Synthetic, medicinal, and translational chemistry of spliceosome modulators

Seminar series
Organic Colloquium
When
Thu, Feb 20 4:00pm
Where
CS 76
Speaker Prof. Michael Burkart, Ph.D.
University of California, San Diego
Department of Chemistry and Biochemistry
Description

Abstract: The spliceosome has been shown to be a promising target for the development of new anticancer therapeutics. Synthetic and chemical biological efforts directed toward the development of natural product-based splice modulators have shown that the potency of these compounds derives from their ability to selectively affect the alternate splicing of apoptotic genes in tumor cells. Here is discussed synthetic and bioactivity investigations of of polyketide natural products and their analogs and our progress in preclinical studies.