Special Organic Colloquium: "Chemistry and Biology of Englerin A"

Seminar series
Organic Colloquium
Mon, May 19 3:00pm
Cram Conference Room – 3440 Molecular Sciences Bldg
Speaker Professor William J. Chain
University of Hawai’i at Manoa
Department of Chemistry

Special Organic Colloquium

"Chemistry and Biology of Englerin A"

Abstract.  Englerin A is a guaiane sesquiterpene that was isolated from the bark of Phyllanthus engleri, a plant indigenous to East Africa.  Englerin A is a potent and selective inhibitor of the growth of several human renal cancer cell lines (GI50 = 1–87 nM) through what appears to be a novel mechanism of action.  We have developed a brief and modular synthesis of englerin A that is amenable to the production of a diverse series of structural analogs and probe compounds that are not easily accessible via other synthetic efforts.  We have begun to characterize the mechanism of action of this exciting natural product, and support the development of englerin A as a new cancer therapeutic.  Our adventures in the organic synthesis of englerin A and our biological investigations will be described in detail.