Abstract: Perfluorocarbon nanoemulsions, droplets of fluorous solvent stabilized by a polymeric amphiphile dispersed in water, are an intriguing platform for drug delivery. The fluorous phase is biocompatible, has a high dissolved oxygen content, and is both lipophobic and hydrophobic, preventing the leaching of payloads. Here, we describe the use of perfluorocarbon nanoemulsions as a drug […]
The UCLA Molecular Biology Institute (MBI) will hold the 2020-2021 Sigman Symposium in honor of Professor David Sigman (1939-2001), who was an internationally renowned UCLA professor of chemistry and biological chemistry who illuminated the molecular mechanisms by which enzymes catalyze biological reactions and was one of the founding members of the MBI. 2020-2021 Sigman Award Honoree: […]
Abstract: This lecture will describe some recent developments in the area of electrophotocatalysis, with a particular focus on a trisaminocyclopropenium (TAC) ion catalyst developed by our group.
Quinlan Group "Biochemical Characterization of Mammalian Formin FHOD3 in Cardiomyocytes”
“Reservoir computing device composed by chemical dynamics”
Abstract: Biopharmaceutics are widely used to treat serious diseases, but the architectural and chemical complexity that makes proteins good therapeutics renders them susceptible to degradation and aggregation during manufacturing, transportation, and storage. Loss of intact biopharmaceutics causes patient under-dosing as well as adverse reactions. With the growth of biopharmaceuticals coming to market, the need increases […]
“Synthetic Nanorobot – from Individual Microswimmer to Active Swarm” Abstract: Over 60 years ago, Prof. Richard Feynman envisioned that, in principle, machines could be made so tiny, we can use them to construct matters from atomic/molecular scale; nanorobots can perform surgeries and deliver drugs at cellar level. Sixty years later, the scientific community finds an […]
“Superparamagnetic Core/Shell Mesoporous Silica Nanoparticle for Magnetic Heating-Induced Anticancer Drug Delivery” ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPION) generate heat in the presence of an alternating magnetic field (AMF) and are used in clinics to treat cancers. Mesoporous silica nanoparticles (SPION@MSN) embedded with SPION possess the advantageous features of both the SPION core and the shell, […]
Abstract: N4-acetylcytidine is an ancient RNA modification catalyzed by an enzyme essential for human life. However, its distribution, dynamics, and function remain mysterious. In this seminar I will introduce my group’s work developing chemical tools to investigate RNA acetylation, why this led us to study an organism that thrives in solfatara (volcanic craters), and how […]
Brendan Mahoney, Ph.D. Clubb Group “Leveraging a new fluorescent fusion sensor reveals that bacterial chaperones associate with one another to rapidly transfer heme” ~and~ Sudeepa Rajan, Ph.D. Reisler Group “Disassembly of fascin bundled actin filaments via their oxidation by Mical”
“Growing Cells on Apples, LEGOs and Bread. Why Developing Unconventional Biomaterials Matters.”
Abstract: The NIH Molecular Libraries Program was founded to translate the discoveries of the Human Genome Project into therapeutics through a network of high-throughput screening (HTS) centers. A decade of discovery produced hundreds of probes—highly selective small molecules that modulate cellular function—but centralized HTS bears the same cost and infrastructure burdens of millennial DNA sequencing […]
