Maynard, Heather D.


WebsiteHome URL
Division
Organic
Title
Faculty
Professor
Specialties
Organic
Materials
Nanoscience
Synthesis
Analytical

Contact Information

Email
Office
Molecular Sciences Building 4505B
(310) 267-5162
Lab
Molecular Sciences Building 4234
(310) 825-7385

Short Biography

Professor Maynard received her B.S. degree in Chemistry with Honors in 1992 at the University of North Carolina at Chapel Hill, her M.S. degree in Materials Science in 1995 at the University of California, Santa Barbara, and her Ph.D. in Chemistry in 2001 from the California Institute of Technology. After working as an American Chemical Society Postdoctoral Fellow at the Swiss Federal Institute of Technology (ETH) and University of Zurich, she joined the faculty at UCLA in 2002.

Biography

Prof. Heather D. Maynard received a Ph.D. from the California Institute of Technology for research in the group of Nobel Prize winner Robert Grubbs. She then moved to the laboratory of Jeffrey Hubbell at the Swiss Federal Institute of Technology (ETH) and University of Zurich, where from 2000-2002 she was an American Cancer Society Postdoctoral Fellow. Dr. Maynard joined the UCLA faculty as an Assistant Professor in August 2002 as the first Howard Reiss Career Development Chair in the Department of Chemistry and Biochemistry and as a member of the California Nanosystems Institute. Maynard is also a faculty affiliate in the Biomedical Engineering Interdepartmental Program, a member of the Center for Scalable and Integrated Nanomanufacturing, and a member of the Jonsson Comprehensive Cancer Center at UCLA. She is a faculty mentor in several training programs: the Chemistry-Biology Interface, the Materials Creation, the Nanotoxicology Research, and the Biotechnology Training Programs. For the latter she also serves as an executive committee member.

Maynard develops new strategies to synthesize protein-polymer conjugates and polymeric drugs. She also creates polymer films for patterning and arraying oriented and bioactive proteins. For her research at UCLA, she has received several awards including the Amgen New Faculty Award, NSF Career Award, the Alfred P. Sloan Fellowship, and the Seaborg Award. She was also selected as an Outstanding Emerging Investigator in Materials Chemistry by the RSC. Maynard has given over eighty invited lectures including the WCC ACS Lecture at Southern Methodist University and the Plenary Lecture at the 9th Annual UNESCO/IUPAC Conference on Macromolecules in South Africa. Maynard has also been selected to participate in symposia sponsored by the US National Academy of Sciences and US National Academy of Engineering.

Research Interest

The Maynard research group creates synthetic approaches to both solution and surface bound biohybrids and explores the application of these nanomaterials in medicine and biotechnology. There are three main research thrusts within the group.

  • (I) Well-defined protein and peptide polymer conjugates are prepared by living/controlled polymerizations. These conjugates are synthesized by polymerizing from proteins and amino acid-reactive initiators and applied as capture agents for proteomics and for wound healing.
  • (II) Homo and block copolymers with reactive side chains are synthesized by controlled radical polymerizations. Click chemistry is exploited to modify the polymers for drug delivery. Inhibition of anthrax toxin and cancer are two of the current targets of interest.
  • (III) Polymer films for conjugation of proteins to surfaces in specific orientation are prepared. Both micron and nano-sized patterns of proteins have been fabricated for use as biomaterial coatings.

Honors & Awards

  • Royal Society of Chemistry Fellow, 2011 
  • Alfred P. Sloan Research Fellow 
  • American Chemical Society Women's Committee Travel Award 
  • Amgen Amgen New Faculty Award 
  • Soroptimist Society Award 
  • Selected as an Outstanding Emerging Investigator in Materials Chemistry
  • NSF Career Award 
  • Seaborg Award 
  • Kavli Frontiers Fellow 
  • ACS, New Orleans Young Academic Investigators Symposium Lecturer 
  • University of Kansas Walter F. Enz Lecturer 
  • Hanson-Dow Award for Excellence in Teaching 
  • Selected as an Outstanding Emerging Investigator in Materials Chemistry 
  • Southern Methodist University WCC ACS Lecturer 
  • Howard Reiss Career Development Chair 
  • Materials Research Society 
  • Royal Chemical Society 
  • Society for Biomaterials 
  • The American Chemical Society

Publications

Publications:

Li RC, Broyer RM, Maynard HD   Well-Defined Polymers with Acetal Side Chains as Reactive Scaffolds Synthesized by Atom Transfer Radical Polymerization J. Polym. Sci, Part A; Polym. Chem., 2006; 44: 5004-5013.
Heredia KL, Maynard HD   Aminooxy-Functionalized Semitelechelic Polymers Synthesized by Atom Transfer Radical Polymerization, Polym. Prep., 2005; 46: 593-594.
Maynard HD, Hubbell JA   Discovery of a Sulfated Tetrapeptide that Binds to Vascular Endothelial Growth Factor Acta Biomaterialia, 2005; 1(4): 451-459.
Bontempo D, Maynard HD   Protein Macroinitiators for Atom Transfer Radical Polymerization, Polym. Prep., 2005; 46(1): 78-79.
Christman KL, Maynard HD   Protein Patterning on Polymer Films Using Localized Acid Generation, Polym. Prepr., 2005; 46(2): 1286.
Bontempo D, Li RC, Maynard HD   Synthesis of Biotinylated Polymers by Atom Transfer Radical Polymerization and Bioconjugate Formation, Polym. Prepr., 2005; 46(2): 435-436.
Bontempo D, Heredia KL, Fish BA, Maynard HD   Cysteine-reactive polymers synthesized by atom transfer radical polymerization for conjugation to proteins Journal of the American Chemical Society, 2004; 126(47): 15372-3.
Hwang J, Maynard HD   Multi-Functional Polymers Prepared by RAFT, Polym. Prepr., 2004; 45: 1083-1084.
Gunasekaran Karthikeyan, Nguyen Thi H, Maynard Heather D, Davis Thomas P, Bulmus Volga   Conjugation of siRNA with Comb-Type PEG Enhances Serum Stability and Gene Silencing Efficiency. Macromolecular rapid communications, 2011; 32(8): 654-9.
Christman Karen L, Broyer Rebecca M, Schopf Eric, Kolodziej Christopher M, Chen Yong, Maynard Heather D   Protein nanopatterns by oxime bond formation. Langmuir : the ACS journal of surfaces and colloids, 2011; 27(4): 1415-8.
Kolodziej, C. M.; Chang, C. \96W.; Maynard, H. D.   Glutathione S-Transferase as a General and Reversible Tag for Surface Immobilization of Proteins, J. Mater. Chem., 2011; 21: 1457-1461.
Alconcel, S. N. S.; Baas, A. S.; Maynard, H. D.   FDA-Approved Poly(ethylene glycol)-Protein Conjugates, Polymer Chemistry, 2011; 2: 1442-1448.
Broyer, R. M.; Scopf, E.; Kolodziej, C. M.; Chen, Y.; Maynard, H. D.   Dual Click Reactions to Micropattern Proteins, Soft Matter, ; DOI: 10.1039/C1SM05991B, published online.: .
Rock J. Mancini, Juneyoung Lee, and Heather D. Maynard   Trehalose Glycopolymers for Stabilization of Protein Conjugates to Environmental Stressors Journal of the American Chemical Society, 2012; 134(20): 8474-8479.