Mechanisms for Drug Trapping and Releasing on Mesoporous Silica Nanoparticles Using Light

Seminar series
Inorganic Chemistry
Wed, May 29 4:30pm
Cram Conference Room, 3440 Mol Sci
Speaker Tania M. Guardado-Alvarez
Department of Chemistry and Biochemistry

Photoactivation of molecular stoppers over the pore openings of mesoporous silica nanoparticles releases intact cargo molecules from the pores.  The on-command release can be stimulated by either one UV photon or two coherent near-IR photons. Two-photon activation is particularly desirable for use in biological systems because it enables good tissue penetration and precise spatial control. These systems traps intact cargo molecules without the necessity of chemical modification and may have applications in photo-stimulated drug delivery.