Special Bio-Inorganic Chemistry Seminar

Seminar series
Tue, Jan 21 4:00pm
Young Hall 2033
Speaker Shiliang Tian
Stanford University
Department of Chemistry

Abstract: Multicopper oxidases (MCOs) are a large and diverse family of enzymes which couple the one-electron oxidation of various substrates with the four-electron reduction of dioxygen to water. Human serum ceruloplasmin (Cp) is the most complicated MCOs with one trinuclear copper (TNC) center and three type 1 copper (T1 Cu) sites. Cp is an essential ferroxidase critical for human iron homeostasis. Unraveling the mechanism of Cp is fundamentally important towards understanding the pathogenesis of metal-mediated diseases and metal neurotoxicity. In this seminar, I will present the understanding of the Cp reactivity based on kinetic and spectroscopic studies, mainly focusing on insights into the reaction intermediates, overall reaction mechanism and the role of the additional T1 Cu sites. I will also briefly discuss the implications on human iron homeostasis, oxidative stress and its possible role of causing neurodegenerative disease from the mechanistic perspective of Cp.