Abstract: Novel technologies, preparative methods and synthetic strategies often represent a critical part of the investigation of new design ideas for bioactive compounds. Traditionally, natural products were considered to be the most challenging targets, but frequently medicinal chemistry structure-activity relationship (SAR) studies are also limited in practice by synthetic tractability. This presentation will select two […]
“Elucidating cellular pathways controlling protein aggregation, spread and toxicity in neurodegenerative disease”
"Aggregology: Science beyond Molecules"
Abstract: To genetically introduce new chemical reactivity into live systems, we engineered the genetic code to encode a new class of unnatural amino acids (Uaas), the latent bioreactive Uaas. These Uaas, after being incorporated into proteins, specifically react with target natural amino acid residues via proximity-enabled reactivity, enabling the selective formation of new covalent linkages […]
"Specificity in Protein-Protein Interactions: High-Throughput Characterization of Rationally Designed and Naturally Evolved Coiled-Coil Networks"
Controlled epitaxial growth and fabrication of hybrid halide perovskites Abstract: Organic–inorganic hybrid halide perovskites have demonstrated tremendous potential for next-generation electronic and optoelectronic devices due to their remarkable carrier dynamics. Current studies are mostly focused on polycrystals, since controlled growth of high-quality single crystals is challenging. In this presentation, I will discuss strategies that enabled […]
Controlling the Architecture of Nanoporous Materials to Regulate their Thermal Conductivity and Optical Transparency for Energy Efficient Windows Transparent, low thermal conductivity coatings can be applied to windows to increase the energy efficiency of buildings. Amorphous material such as silica make good thermal insulators due to their local atomic disorder that impedes heat conduction. Moreover, […]
Abstract: Natural products continue to inspire and serve as the basis of new medicines. They also provide intricate problems that expose limitations in the strategies and methods employed in chemical synthesis. Several strategies and methods that have been developed in our laboratory and applied to the syntheses of architecturally complex diterpenoid alkaloids, indole alkaloids, and […]
"Amyloid conformers in neurodegenerative disease"
"Combining cryogenic single-molecule fluorescence measurements and CryoEM: New methods with applications from biology to physical chemistry"
Developing Highly Efficient Electronic Structure Theory Methods for Large Scale Simulations Electronic structure simulations are now becoming an indispensable tool in chemistry research. The overall goal is to develop methods that give accurate results without sacrificing efficiency. In our group, we incorporate various computational techniques to drastically reduce the cost of simulations. This allows us […]
Electrifying Inorganic and Organic Synthesis Abstract: Electrochemical synthesis is a powerful tool for formulating functional materials and moleculesbecause it offers an additional level of control over the synthesis relative to its chemical counterpart by fine-tuning mass transfer, potential, or current. Electrochemical synthesis also allows the convenient analysis of chemical reaction thermodynamics and kinetics using the […]
