Optical Microscopy beyond the Traditional Limits

Seminar series
Physical Chemistry Seminar
Mon, Oct 9 4:00pm
Young Hall 2033
Speaker Zhaowei Liu
UC San Diego
Electrical & Computer Engineering

Associate Professor
 Zhaowei Liu
 Dept of Electrical & Computer Engineering (ECE)
 Materials Science and Engineering Program (MSE)
 Center for Magnetic Recording Research (CMRR)

University of California, San Diego (UCSD)

Optical Microscopy beyond the Traditional LimitsSince Ernst Abbe described the diffraction limit over a century ago, high resolution optical imaging haslong been considered as the “holy grail” in optics. Many impressive methods to circumvent thediffraction limit have been developed, such as structured illumination microscopy (SIM), stochasticoptical reconstruction microscopy (STORM), stimulated emissddion depletion (STED), photoactivatedlocalization microscopy (PALM), and metamaterial based Hyperlens and far-field superlens (FSL). Allof these methods have tradeoffs between several factors such as resolution, speed, field of view, biocompatibility,photo toxicity, and experimental complexity. In this talk, I will review some of our workon super resolution microscopy, i.e. plasmonic structured illumination microscopy (PSIM) and localizedplasmonic structured illumination microscopy (LPSIM), which uniquely combine the super resolutionwith high imaging speed and achieve sub-50nm resolution and 50Hz frame rate simultaneously.Potential biological applications will also be discussed.
Capsule Bio:Zhaowei Liu is an Associate Professor in the Electrical and Computer Engineering Department atUCSD. He received his Ph.D. in Mechanical and Aerospace Engineering (MEMS/Nanotechnology)from UCLA in 2006, and was subsequently a postdoctoral researcher in NSF Nanoscale Science &Engineering Center (NSEC) and Mechanical Engineering at UC Berkeley. In 2008 he joined the facultyat UCSD. He is a recipient of the 2010 Society of Manufacturing Engineers (SME) Outstanding YoungManufacturing Engineer Award, the UCSD 2010 Hellman Faculty Fellowship Award, the 2013 Officeof Naval Research (ONR) Young Investigator Award, and the 2013 Defense Advanced ResearchProjects Agency (DARPA) Young Faculty Award. He is also the invited participant for the Frontiers ofScience 2010 by National Academy of Science and the Frontiers of Engineering 2014 by NationalAcademy of Engineering. He has been elevated to OSA Fellow in 2016. His previous work wasselected as top 100 science stories of 2007 by Discovery Magazine, and top 10 scientific discoveries of2008 by Time Magazine. His current research interest covers a broad spectrum of fields, including ofnanophotonics, super-resolution ultrafast imaging and sensing, bio-photonics, metamaterials,plasmonics, energy, LEDs, and micro/nanofabrication.