Liau Flyer Unraveling Chromatin Complexes with Small Molecules Abstract: The orchestrated interactions of chromatin complexes and transcription factors shape the cell’s epigenome to control gene expression and cell state. Dysregulation of these complexes and their interactions underlie human disease, and new therapeutic approaches to modulate them by blocking or even creating interactions are transforming paradigms […]

Yudin Flyer Synthetic Half-Reactions Abstract: This lecture will describe the concept of synthetic half-reactions and its applications towards understanding the interplay of chemical reactivity and conformational interconversions. Apart from electrochemistry, which offers half-reaction formalism to predict reactivity, there is no accepted system that dissects chemical transformations into simple components with the goal of matching uphill […]