Events Search and Views Navigation

Event Views Navigation

Today

Filters

Changing any of the form inputs will cause the list of events to refresh with the filtered results.

Chemical Strategies for Regulating DNA-Interactive Proteins: Targeting APOBEC Cytosine Deaminases and the N-Myc Transcription Factor

Abstract: Our laboratory focuses on the development of small molecule ligands and enzymatic inhibitors of proteins that interact with nucleic acids. We utilize biophysical and biochemical assays to screen chemical libraries to discover protein-binding ligands, which are then optimized using iterative rounds of molecular design, synthesis, and biological evaluation. Our overarching goals are to develop […]

Investigating Selectivity in Complex Systems: from Total Synthesis to Glycan Labeling

Abstract: The indole diterpenoids constitute a family of natural products that exhibit potent and selective Big Potassium (BK) ion channel inhibition. We have developed a unified synthetic strategy towards the indole diterpenoid class, culminating in the total synthesis of several representative congeners, including paspaline A and emindole PB. Density functional theory calculations are utilized to […]

Dr. Joonho Lee. Postdoctoral Fellow, Columbia University/Google Quantum AI Seminar

Challenging Problems in Quantum Chemistry: How to Diagnose Them and How to Tackle Them Quantum chemistry has become an indispensable tool in revealing the microscopic details of molecules and materials such as barrier heights, interaction energies, and correlation functions. The nature of electronic correlation is sometimes controversial, obscuring the optimal choice of quantum chemistry methods […]

Searching for Selective Catalytic Reactions in Complex Molecular Environments

Abstract: This lecture will describe recent developments in our efforts to develop catalysts for asymmetric reactions, in particular for the preparation of densely functionalized, stereochemically complex structures. Over time, our foci have been on enantioselectivity, site-selectivity and chemoselectivity. In much of our current work, we are studying issues of enantioselectivity as a prelude to the […]

Chemistry at the Biomedicine Interface: Synthesis and Catalysis

Abstract: Chemical reactivity can be utilized in many ways, including to improve synthetic access to new molecules and to devise tools to advance biomedicine. ‘Synthesis and catalysis’ are two themes interwoven throughout this presentation, which describes 1) the development of short synthetic routes to (–)-picrotoxinin, (–)-picrotin, and 5-methyl-picrotoxinin enabled by a late-stage strong-bond activation strategy for […]

Insight-Driven Strategies in Catalysis for Selective Functionalizations

Abstract: Detailed understanding of catalytic transformations is key to designing better catalysts and overcome pertinent challenges in synthesis. This talk will give insights on case studies and reactivity designs recently undertaken in our laboratory. The focus will be on multinuclear metal catalysis for the chemoselective and modular construction of molecules, the exploration of organogermanes in […]