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Strain molecules assist peptide and protein synthesis, a new venue for thiolactones

 Abstract: The broad application of macrocycles has illustrated significant potential as therapeutic agents. 12-membered ring cyclotetrapeptides are particularly attractive entities among all the cyclic peptides. Compared with macrocycles of larger ring size, the characteristic head-to-tail or end-to-end peptidyl backbone provides intrusive structural motif of circular peptides grants distinct biological properties such as resistance to degradation, […]

Chem 268: Hannah Bailey

Quinlan Group "Utilizing Drosophila melanogaster to understand the role of actin dynamics in oogenesis”

NSF Center for Integrated Catalysis Webinar Series

The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday, May 11th, 2021 at 1:00 PM. We are pleased to invite all students, postdocs, faculty, and staff.

Synthetic biology approaches to study and exploit RNA regulation

Abstract: RNA transcribed from the genome in the nucleus bears little resemblance to the RNA polymer it will ultimately become in the cytoplasm where it is translated into protein. Well-known processes such as capping, splicing and polyadenylation, as well as the recently discovered and ever-expanding list of diverse chemical modifications and editing, significantly alter the […]

OCDS Seminar: Prof. Rodney D. Priestley

“Molecular Dynamics and Glass Formation of Nanoscopically Confined Polymer” Many technological advances are driven by the ongoing emergence of nanostructured polymers as the critical component to enable innovation. Yet, from a materials design perspective, we cannot presume that the bulk properties of polymers define their behavior when physically confined to nanoscale dimensions. This is, in […]

Synthesis in a Boron World

Abstract: Nature has evolved highly sophisticated machinery for organic synthesis, many of which resemble molecular assembly-line processes. So far chemists have been able to apply this type of approach in the synthesis of peptides and oligonucleotides but in these reactions, simple amide (C‒N) or phosphate (P‒O) bonds are created. It is much more difficult to […]

CIC Careers in Green Chemistry Seminar Series

The Center for Integrated Catalysis is hosting a new seminar series called the "Careers in Green Chemistry." With these webinars, we aim to bring speakers from a wide variety of careers, linked through green chemistry, to come talk about their current job as well as the career path that led them to that position. We are pleased […]

Synthetic polypeptide-based materials for biological applications

Abstract: As more attention is focused on biomaterials for medical applications, synthetic polypeptides offer a useful approach towards designing novel biomimetic materials. Polypeptides are inherently biodegradable and biocompatible, and offer wide-ranging properties seen in living systems. The peptide backbone is enzymatically degradable while their side chain functionality can be modified to create an array of […]