Abstract: This lecture will describe recent developments in our efforts to develop catalysts for asymmetric reactions, in particular for the preparation of densely functionalized, stereochemically complex structures. Over time, our foci have been on enantioselectivity, site-selectivity and chemoselectivity. In much of our current work, we are studying issues of enantioselectivity as a prelude to the […]
“Characterization of RquA – a novel enzyme used in microbial rhodoquinone biosynthesis”
Abstract: Chemical reactivity can be utilized in many ways, including to improve synthetic access to new molecules and to devise tools to advance biomedicine. ‘Synthesis and catalysis’ are two themes interwoven throughout this presentation, which describes 1) the development of short synthetic routes to (–)-picrotoxinin, (–)-picrotin, and 5-methyl-picrotoxinin enabled by a late-stage strong-bond activation strategy for […]
"Multimetallic Nanomaterials by Design"
Abstract: Detailed understanding of catalytic transformations is key to designing better catalysts and overcome pertinent challenges in synthesis. This talk will give insights on case studies and reactivity designs recently undertaken in our laboratory. The focus will be on multinuclear metal catalysis for the chemoselective and modular construction of molecules, the exploration of organogermanes in […]
"Sortase-catalyzed surface assembly in monoderm bacteria"
Harnessing Bifunctional Ligands for Regioselective C–H Bond Functionalization
“Physics and the HIV-1 virus”
“High-accuracy Theoretical Treatment of Defects in Periodic Systems”
“2D Particle Surfactants and Pickering Emulsions for Reagent Compartmentalization”
"The development and targeting of epigenetic drugs for therapeutic benefit" Abstract: The talk will comprise two interconnected parts describing the development and targeting of epigenetic drugs for the treatment of disease. The development of bromodomain ligands for the treatment of disease: bromodomains, protein modules that ‘read’ of lysine acetylation state, have emerged as important therapeutic […]
“Releasing, or capturing, that is the question. Porous molecular materials” Porous materials are one important class where the shape and distribution of “empty” space throughout the framework is a main determinant for the resulting functionality. For instance, zeolites are available with many different pore size and geometries, which is the fundament of their wide spread […]
