Small molecule inhibitors of 15-prostaglandin dehydrogenase promote tissue repair and regeneration

Seminar series
Organic Colloquium
When
Tue, Feb 9 4:00pm
Where
Zoom
Speaker Prof. Joseph Ready
UT Southwestern Medical Center
Department of Biochemistry
Description

Abstract: Prostaglandin E2 promotes tissue repair and regeneration in multiple tissues. Small molecule inhibitors of the PGE2-degrading enzyme, 15-prostaglandin dehydrogenase, could elevate PGE2 levels in vivo with applications in multiple disease contexts. We have discovered two chemical series of enzyme inhibitors. Medicinal chemistry efforts have led to sub-nM inhibitors with excellent bioavailability and physicochemical properties. Lead compounds demonstrate activity in mouse models of inflammatory bowel disease, recovery from bone marrow transplantation, and neurodegeneration.

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