Use of High Throughput Experimentation and Computation in Development of New Reaction Methods

Seminar series
Organic Colloquium
When
Thu, Jan 15 5:00pm
Where
Cram Conference Room – 3440 Molecular Sciences Bldg
Speaker Professor Marisa C. Kozlowski
University of Pennsylvania
Department of Chemistry
Description

Organic Colloquium

“Use of High Throughput Experimentation and Computation in Development of New Reaction Methods”

Abstract.  Inspired by Nature's use of oxidative couplings to construct carbon-carbon, carbon-oxygen, and carbon-nitrogen bonds in many natural products, we have undertaken studies of these important transformations. The development of selective catalytic processes using high throughput experimentation for oxidative fragment couplings will be discussed.  Applications to the synthesis of chiral natural products and novel optically active materials will be presented.  In several cases, computation of reaction manifolds discovered using high throughput experimentation reveal mechanisms different than expected.

Attachments