Metal-Catalyzed Reactions of Non-traditional Electrophiles

Seminar series
Organic Colloquium
Thu, Jan 22 5:00pm
Cram Conference Room – 3440 Molecular Sciences Bldg
Speaker Professor Mary P. Watson
University of Delaware
Department of Chemistry and Biochemistry

Organic Colloquium

“Metal-Catalyzed Reactions of Non-traditional Electrophiles”

Abstract.  I will present our research on the development of transition-metal catalyzed reactions employing non-traditional electrophiles. We have developed enantioselective, copper-catalyzed alkynylations of oxocarbenium ion intermediates, which enable efficient access to highly enantioenriched oxygen heterocycles with alpha stereogenic centers. We have also identified reaction conditions for enantiospecific, nickel-catalyzed cross couplings of amine- and alcohol-derived alkyl electrophiles. The optimization and scope of these transformations will be discussed, along with our mechanistic and stereochemical hypotheses and supporting experiments.