Abstract: The process development of a BACE-1 inhibitor is described. In order to address major safety and scalability limitations in the Discovery synthesis, two novel reactions were developed. The discovery, development, and scale-up of these reactions will be described. Several additional methodologies which emerged during process research will also be presented.
Abstract:The selective introduction of functional groups at the positions of typically unreactive C-H bonds has been a longstanding challenge in catalysis. To this end, our group has developed practical methods for the catalytic functionalization of C-H bonds with main group reagents.(1-4) These studies have led us to a general strategy of installing a single transient […]
"Simulating linear and nonlinear optical spectra for chromophores in the condensed phase"
Panelist: Prof. Jennifer Casey Dept. of Chemistry and Biochemistry University of California, Los Angeles & Prof. Jay Foley Dept. of Chemistry William Paterson University & Prof. Jacob Olshansky Dept. of Chemistry Amherst College
Evan Maltz Wollman Group “Phenotypic Consequences of Gene Expression Variability”
“Imagining, Building, and Understanding the Next Generation Battery” Abstract: Electrochemical energy conversion and storage is critical for vehicle electrification and storing clean energy from intermittent sources (i.e. wind, solar) on the grid. Towards these goals, my group pursues the broad spectrum of stages necessary for technological innovation: (1) developing new tools to discover fundamental understandings, […]
Abstract:The potential to use mechanochemistry, either in isolated polymers or in polymeric materials, to trigger a programmed, desirable covalent molecular response was first revealed only a decade or so ago. Since that time, covalent polymer mechanochemistry has undergone a renaissance in which it has been extensively explored by a number of research groups and for a variety of purposes including (but not limited […]
Matthew Paul Agdanowski Yeates Group “The Development of an Imaging Scaffold for RNA Structural Analysis via Cryo-EM” and Janine Fu Loo Group “Targeting acyl-lysine modifications in the Rhodopseudomonas palustris proteome via diagnostic ions"
“Ambient Electrochemical Functionalization of Methane with d0 early transition metal-oxo species” Abstract: The abundant yet widely distributed methane (CH4) resources demands an efficient conversion of CH4 into liquid chemicals at ambient conditions with minimal infrastructure support. In the existing approaches of metal-catalyzed reactions and catalysis based on free-radical chain mechanism, the reactivities of the former metal species seem insufficient to […]
Abstract: Despite advances in high-throughput screening methods leading to a surge in the discovery of catalytic reactions, our knowledge of the molecular-level interactions in the rate- and selectivity-determining steps of catalytic reactions, especially those involving highly unstable and reactive open-shell intermediates, is rudimentary. These knowledge gaps prevent control, suppression or enhancement, of competing reaction channels that […]
