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Writing the rules for targeting dynamic proteins

Abstract: Transcriptional coactivators and their partner transcription factors have been labeled as intrinsically disordered, fuzzy, and undruggable. We propose that the identification of conserved mechanisms of engagement between coactivators and their cognate activators should provide general principles for small-molecule modulator discovery. Towards that end, biophysical characterization of the structurally divergent coactivator Med25 reveals that it forms […]

Interfacial Chemistry of Colloidal Nanocrystals to Direct Energy Conversion: Prof. Brandi Cossairt, University of Washington

Interfacial Chemistry of Colloidal Nanocrystals to Direct Energy Conversion We are interested in developing colloidal nanocrystals for wide-ranging applications in energy interconversion. Our approach leverages the extraordinary properties of nanoscale systems and applies design principles of molecular inorganic chemistry. This talk will focus on two key research themes. First, we will explore how interfacial chemistry […]

Chem 228: Prof. Amber Krummel

"Exploiting Molecular Vibrations to Visualize Chemical Structures & Dynamics in Advanced Materials"

Chem 278: Dr. Evan Doud

“Beyond Traditional Superatom Ligands and Cores” Abstract: As technological development continues to advance at a rapid pace, there is an increasing need for next-generation materials. There are several fundamental challenges associated with developing these novel materials, including understanding the nature of the electronic contacts and tuning the specific properties of a material. In the context […]

Chem 218: First Principles Many-Body Theory and Quantum Dynamics for Materials Prediction – Prof. Yuan Ping, UCSC

First Principles Many-Body Theory and Quantum Dynamics for Materials Prediction  Materials prediction is the ultimate solution for ending blind experimental search within an expansive material parameter space. First-principles theory entirely based on quantum mechanics without prior input parameters is the perfect tool for new material design. In order to predict exotic quantum materials and out-of-equilibrium […]

Lessons from molecular evolution: from origin of life to phage-based nanomaterials

Abstract: Molecular evolution is a walk over a fitness landscape, in which populations explore sequence space through mutation and ‘climb’ up fitness peaks. The topography of the fitness landscape governs potential pathways for evolution and determines whether fitness can be optimized by natural selection. We are making exhaustive maps of fitness landscapes for catalytic RNA […]