Abstract: The NIH Molecular Libraries Program was founded to translate the discoveries of the Human Genome Project into therapeutics through a network of high-throughput screening (HTS) centers. A decade of discovery produced hundreds of probes—highly selective small molecules that modulate cellular function—but centralized HTS bears the same cost and infrastructure burdens of millennial DNA sequencing […]

“Van der Waals Integration beyond 2D Heterostructures” Abstract: The integration of dissimilar materials to form heterostructures with designable electronic interfaces is central in modern electronic devices and has thus been a long pursuit in material science. The traditional integration methods such as metal evaporation, atomic layer deposition (ALD) and epitaxial growth typically rely on strong […]

Abstract: The introduction of unnatural functionality in biological systems coupled with detection using bioorthogonal chemical reactions revolutionized the field of chemical biology by enabling the investigation biological processes in live cells and simple organisms. However the translation to complex organisms has led to less than optimal results with high background noise due to cross reactivity […]

Secondary Coordination Effects in Artificial Biotin-Streptavidin Metalloenzymes Designing artificial metalloenzymes is of interest because they combine the catalytic activity of possibly non-physiological but highly catalytically potent metals and the selectivity and mild operational conditions enabled by the protein. This talk will focus on joint theory-experiment efforts to design Rh and Ir artificial metalloenzymes, catalyzing the […]