Chem 228: Prof. Hirofumi Tanaka
“Reservoir computing device composed by chemical dynamics”
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Trehalose glycopolymer as an excipient for insulin stabilization: safety, mechanism, optimization, and fluid properties
Abstract: Biopharmaceutics are widely used to treat serious diseases, but the architectural and chemical complexity that makes proteins good therapeutics renders them susceptible to degradation and aggregation during manufacturing, transportation, and storage. Loss of intact biopharmaceutics causes patient under-dosing as well as adverse reactions. With the growth of biopharmaceuticals coming to market, the need increases […]
Chem 278: Prof. Jinyao Tang
“Synthetic Nanorobot – from Individual Microswimmer to Active Swarm” Abstract: Over 60 years ago, Prof. Richard Feynman envisioned that, in principle, machines could be made so tiny, we can use them to construct matters from atomic/molecular scale; nanorobots can perform surgeries and deliver drugs at cellar level. Sixty years later, the scientific community finds an […]
Chem 218 Student Exit Seminar: Fang-Chu Lin
“Superparamagnetic Core/Shell Mesoporous Silica Nanoparticle for Magnetic Heating-Induced Anticancer Drug Delivery” ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPION) generate heat in the presence of an alternating magnetic field (AMF) and are used in clinics to treat cancers. Mesoporous silica nanoparticles (SPION@MSN) embedded with SPION possess the advantageous features of both the SPION core and the shell, […]
Understanding the chemistry of volcanic RNA to treat cancer & COVID-19
Abstract: N4-acetylcytidine is an ancient RNA modification catalyzed by an enzyme essential for human life. However, its distribution, dynamics, and function remain mysterious. In this seminar I will introduce my group’s work developing chemical tools to investigate RNA acetylation, why this led us to study an organism that thrives in solfatara (volcanic craters), and how […]
Chem 268: Brendan Mahoney and Sudeepa Rajan
Brendan Mahoney, Ph.D. Clubb Group “Leveraging a new fluorescent fusion sensor reveals that bacterial chaperones associate with one another to rapidly transfer heme” ~and~ Sudeepa Rajan, Ph.D. Reisler Group “Disassembly of fascin bundled actin filaments via their oxidation by Mical”
Chem 228: Prof. Andrew Pelling
“Growing Cells on Apples, LEGOs and Bread. Why Developing Unconventional Biomaterials Matters.”
The Revolution Will Be Compartmentalized: Activity-Based and Cellular DNA-Encoded Library Technology
Abstract: The NIH Molecular Libraries Program was founded to translate the discoveries of the Human Genome Project into therapeutics through a network of high-throughput screening (HTS) centers. A decade of discovery produced hundreds of probes—highly selective small molecules that modulate cellular function—but centralized HTS bears the same cost and infrastructure burdens of millennial DNA sequencing […]
Chem 278 Prof. Liu Research Group Seminar
“Enhanced Gas Transport in Hybrid Bio-Inorganic CO2 and N2 Fixation Systems” Abstract: With the surge of intermittent, renewable electricity, the storage of excessive electricity and reduction of CO2 or N2 into value-added chemicals is of great significance for a sustainable society. One viable route is to construct a hybrid inorganic-biological system that converts electricity into […]
Chem 218 Student Exit Seminar: Peiqi Wang
“Van der Waals Integration beyond 2D Heterostructures” Abstract: The integration of dissimilar materials to form heterostructures with designable electronic interfaces is central in modern electronic devices and has thus been a long pursuit in material science. The traditional integration methods such as metal evaporation, atomic layer deposition (ALD) and epitaxial growth typically rely on strong […]
New Synthetic Opportunities through Organic Photocatalysis”
Abstract: Development of new synthetic strategies via organic photocatalysis in our group was described. Both photoacidic activity and photoredox activity of organic photocatalysts were discussed. A series of phenol-conjugated acridinium-based organic photoacids were rationally designed, synthesized and studied alongside commercially available phenolic catalyst, eosin Y. In the presence these photoacid catalysts and light, synthetic glycals […]
Chem 268: Sean D. Gallaher and Einav Tayeb-Fligelman
Sean D. Gallaher, Ph.D. Merchant Group "Prokaryotic-style polycistronic gene expression in eukaryotic green algae" ~and~ Einav Tayeb-Fligelman, Ph.D. Eisenberg Group "Modulation of Amyloid Formation of the Nucleoprotein of SARS-CoV-2"