Title: Anaerobic Heteroatom Transfer Reactions Promoted by Photoexcited 1,3-Dipoles Abstract: Heteroatom units, such as carbonyls, alcohols, and amines, are prevalent motifs in many medicinally important compounds. Methods to incorporate these important functional groups at the expense of hydrocarbons rely on the use of non-commercial heteroatom transfer agents, precious transition metals, and/or costly engineered enzymes. Also, […]

Title: Development of Allosteric Inhibitors of VCP/ p97 to Interrogate Novel Biology and Fuel Cancer Drug Discovery Abstract: Clinical success in targeting the protein degradation pathway using proteasome inhibitors has spurred efforts to evaluate other aspects of this system as approaches to cancer therapy. Among those, the AAA ATPase, p97/ VCP, a master regulator of […]