Uncharged Rod-Like Polypeptides” Bellomo, E. G.; Davidson, P.; Imp�ror-Clerc, M.; Deming, T. J. J. Am. Chem. Soc. 2004, 126, 9101-9105.

 

75) “Synthesis of AB Diblock Copolymers via Controlled/”living” Radical Polymerization (ATRP) and Living Polymerization of alpha-Amino Acid-N-Carboxyanhydrides” Brzezinska, K. R.; Deming, T. J. Macromolecular Biosci. 2004, 4, 566-569.

 

74) “Rod–rod and rod–coil self-assembly and phase behavior of polypeptide diblock copolymers” Minich, E. A.; Nowak, A. P.; Deming, T. J.; Pochan, D. J. Polymer 2004, 45, 1951-1957.

 

73) “Rheology of Block Copolypeptide Solutions: Hydrogels with Tunable Properties”. Breedveld, V.; Nowak, A. P.; Sato, J.; Deming, T. J.; Pine, D. J. Macromolecules , 2004, 37, 3943-3953.

 

72) “Stimuli Responsive Polypeptide Vesicles via Conformation Specific Assembly” Bellomo, E.; Wyrsta, M. D.; Pakstis, L.; Pochan, D. J.; Deming, T. J. Nature Materials, 2004, 3, 244-248.

 

71) “Effect of Chemistry and Morphology on the Biofunctionality of Self-Assembling Diblock Copolypeptide Hydrogels”. Pakstis, L.; Ozbas, B.; Nowak, A. P.; Deming, T. J.; Pochan, D. J. Biomacromolecules 2004, 5, 312-318.

 

70) “Methods and Compositions for controlled polypeptide synthesis”. Deming, T. J. U. S. Patent # 6,680,365. Issued 1/20/2004.

 

69) “Cooperative Assembly of Magnetic Nanoparticles and Block Copolypeptides in Aqueous Media” Euliss, L. E.; Grancharov, S. G.; O’Brien, S.; Deming, T. J.; Stucky, G. D.; Murray, C. B.; Held, G. A. Nano Lett., 2003, 3, 1489-1493.

 

68) “Unusual Salt Stability in Highly Charged Diblock Copolypeptide Hydrogels”. Nowak, A. P.; Breedveld, V.; Pine, D. J.; Deming, T. J. J. Amer. Chem. Soc. 2003, 125, 15666-15670.

 

67) “Methods, compositions, and biomimetic catalysts for in vitro synthesis of silica, polysilsequioxane, polysiloxane, and polymetallo-oxanes”. Morse, D. E.; Stucky, G. D.; Deming, T. J.; Cha, J.; Shimizu, K.; Zhou, Y. U. S. Patent # 6,670,438. Issued 12/30/2003.

 

66) “Microcavity Lasing from Block Peptide Hierarchically Assembled Quantum Dot Spherical Resonators”. Cha, J. N.; Bartl, M. H.; Wong, M. S.; Popitsch, A.; Deming, T. J.; Stucky, G. D. Nano Lett., 2003, 3, 907-911.

 

65) “Methods and Compositions for controlled polypeptide synthesis”. Deming, T. J.; Curtin, S. A. U. S. Patent # 6,632,922. Issued 10/14/2003.

 

64) “Spontaneous Formation of Nanoparticle Vesicles from Homopolymer Polyelectrolytes”. Cha, J. N.; Birkedal, H.; Euliss, L. E.; Bartl, M. H.; Wong, M. S.; Deming, T. J.; Stucky, G. D. J. Am. Chem. Soc. , 2003, 125, 8285-8289.

 

63) “Synthesis and crosslinking of catechol containing copolypeptides”. U. S. Patent # 6,506,577. Issued 1/14/2003.

 

62) “Polypeptide-based Nanocomposite: Structure and Properties of Poly(L-lysine)/Na+-montmorillonite”. Krikorian, V.; Kurian, M.; Galvin, M. E.; Nowak, A. P.; Deming, T. J.; Pochan, D. J. Polymer Sci. Polym. Phys, 2002, 40, 2579-2586.

 

61) “Use of Chiral Ruthenium and Iridium Amido-Sulfonamidate Complexes for Controlled, Enantioselective Polypeptide Synthesis”. Seidel, S. W.; Deming, T. J. Macromolecules , 2003, 36, 969-972.

 

60) “Modular, energy-dissipating material and method for using it”. Hansma, P. K.; Kindt, J.; Deming, T. J.; Morse, D. E.; Stucky, G. D. U. S. Patent # 6,376,636. Issued 4/23/2002.

 

59) “Methodologies for preparation of synthetic block copolypeptides: materials with future promise in drug delivery”. Deming, T. J. Adv. Drug Deliv. Rev., 2002, 54, 1145-1155.

 

58) “SANS and Cryo-TEM Study of Self-Assembled Diblock Copolypeptide Hydrogels with Rich Nano- through Microscale Morphology”. Pochan, D. J.; Pakstis, L.; Ozbas, B.; Nowak, A. P.; Deming, T. J. Macromolecules , 2002, 35, 5358-5360.

 

57) “Assembly of Nanoparticles into Hollow Spheres Using Block Copolypeptides”. Wong, M. S.; Cha, J. N.; Choi, K-S.; Deming, T. J.; Stucky, G. D. Nano Lett., 2002, 2, 583-587.

 

56) “Polypeptide End-capping Using Functionalized Isocyanates: Preparation of Pentablock Copolymers”. Brzezinska, K. R.; Curtin, S. A.; Deming, T. J. Macromolecules , 2002, 35, 2970-2976.

 

55) “Rapidly Recovering Hydrogel Scaffolds From Self-Assembling Diblock Copolypeptide Amphiphiles”. Nowak, A. P.; Breedveld, V.; Pakstis, L.; Ozbas, B.; Pine, D. J.; Pochan, D.; Deming, T. J. Nature , 2002, 417, 424-428.

 

54) “A Parallel Synthetic Approach for the Analysis of Membrane Interactive Copolypeptides”. Wyrsta, M. D.; Cogen, A. L.; Deming, T. J. J. Am. Chem. Soc. , 2001, 123, 12919-12920.

 

53) “Controlled Polymerization of β-Lactams Using Metal-Amido Complexes. Synthesis of Block Copoly(beta-Peptides)”. Cheng, J.; Deming, T. J. J. Am. Chem. Soc. , 2001, 123, 9457-9458.

 

52) “Synthesis and Conformational Analysis of Optically Active Poly(β-peptides)”. Cheng, J.; Deming, T. J. Macromolecules , 2001, 34, 5169-5174.

 

51) “Synthesis of ABA Triblock Copolymers via Acyclic Diene Metathesis Polymerization and Living Polymerization of alpha-Amino Acid-N-Carboxyanhydrides”. Brzezinska, K. R.; Deming, T. J. Macromolecules , 2001, 34, 4348-4354.

 

50) "Methylated Mono and Diethyleneglycol-Functionalized Beta-Sheet Forming Polypeptides". Hwang, J. and Deming, T. J. Biomacromolecules , 2001, 2, 17-21.

 

49) “Polymerization of Amino Acid Derivatives”. Deming, T. J. in Encyclopedia of Materials: Science and Technology, Kramer, E. J. Ed., Pergamon, Oxford (2001).

 

48) "Living Polymerization of Alpha-Amino Acid-N-Carboxyanhydrides". Deming, T. J. J. Polym. Sci. Polym. Chem. Ed , 2000, 38, 3011-3018.

 

47) "Synthesis of Optically Active Beta-Amino Acid N-Carboxyanhydrides". Cheng, J.; Ziller, J. W.; Deming, T. J. Org. Lett., 2000, 2, 1943-1946.

 

46) "Chain Initiation Efficiency in Cobalt- and Nickel-Mediated Polypeptide Synthesis". Deming, T. J. and Curtin, S. A. J. Am. Chem. Soc. , 2000, 122, 5710-5717.

 

45) "Structure of Complexes of Cationic Lipids and Poly(Glutamic Acid) Polypeptides: A Pinched Lamellar Phase". Subramanian, G.; Hjelm, R. P.; Deming, T. J.; Smith, G. S.; Li, Y.; Safinya, C. R. J. Am. Chem. Soc. , 2000, 122, 26-34.

 

44) "Biomimetic Synthesis of Ordered Silica Structures Mediated by Block Copolypeptides". Cha, J. N.; Stucky, G. D.; Morse, D. E. and Deming, T. J. Nature , 2000, 403, 289-292.

 

43) "Methylated Mono- and Diethyleneglycol Functionalized Polylysines: Nonionic, Helical, Water Soluble Polypeptides". Yu, M.; Nowak, A. P.; Pochan, D. P. and Deming, T. J. J. Am. Chem. Soc. , 1999, 121, 12210-12211.

 

42) "Initiators for End-Group Functionalized Polypeptides via Tandem Addition Reactions". Curtin, S. A. and Deming, T. J. J. Am. Chem. Soc. , 1999, 121, 7427-7428.

 

41) "Cobalt and Iron Initiators For the Controlled Polymerization of alpha-Amino Acid-N-Carboxyanhydrides". Deming, T. J. Macromolecules , 1999, 32, 4500-4502.

 

40) "Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of gamma-Benzyl Glutamate-N-Carboxyanhydride". Cheng, J.; Deming, T. J. Macromolecules (1999), 32, 4745-4747.

 

39) “Use of Transition Metal Catalysis to Prepare Functionalized and Block Copolypeptide Materials”. Deming, T. J., Curtin, S. A., Goodwin, A. A. Polym. Mat. Sci. Engr., 1999, 80, 37-38.

 

38) “Mechanistic Studies of Adhesion and Crosslinking in Synthetic Analogs of Marine Adhesive Proteins”. Yu, M., Deming, T. J. Polym. Mat. Sci. Engr., 1999, 80, 471-472.

 

37) “Enantioselective Polymerization of 5-Benzyl Glutamate N-Carboxyanhydride Using Chiral Nickel(0) Initiators”. Cheng, J., Deming, T. J. Polym. Mat. Sci. Engr., 1999, 80, 473-474.

 

36) "Mussel Byssus and Biomolecular Materials". Deming, T. J. Curr. Opn. Chem. Biol., 1999, 3, 100-105.

 

35) "Role of L-3,4-Dihydroxyphenylalanine in Mussel Adhesive Proteins". Yu, M.; Hwang, J.; Deming, T. J. J. Am. Chem. Soc. 1999, 121, 5825-5826.

 

34) "Reactions of alpha-Amino Acid-N-Carboxyanhydrides (NCAs) with Palladium(0) and Platinum(0): Role of Metallated NCAs in Polypeptide Synthesis". Goodwin, A. A.; Bu, X.; Deming, T. J. J. Organometallic Chem. 1999, 589, 111-114.

 

33) “Nickel Carbamate Initiators for Preparation of Functionalized Polypeptides”. Curtin, S. A., Deming, T. J. Polym. Prepr., 1998, 39(2), 242-243.

 

32) “Polypeptide Materials Using Nickel Initiators”. Deming, T. J., Curtin, S. A. Polym. Prepr., 1998, 39(2), 240-241.

 

31) "Synthetic Polypeptide Mimics of Marine Adhesives". Yu, M.; Deming, T. J. Macromolecules , 1998, 31, 4739-4745.

 

30) "Amino Acid Derived Nickelacycles: Intermediates in Nickel Mediated Polypeptide Synthesis". Deming, T. J. J. Am. Chem. Soc., 1998, 120, 4240-4241.

 

29) "Facile Synthesis of Block Copolypeptides of Defined Architecture". Deming, T. J. Nature, 1997, 390, 386-389.

 

28) "Synthetic Analogs of Marine Mussel Cement Proteins". Yu. M; DeSimone, T.; Deming, T. J. Polym. Prepr., 1997, 38, 101-102.

 

27) "Biosynthetic Incorporation and Chemical Modification of Alkene Functionality in Genetically Engineered Polymers". Deming, T. J.; Fournier, M. J.; Mason, T. L.; Tirrell, D. A. J. Macromol. Sci. A: Pure & Appl. Chem., 1997, A34(10), 2143-2150.

 

26) "Polypeptide Materials: New Synthetic Methods and Applications". Deming, T. J. Adv. Materials, 1997, 9, 299-311.

 

25) "Development of Transition Metal-Amine Initiators for Preparation of Well-Defined Poly(gamma-benzyl L-glutamate)". Deming, T. J. J. Am. Chem. Soc., 1997, 119, 2759-2760.

 

24) "Controlled Polymerization of alpha-Amino Acid-N-Carboxyanhydrides Using Transition Metal Initiators". Deming, T. J. Polym. Prepr., 1996, 37, 435-436.

 

23) "Structural Modification of a Periodic Polypeptide Through Biosynthetic Replacement of Proline with Azetidine-2-Carboxylic Acid". Deming, T. J.; Fournier, M. J.; Mason, T. L.; Tirrell, D. A. Macromolecules, 1996, 29, 1442-1444.

 

22) "Biocatalytic Synthesis of Polymers of Precisely Defined Structures". Deming, T. J.; Conticello, V. P.; Tirrell, D. A. in Nanotechnology, Timp, G. Ed., AIP Press, New York, (1999).

 

21) "Preparation of Active pi-Allylnickel-Based Polymerization Initiators". Novak, B. M. and Deming, T. J. U. S. Patent # 5,395,811 . Issued 3/7/1995.

 

20) "Living Polymerization of Butadiene at Both Chain Ends Via a Bimetallic Nickel Catalyst. Preparation of Hydroxytelechelic Poly(butadiene) and Symmetric Poly(Isocyanide-b-Butadiene-b-Isocyanide) Elastomeric Triblock Copolymers". Deming, T. J. and Novak, B. M. J. Am. Chem. Soc., 1994, 116, 2366.

 

19) "Living Bimetallic Initiators for the Preparation of Triblock Copolymers". Novak, B. M. and Deming, T. J. Macromol. Symp., 1994, 77, 405.

 

18) "Use of Copolymerization Phenomena in Mechanistic Studies: Monomer Substituent Effects in Nickel Catalyzed Isocyanide Polymerizations". Deming, T. J. and Novak, B. M. Macromolecules, 1993, 26, 7092.

 

17) "Preparation and Reactivity Studies of Highly Versatile, Nickel Based Polymerization Catalyst Systems". Deming, T. J. and Novak, B. M. Macromolecules, 1993, 26, 7089.

 

16) "Mechanistic Studies on the Nickel Catalyzed Polymerization of Isocyanides". Deming, T. J. and Novak, B. M. J. Am. Chem. Soc., 1993, 115, 9101.

 

15) "Linear Free Energy Relationships in The Nickel Catalyzed Polymerization of Isocyanides". Deming, T. J. and Novak, B. M., Polym. Prepr., 1993, 34, 885-6.

 

14) "Block Copolymers via Living Transition Metal Initiated Polymerizations: Change of Mechanism and Bimetallic Initiator Approaches". Deming, T. J. and Novak, B. M., Polym. Prepr., 1993, 34, 207-8.

 

13) "Enantioselective Polymerizations of Achiral Isocyanides. Preparation of Optically Active Helical Polymers Using Chiral Nickel Catalysts". Deming, T. J. and Novak, B. M. J. Am. Chem. Soc., 1992, 114, 7926.

 

12) "Living Polymerizations as Mechanistic Probes. Stereoselection in the Nickel Catalyzed Polymerization of Chiral Isocyanides". Deming, T. J. and Novak, B. M. J. Am. Chem. Soc., 1992, 114, 4400.

 

11) "Enantioselective Polymerizations of Achiral Isocyanides: Preparation of Optically Active Helical Polymers Using Chiral Nickel Catalysts", Deming, T.J. and Novak, B. M., Polym. Prepr., 1992, 33, 1231-2.

 

10) "Polyisocyanides using [(pi-C3H5)Ni(OC(O)CF3)]2: Rational Design and Implementation of a Living Polymerization Catalyst". Deming, T. J. and Novak, B. M. Macromolecules, 1991, 24, 6043.

 

9) "Change of Mechanism' Block Copolymerizations. The Formation of Block Copolymers Containing Helical and Amorphous Polyisocyanide and Elastomeric Polybutadiene Segments", Deming, T. J.; Novak, B. M. Polym. Mat. Sci. Engr., 1991, 65, 148.

 

8) "Stereoselection and Helicity in Living Polymerizations of Chiral Isocyanides", Deming, T. J. and Novak, B. M. Polym. Prepr., 1991, 32, 641-2.

 

7) "Change of Mechanism' Block Copolymerizations. The Formation of Block Copolymers Containing Helical Polyisocyanide and Elastomeric Polybutadiene Segments". Deming, T. J. and Novak, B. M. Macromolecules, 1991, 24, 5478.

 

6) "Optically Active Polyisocyanides Using [(pi-C3H5)Ni(OC(O)CF3)]2 Catalyst: The First Example of a Living Polymerization in The Presence of Air and Water", Deming, T. J. and Novak, B. M. Polym. Prepr., 1991, 32, 455-6.

 

5) "Organometallic Catalysis in Air and Water: Oxygen Enhanced, Nickel Catalyzed Polymerizations of Isocyanides". Deming, T. J. and Novak, B. M. Macromolecules, 1991, 24, 326.

 

4) "The Synthesis of Silyloxy Yttrium and Lanthanide Complexes From Anhydrous Nitrate and Oxo Alkoxide Precursors and the X-ray Crystal Structure of [Ce(OSiPh3)3(THF)3](THF)", Gradeff, P. S.; Yunlu, K.; Deming, T. J.; Olofson, J. M.; Doedens, R. J.; Evans, W. J. Inorg. Chem., 1990, 29, 420.

 

3) "Synthetic and Structural Studies of a Series of Soluble Cerium(IV) Alkoxide and Alkoxide Nitrate Complexes", Evans, W. J.; Deming, T. J.; Olofson, J. M.; Ziller, J. W. Inorg. Chem., 1989, 28, 4027.

 

2) "The Utility of Ceric Ammonium Nitrate Derived Alkoxide Complexes in the Synthesis of Organometallic Cerium(IV) Complexes: Synthesis and First X-ray Cyrstallographic Determination of a Tetravalent Cerium Cyclopentadienide Complex, (C5H5)3Ce(OCMe3)", Evans, W. J.; Deming, T. J.; Ziller, J. W. Organometallics, 1989, 8, 1581.

 

1) "Reactivity of Ceric Ammonium Nitrate With Sodium Cyclopentadienide. X-ray Crystal Structure of Ce(NO3)3(DME)2", Gradeff, P. S.; Yunlu, K.; Deming, T. J.; Olofson, J. M.; Ziller, J. W.; Evans, W. J. Inorg. Chem., 1989, 28, 2600.