A Nanoparticle Enabled Focused Ultrasound-Stimulated Magnetic Resonance Imaging Spotlight: Tian Deng

Seminar series
Inorganic Chemistry
When
Wed, Oct 16 4:30pm to 5:30pm
Where
Molecular Sciences 3440
Speaker Tian Deng
UCLA
Chemistry & Biochemistry
Description

A Nanoparticle Enabled Focused Ultrasound-Stimulated Magnetic Resonance Imaging Spotlight

Magnetic resonance imaging (MRI) guided high-intensity focused ultrasound (HIFU) is used as a therapeutic technique in clinical practice. To improve its efficacy, it is essential to accurately identify, or spotlight target tissues for treatment. We present a novel contrast enhancement method based on MRI-guided HIFU and mesoporous silica nanoparticles (MSNs). Periodic HIFU modulation was applied to Gd-DTPA (gadolinium-diethylenetriamine pentaacetic acid) and poly(N-isopropylacrylamide) (PNIPAm) modified MSNs to generate reversible MRI T1 relaxivity changes, which caused periodic T1-weighted signal changes in regions of interest.  Fourier transform analysis was used to extract signal changes at the specific frequency of periodic HIFU modulation, and a modulation enhancement map (MEM) was reconstructed, which spotlights the region of interest with almost two orders of magnitude increase in contrast compared to conventional enhancement methods while inducing minimal heating.

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