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New Synthetic Opportunities through Organic Photocatalysis”

Abstract: Development of new synthetic strategies via organic photocatalysis in our group was described. Both photoacidic activity and photoredox activity of organic photocatalysts were discussed. A series of phenol-conjugated acridinium-based organic photoacids were rationally designed, synthesized and studied alongside commercially available phenolic catalyst, eosin Y. In the presence these photoacid catalysts and light, synthetic glycals […]

Chem 268: Sean D. Gallaher and Einav Tayeb-Fligelman

Sean D. Gallaher, Ph.D.     Merchant Group "Prokaryotic-style polycistronic gene expression in eukaryotic green algae" ~and~ Einav Tayeb-Fligelman, Ph.D.    Eisenberg Group "Modulation of Amyloid Formation of the Nucleoprotein of SARS-CoV-2"

Molecular recognition tools for chemistry in living systems

Abstract: The introduction of unnatural functionality in biological systems coupled with detection using bioorthogonal chemical reactions revolutionized the field of chemical biology by enabling the investigation biological processes in live cells and simple organisms. However the translation to complex organisms has led to less than optimal results with high background noise due to cross reactivity […]

Chem 278: Prof. Henry S. La Pierre

“Electron (De) Localization in f-Element Systems: From Fundamental Questions to QIS Design Principles” Abstract: The La Pierre group studies how collective magnetic, physical, and chemical properties arise from electron (de)localization phenomena in f-element systems. Our studies include the development of solid-state and solution methodologies for the synthesis of novel lanthanide and actinide (Th – Pu) […]

Chem 218 Student Exit Seminar: Jack Fuller

Secondary Coordination Effects in Artificial Biotin-Streptavidin Metalloenzymes Designing artificial metalloenzymes is of interest because they combine the catalytic activity of possibly non-physiological but highly catalytically potent metals and the selectivity and mild operational conditions enabled by the protein. This talk will focus on joint theory-experiment efforts to design Rh and Ir artificial metalloenzymes, catalyzing the […]

Strain molecules assist peptide and protein synthesis, a new venue for thiolactones

 Abstract: The broad application of macrocycles has illustrated significant potential as therapeutic agents. 12-membered ring cyclotetrapeptides are particularly attractive entities among all the cyclic peptides. Compared with macrocycles of larger ring size, the characteristic head-to-tail or end-to-end peptidyl backbone provides intrusive structural motif of circular peptides grants distinct biological properties such as resistance to degradation, […]

Chem 268: Hannah Bailey

Quinlan Group "Utilizing Drosophila melanogaster to understand the role of actin dynamics in oogenesis”

NSF Center for Integrated Catalysis Webinar Series

The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday, May 11th, 2021 at 1:00 PM. We are pleased to invite all students, postdocs, faculty, and staff.

Synthetic biology approaches to study and exploit RNA regulation

Abstract: RNA transcribed from the genome in the nucleus bears little resemblance to the RNA polymer it will ultimately become in the cytoplasm where it is translated into protein. Well-known processes such as capping, splicing and polyadenylation, as well as the recently discovered and ever-expanding list of diverse chemical modifications and editing, significantly alter the […]

OCDS Seminar: Prof. Rodney D. Priestley

“Molecular Dynamics and Glass Formation of Nanoscopically Confined Polymer” Many technological advances are driven by the ongoing emergence of nanostructured polymers as the critical component to enable innovation. Yet, from a materials design perspective, we cannot presume that the bulk properties of polymers define their behavior when physically confined to nanoscale dimensions. This is, in […]