Use of High Throughput Experimentation and Computation in Development of New Reaction Methods
| Seminar series | Organic Colloquium |
| When | Thu, Jan 15 5:00pm |
| Where | Cram Conference Room – 3440 Molecular Sciences Bldg |
| Speaker |
Professor Marisa C. Kozlowski University of Pennsylvania Department of Chemistry |
| Description | Organic Colloquium “Use of High Throughput Experimentation and Computation in Development of New Reaction Methods” Abstract. Inspired by Nature's use of oxidative couplings to construct carbon-carbon, carbon-oxygen, and carbon-nitrogen bonds in many natural products, we have undertaken studies of these important transformations. The development of selective catalytic processes using high throughput experimentation for oxidative fragment couplings will be discussed. Applications to the synthesis of chiral natural products and novel optically active materials will be presented. In several cases, computation of reaction manifolds discovered using high throughput experimentation reveal mechanisms different than expected. |
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