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Stereoselective Gold Catalysis: From Metal-Ligand Cooperation to SN2 Glycosylation

Abstract: Metal-ligand cooperation is a versatile strategy for achieving efficient and/or stereoselective catalysis. Since 2014, we have developed a range of enabling remotely basic group-functionalized biaryl-2-ylphospine ligands (see Scheme A) for cooperative gold catalysis. With chiral elements built into these ligands, asymmetric transformations are developed in mechanistically rational manners. DFT calculations confirm the critical participation […]

Chem 228: Gerard C. L. Wong

“Molecular biomimicry by the SARS-CoV-2 virus: consequences for severe inflammation, coagulation, and dysregulation of antiviral responses”

CANCELLED! Chem 228: Steven Schwartz

“Rare Event Sampling, Protein Dynamics in enzymatic catalysis and directed evolution: lessons in artificial enzyme design”

Chem 228: Professor Wei Xiong, UCSD

Ultrafast Dynamics of Molecular Vibrational Polaritons For Chemistry and Quantum Simulation Molecular vibrational polaritons are hybrid half-light, half-matter quasiparticle. This hybrid quasiparticles not only inherit properties of both photons and matters, but also processes unique new photonic and molecular phenomena, including tilting chemical potential landscapes of reactions, adding new energy transfer pathways and strong photonic […]

Combining Synthetic Chemistry and Biology for Streamlining Access to Complex Molecules

Abstract: By virtue of their unrivaled selectivity profiles, enzymes possess remarkable potential to address unsolved challenges in chemical synthesis. The realization of this potential, however, has only recently gained traction. Recent advances in enzyme engineering and genome mining have provided a powerful platform for identifying and optimizing enzymatic transformations for synthetic applications and allowed us […]

NSF Center for Integrated Catalysis Webinar Series

The NSF Center for Integrated Catalysis is delighted to announce that it will be hosting a monthly webinar series. The next webinar of this series will be held on Tuesday, February 1st, 2022 at 10:30 AM. We are pleased to invite all students, postdocs, faculty, and staff.