Process Chemistry Perspective of an Investigational Small Molecule Drug

Seminar series
Organic Colloquium
Thu, Feb 7 5:00pm
Cram Conference Room - 3440 Mol Sci
Speaker Dr. Kumar Ranganathan
Senior Scientist, Chemical Process R&D
Amgen Inc.

Abstract.  Process chemistry perspective of an investigational small molecule drug will be discussed. Synthetic challenges faced upon scale-up, solutions to resolve, evolution of various generations of scalable processes with respect to ease of operation and cost of goods will be reviewed. Finally, development of asymmetric conjugate alkynylation of meldrum’s acid derived acceptors and the scope of reaction will be discussed.