Ultra and High Sensitive NMR and MRI

Seminar series
Physical Chemistry Seminar
Mon, Mar 31 4:00pm
2033 Young Hall
Speaker Professor Xin Zhou
Wuhan Institute of Physics and Mathematics
Chinese Academy of Sciences

Abstract: Compared to other analytic or imaging techniques, such as fluorescence microscopy and computed tomography, the intrinsically low sensitivity of detection remains a challenge for the techniques of NMR (nuclear magnetic resonance) and MRI (magnetic resonance imaging). Sensitivity enhancement plays an important role in the advancement of NMR-based methods. We have developed instrumentation to hyperpolarize nuclear spins of noble gases (3He and 129Xe), resulting in very high NMR signal enhancement compared to thermal equilibrium, enabling ultrasensitive detection. Such hyperpolarized media are used for imaging the structure and function of the lung and brain. Even in low-field environments, NMR is possible with the use of laser-detection schemes based on a homebuilt atomic magnetometer operating near room temperature. In addition, we have demonstrated NMR detection of high-gyromagnetic-ratio nuclei other than protons in the context of multimodal and multifunctional molecular imaging of cancer cells.