Synthetic, medicinal, and translational chemistry of spliceosome modulators

Abstract: The spliceosome has been shown to be a promising target for the development of new anticancer therapeutics. Synthetic and chemical biological efforts directed toward the development of natural product-based splice modulators have shown that the potency of these compounds derives from their ability to selectively affect the alternate splicing of apoptotic genes in tumor cells. Here is discussed synthetic and bioactivity investigations of of polyketide natural products and their analogs and our progress in preclinical studies.