Leveraging One- and Two-Electron Mechanisms in Nickel-Catalyzed Cross-Coupling Abstract: While palladium-catalyzed cross-coupling reactions have revolutionized the construction of multi-aryl scaffolds in pharmaceutical synthesis, the reactivity of nickel in mediating radical pathways has expanded the scope of cross-coupling to include various alkyl motifs. Through our mechanistic investigations and an understanding of ligand effects, we established that […]

Combinatorial Explosion: From Atom-Bond Arrangements to Exotic Diseases Abstract: Chemical synthesis and data science are two fields that operate in synergy. Molecules and the routes to synthesize them are easily represented as graphs while automated chemical synthesis strategies allow more and more synthesis data to be captured, for instance to feed machine learning algorithms. This […]