Harran, Patrick G.
D.J. and J.M. Cram Chair
Molecular Sciences Building 4505A
Molecular Sciences Building 5210
Professor Harran received his bachelors degree from Skidmore College in New York. He obtained a Ph.D. from Yale University in 1995 and completed an NIH sponsored postdoctoral fellowship at Stanford University in 1997. That fall, he joined the faculty at the University of Texas Southwestern Medical Center. In 2005, he was promoted to Full Professor and named the Mar Nell & F Andrew Bell Distinguished Chair in Biochemistry. He joined the faculty at UCLA in July 2008 as the inaugural D.J. & J.M. Cram Chair in Organic Chemistry.
Professor Harran was raised in the Adirondacks region of Upstate New York and trained in chemistry at Skidmore College. He spent three years working with Raymond Giguere on the use of sequenced bimolecular ene / intramolecular Diels-Alder reactions. He carried out doctoral studies with Frederick Ziegler at Yale University. There they explored behavior of photochemically-generated radical intermediates in the synthesis of optically active pyrroloindoles related to mitomycins. He then moved to Stanford University as an NIH sponsored postdoctoral fellow, working with Paul Wender to create simplified, functional analogs of bryostatin. In late 1997 Professor Harran accepted his first independent appointment in the Biochemistry Department at the University of Texas Southwestern Medical Center. He was promoted to Associate Professor with tenure in 2002 and Full Professor in 2005. During his time at Southwestern, the institution built a nationally recognized program in organic chemistry. The chemistry faculty at UTSW continues to grow and train students in a uniquely interdisciplinary environment. In the summer of 2008 Professor Harran accepted the inaugural D.J. & J.M. Cram Chair in Organic Chemistry at UCLA.
We study architectural aspects of building molecules. This is expressed through exercises in total synthesis, the development of reactions and processes, and in attempts to generally emulate small-molecule biosynthetic schemes. Like others in creative science, we hope to make the gap between 'what is' and 'what might be' smaller.
Rachel M. Greer, Michael Peyton, Jill E. Larsen, Luc Girard, Yang Xie, Adi Gazdar, Patrick Harran, Lai Wang, Rolf A. Brekken, Xiaodong Wang, and John D. Minna (2011) SMAC mimetic (JP1201) sensitizes non small cell lung cancers to multiple chemotherapy agents in an IAP dependent but TNFα independent manner. Cancer Research, 71, 7640-8. html
Kenneth V. Lawson, Tristan E. Rose, and Patrick G. Harran (2011) Synthesis of a Designed Sesquiterpenoid that Forms Useful Composites with Peptides and Related Oligomers. Tetrahedron Lett., 52, 653-654. html
Charles Caldwell, Gunnar Hanson, Susan Harran, Patrick G. Harran, Qi Wei, Ming Zhou (2010) Methods for Preparing Diazonamides. US Patent #7,851,620 B2, Issued Decemeber 14, 2010.
Patrick G. Harran, Xiaodong Wang, Jef K. De Brabander, Lin Li, Ranny Mathew Thomas, Hidetaka Suzuki (2010) Dimeric Small Molecule Potentiators of Apoptosis. US Patent #7,816,538 B2; Issued: October 19, 2010.