Abstract: N4-acetylcytidine is an ancient RNA modification catalyzed by an enzyme essential for human life. However, its distribution, dynamics, and function remain mysterious. In this seminar I will introduce my group’s work developing chemical tools to investigate RNA acetylation, why this led us to study an organism that thrives in solfatara (volcanic craters), and how […]
Brendan Mahoney, Ph.D. Clubb Group “Leveraging a new fluorescent fusion sensor reveals that bacterial chaperones associate with one another to rapidly transfer heme” ~and~ Sudeepa Rajan, Ph.D. Reisler Group “Disassembly of fascin bundled actin filaments via their oxidation by Mical”
“Growing Cells on Apples, LEGOs and Bread. Why Developing Unconventional Biomaterials Matters.”
Abstract: The NIH Molecular Libraries Program was founded to translate the discoveries of the Human Genome Project into therapeutics through a network of high-throughput screening (HTS) centers. A decade of discovery produced hundreds of probes—highly selective small molecules that modulate cellular function—but centralized HTS bears the same cost and infrastructure burdens of millennial DNA sequencing […]
“Enhanced Gas Transport in Hybrid Bio-Inorganic CO2 and N2 Fixation Systems” Abstract: With the surge of intermittent, renewable electricity, the storage of excessive electricity and reduction of CO2 or N2 into value-added chemicals is of great significance for a sustainable society. One viable route is to construct a hybrid inorganic-biological system that converts electricity into […]
“Van der Waals Integration beyond 2D Heterostructures” Abstract: The integration of dissimilar materials to form heterostructures with designable electronic interfaces is central in modern electronic devices and has thus been a long pursuit in material science. The traditional integration methods such as metal evaporation, atomic layer deposition (ALD) and epitaxial growth typically rely on strong […]
Abstract: Development of new synthetic strategies via organic photocatalysis in our group was described. Both photoacidic activity and photoredox activity of organic photocatalysts were discussed. A series of phenol-conjugated acridinium-based organic photoacids were rationally designed, synthesized and studied alongside commercially available phenolic catalyst, eosin Y. In the presence these photoacid catalysts and light, synthetic glycals […]
Sean D. Gallaher, Ph.D. Merchant Group "Prokaryotic-style polycistronic gene expression in eukaryotic green algae" ~and~ Einav Tayeb-Fligelman, Ph.D. Eisenberg Group "Modulation of Amyloid Formation of the Nucleoprotein of SARS-CoV-2"
“Nanomaterials Enable Delivery of Genetic Material Without TransgeneIntegration in Mature Plants”
Abstract: The introduction of unnatural functionality in biological systems coupled with detection using bioorthogonal chemical reactions revolutionized the field of chemical biology by enabling the investigation biological processes in live cells and simple organisms. However the translation to complex organisms has led to less than optimal results with high background noise due to cross reactivity […]
“Electron (De) Localization in f-Element Systems: From Fundamental Questions to QIS Design Principles” Abstract: The La Pierre group studies how collective magnetic, physical, and chemical properties arise from electron (de)localization phenomena in f-element systems. Our studies include the development of solid-state and solution methodologies for the synthesis of novel lanthanide and actinide (Th – Pu) […]
Secondary Coordination Effects in Artificial Biotin-Streptavidin Metalloenzymes Designing artificial metalloenzymes is of interest because they combine the catalytic activity of possibly non-physiological but highly catalytically potent metals and the selectivity and mild operational conditions enabled by the protein. This talk will focus on joint theory-experiment efforts to design Rh and Ir artificial metalloenzymes, catalyzing the […]
